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Effects of adolescent ethanol exposure on sleep in adult rats.
Alcohol. 2008 Dec; 42(8):631-9.A

Abstract

Although adolescent ethanol (EtOH) exposure has been associated with long-lasting changes in brain function, little is known as to whether EtOH exposure during adolescence alters sleep and cortical arousal. This study examined protracted alterations in sleep in adult rats exposed to EtOH during adolescence. Adolescent male Wistar rats were exposed to EtOH vapor for 12 h/day for 5 weeks. Cortical electroencephalograms were obtained during 4-h recording sessions after 5 weeks of withdrawal from EtOH. Adolescent EtOH exposure significantly reduced the mean duration of slow-wave sleep (SWS) episodes and the total amount of time spent in SWS in EtOH-exposed rats, compared to controls. Spectral analysis revealed that adolescent EtOH exposure significantly increased cortical peak frequencies during SWS in the 2-4, 4-6, and 6-8 Hz bands. Taken together, our findings suggest that chronic EtOH exposure in adolescent rats reduces measures of SWS, an effect also seen as part of normal aging. Although the cellular and molecular mechanisms mediating the consequences of EtOH exposure on the aging process are not known, the similarities between adolescent EtOH exposure and aging merits further investigation.

Authors+Show Affiliations

Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-1501, La Jolla, CA 92037, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18922666

Citation

Criado, José R., et al. "Effects of Adolescent Ethanol Exposure On Sleep in Adult Rats." Alcohol (Fayetteville, N.Y.), vol. 42, no. 8, 2008, pp. 631-9.
Criado JR, Wills DN, Walker BM, et al. Effects of adolescent ethanol exposure on sleep in adult rats. Alcohol. 2008;42(8):631-9.
Criado, J. R., Wills, D. N., Walker, B. M., & Ehlers, C. L. (2008). Effects of adolescent ethanol exposure on sleep in adult rats. Alcohol (Fayetteville, N.Y.), 42(8), 631-9. https://doi.org/10.1016/j.alcohol.2008.08.001
Criado JR, et al. Effects of Adolescent Ethanol Exposure On Sleep in Adult Rats. Alcohol. 2008;42(8):631-9. PubMed PMID: 18922666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of adolescent ethanol exposure on sleep in adult rats. AU - Criado,José R, AU - Wills,Derek N, AU - Walker,Brendan M, AU - Ehlers,Cindy L, Y1 - 2008/10/14/ PY - 2008/04/24/received PY - 2008/08/01/revised PY - 2008/08/11/accepted PY - 2008/10/17/pubmed PY - 2009/2/6/medline PY - 2008/10/17/entrez SP - 631 EP - 9 JF - Alcohol (Fayetteville, N.Y.) JO - Alcohol VL - 42 IS - 8 N2 - Although adolescent ethanol (EtOH) exposure has been associated with long-lasting changes in brain function, little is known as to whether EtOH exposure during adolescence alters sleep and cortical arousal. This study examined protracted alterations in sleep in adult rats exposed to EtOH during adolescence. Adolescent male Wistar rats were exposed to EtOH vapor for 12 h/day for 5 weeks. Cortical electroencephalograms were obtained during 4-h recording sessions after 5 weeks of withdrawal from EtOH. Adolescent EtOH exposure significantly reduced the mean duration of slow-wave sleep (SWS) episodes and the total amount of time spent in SWS in EtOH-exposed rats, compared to controls. Spectral analysis revealed that adolescent EtOH exposure significantly increased cortical peak frequencies during SWS in the 2-4, 4-6, and 6-8 Hz bands. Taken together, our findings suggest that chronic EtOH exposure in adolescent rats reduces measures of SWS, an effect also seen as part of normal aging. Although the cellular and molecular mechanisms mediating the consequences of EtOH exposure on the aging process are not known, the similarities between adolescent EtOH exposure and aging merits further investigation. SN - 1873-6823 UR - https://www.unboundmedicine.com/medline/citation/18922666/Effects_of_adolescent_ethanol_exposure_on_sleep_in_adult_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0741-8329(08)00281-4 DB - PRIME DP - Unbound Medicine ER -