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No relationship between mean plasma glucose and glycated haemoglobin in patients with cystic fibrosis-related diabetes.
Diabetes Metab. 2008 Dec; 34(6 Pt 1):568-73.DM

Abstract

AIM

Cystic fibrosis-related diabetes (CFRD) prevalence has increased dramatically with the improved life expectancy of patients with cystic fibrosis (CF). Glycated haemoglobin (HbA(1c)) is an important tool for monitoring blood glucose control but, unlike in type 1 and type 2 diabetes, a correlation between HbA(1c), fructosamine and mean plasma glucose has not been clearly established in CF. This study aimed to examine the relationship between mean plasma glucose and HbA(1c) or fructosamine in stable patients with CFRD.

METHODS

Fifteen type 1 diabetes and 13 CFRD patients (HbA(1c)<9.0%; no anaemia), matched for age and body mass index (BMI), provided 72 capillary blood glucose profiles taken 3days/month for three months. At the end of this time, HbA(1c) and fructosamine were measured. Mean plasma glucose was estimated using the Diabetes Control and Complications Trial (DCCT) conversion formula, and linear regressions carried out to establish its relationship with HbA(1c) and fructosamine.

RESULTS

In type 1 diabetes patients, mean plasma glucose correlated significantly with HbA(1c) (r=0.68; P=0.005). In CFRD patients, no correlation was found between mean plasma glucose and HbA(1c) (r=0.24; P=0.460). Also, no association was found between mean plasma glucose, representing the month before blood sampling, and fructosamine in either group.

CONCLUSION

Unlike in type 1 diabetes, HbA(1c) did not correlate with mean plasma glucose in CFRD subjects. Thus, having a normal HbA(1c) may not be sufficient to indicate a low risk of diabetes complications in CFRD. Further studies are required to explain such a discrepancy.

Authors+Show Affiliations

Endocrinology Division, Department of Medicine, centre hospitalier de l'université de Montréal, Montréal, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18922724

Citation

Godbout, A, et al. "No Relationship Between Mean Plasma Glucose and Glycated Haemoglobin in Patients With Cystic Fibrosis-related Diabetes." Diabetes & Metabolism, vol. 34, no. 6 Pt 1, 2008, pp. 568-73.
Godbout A, Hammana I, Potvin S, et al. No relationship between mean plasma glucose and glycated haemoglobin in patients with cystic fibrosis-related diabetes. Diabetes Metab. 2008;34(6 Pt 1):568-73.
Godbout, A., Hammana, I., Potvin, S., Mainville, D., Rakel, A., Berthiaume, Y., Chiasson, J. L., Coderre, L., & Rabasa-Lhoret, R. (2008). No relationship between mean plasma glucose and glycated haemoglobin in patients with cystic fibrosis-related diabetes. Diabetes & Metabolism, 34(6 Pt 1), 568-73. https://doi.org/10.1016/j.diabet.2008.05.010
Godbout A, et al. No Relationship Between Mean Plasma Glucose and Glycated Haemoglobin in Patients With Cystic Fibrosis-related Diabetes. Diabetes Metab. 2008;34(6 Pt 1):568-73. PubMed PMID: 18922724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No relationship between mean plasma glucose and glycated haemoglobin in patients with cystic fibrosis-related diabetes. AU - Godbout,A, AU - Hammana,I, AU - Potvin,S, AU - Mainville,D, AU - Rakel,A, AU - Berthiaume,Y, AU - Chiasson,J-L, AU - Coderre,L, AU - Rabasa-Lhoret,R, Y1 - 2008/10/14/ PY - 2007/12/03/received PY - 2008/05/12/revised PY - 2008/05/15/accepted PY - 2008/10/17/pubmed PY - 2009/2/27/medline PY - 2008/10/17/entrez SP - 568 EP - 73 JF - Diabetes & metabolism JO - Diabetes Metab VL - 34 IS - 6 Pt 1 N2 - AIM: Cystic fibrosis-related diabetes (CFRD) prevalence has increased dramatically with the improved life expectancy of patients with cystic fibrosis (CF). Glycated haemoglobin (HbA(1c)) is an important tool for monitoring blood glucose control but, unlike in type 1 and type 2 diabetes, a correlation between HbA(1c), fructosamine and mean plasma glucose has not been clearly established in CF. This study aimed to examine the relationship between mean plasma glucose and HbA(1c) or fructosamine in stable patients with CFRD. METHODS: Fifteen type 1 diabetes and 13 CFRD patients (HbA(1c)<9.0%; no anaemia), matched for age and body mass index (BMI), provided 72 capillary blood glucose profiles taken 3days/month for three months. At the end of this time, HbA(1c) and fructosamine were measured. Mean plasma glucose was estimated using the Diabetes Control and Complications Trial (DCCT) conversion formula, and linear regressions carried out to establish its relationship with HbA(1c) and fructosamine. RESULTS: In type 1 diabetes patients, mean plasma glucose correlated significantly with HbA(1c) (r=0.68; P=0.005). In CFRD patients, no correlation was found between mean plasma glucose and HbA(1c) (r=0.24; P=0.460). Also, no association was found between mean plasma glucose, representing the month before blood sampling, and fructosamine in either group. CONCLUSION: Unlike in type 1 diabetes, HbA(1c) did not correlate with mean plasma glucose in CFRD subjects. Thus, having a normal HbA(1c) may not be sufficient to indicate a low risk of diabetes complications in CFRD. Further studies are required to explain such a discrepancy. SN - 1262-3636 UR - https://www.unboundmedicine.com/medline/citation/18922724/No_relationship_between_mean_plasma_glucose_and_glycated_haemoglobin_in_patients_with_cystic_fibrosis_related_diabetes_ DB - PRIME DP - Unbound Medicine ER -