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Hemodynamic response of endotoxemic calves to treatment with small-volume hypertonic saline solution.
Am J Vet Res. 1991 Jul; 52(7):981-9.AJ

Abstract

The hemodynamic effects of hypertonic saline solution (HSS) resuscitation on endotoxic shock were examined in pentobarbital-anesthetized calves (8 to 20 days old). Escherichia coli (055:B5) endotoxin was infused IV at dosage of 0.1 microgram/kg of body weight for 30 minutes. Endotoxin induced large decreases in cardiac index, stroke volume, maximal rate of change of left ventricular pressure (+dP/dtmax), femoral and mesenteric arterial blood flow, glomerular filtration rate, urine production, and mean aortic pressure. Severe pulmonary arterial hypertension and increased pulmonary vascular resistance were evident at the end of endotoxin infusion. Treatment with HSS (2,400 mosm of NaCl/L, 4 ml/kg) or an equivalent sodium load of isotonic saline solution (ISS: 300 mosm of NaCl/L, 32 ml/kg) was administered 90 minutes after the end of endotoxin administration. Both solutions were infused IV over a 4- to 6-minute period. Administration of HSS induced immediate and significant (P less than 0.05) increase in stroke volume and central venous pressure, as well as significant decrease in pulmonary vascular resistance. These effects were sustained for 60 minutes, after which all variables returned toward preinfusion values. The hemodynamic response to HSS administration was suggestive of rapid plasma volume expansion and redistribution of cardiac output toward splanchnic circulation. Plasma volume expansion by HSS was minimal 60 minutes after resuscitation. Administration of ISS induced significant increase in cardiac index, stroke volume, femoral arterial blood flow, and urine production. These effects were sustained for 120 minutes, at which time, calves were euthanatized. Compared with HSS, ISS induced sustained increase in mean pulmonary arterial pressure and only a small increase in mesenteric arterial blood flow.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

1892278

Citation

Constable, P D., et al. "Hemodynamic Response of Endotoxemic Calves to Treatment With Small-volume Hypertonic Saline Solution." American Journal of Veterinary Research, vol. 52, no. 7, 1991, pp. 981-9.
Constable PD, Schmall LM, Muir WW, et al. Hemodynamic response of endotoxemic calves to treatment with small-volume hypertonic saline solution. Am J Vet Res. 1991;52(7):981-9.
Constable, P. D., Schmall, L. M., Muir, W. W., Hoffsis, G. F., & Shertel, E. R. (1991). Hemodynamic response of endotoxemic calves to treatment with small-volume hypertonic saline solution. American Journal of Veterinary Research, 52(7), 981-9.
Constable PD, et al. Hemodynamic Response of Endotoxemic Calves to Treatment With Small-volume Hypertonic Saline Solution. Am J Vet Res. 1991;52(7):981-9. PubMed PMID: 1892278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemodynamic response of endotoxemic calves to treatment with small-volume hypertonic saline solution. AU - Constable,P D, AU - Schmall,L M, AU - Muir,W W,3rd AU - Hoffsis,G F, AU - Shertel,E R, PY - 1991/7/1/pubmed PY - 1991/7/1/medline PY - 1991/7/1/entrez SP - 981 EP - 9 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 52 IS - 7 N2 - The hemodynamic effects of hypertonic saline solution (HSS) resuscitation on endotoxic shock were examined in pentobarbital-anesthetized calves (8 to 20 days old). Escherichia coli (055:B5) endotoxin was infused IV at dosage of 0.1 microgram/kg of body weight for 30 minutes. Endotoxin induced large decreases in cardiac index, stroke volume, maximal rate of change of left ventricular pressure (+dP/dtmax), femoral and mesenteric arterial blood flow, glomerular filtration rate, urine production, and mean aortic pressure. Severe pulmonary arterial hypertension and increased pulmonary vascular resistance were evident at the end of endotoxin infusion. Treatment with HSS (2,400 mosm of NaCl/L, 4 ml/kg) or an equivalent sodium load of isotonic saline solution (ISS: 300 mosm of NaCl/L, 32 ml/kg) was administered 90 minutes after the end of endotoxin administration. Both solutions were infused IV over a 4- to 6-minute period. Administration of HSS induced immediate and significant (P less than 0.05) increase in stroke volume and central venous pressure, as well as significant decrease in pulmonary vascular resistance. These effects were sustained for 60 minutes, after which all variables returned toward preinfusion values. The hemodynamic response to HSS administration was suggestive of rapid plasma volume expansion and redistribution of cardiac output toward splanchnic circulation. Plasma volume expansion by HSS was minimal 60 minutes after resuscitation. Administration of ISS induced significant increase in cardiac index, stroke volume, femoral arterial blood flow, and urine production. These effects were sustained for 120 minutes, at which time, calves were euthanatized. Compared with HSS, ISS induced sustained increase in mean pulmonary arterial pressure and only a small increase in mesenteric arterial blood flow.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/1892278/Hemodynamic_response_of_endotoxemic_calves_to_treatment_with_small_volume_hypertonic_saline_solution_ DB - PRIME DP - Unbound Medicine ER -