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C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis.
Genes Dev. 2008 Oct 15; 22(20):2831-42.GD

Abstract

Caenorhabditis elegans SIR-2.1, a member of the sirtuin family related to Saccharomyces cerevisiae Sir2p, has previously been implicated in aging. The mammalian homolog SIRT1 plays important roles in multiple cellular processes including transcriptional repression and stress response. We show that sir-2.1 is essential for the execution of apoptosis in response to DNA damage, and that sir-2.1 genetically acts in parallel to the worm p53-like gene cep-1. This novel cep-1-independent proapoptotic pathway does not require the daf-16 FOXO transcription factor. Cytological analysis of SIR-2.1 suggests a novel mechanism of apoptosis induction. During apoptosis SIR-2.1 changes its subcellular localization from the nucleus to the cytoplasm and transiently colocalizes with the C. elegans Apaf-1 homolog CED-4 at the nuclear periphery. SIR-2.1 translocation is an early event in germ cell apoptosis and is independent of apoptosis execution and cep-1, raising the possibility that SIR-2.1 translocation is linked to the induction of DNA damage-induced apoptosis.

Authors+Show Affiliations

Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18923081

Citation

Greiss, Sebastian, et al. "C. Elegans SIR-2.1 Translocation Is Linked to a Proapoptotic Pathway Parallel to Cep-1/p53 During DNA Damage-induced Apoptosis." Genes & Development, vol. 22, no. 20, 2008, pp. 2831-42.
Greiss S, Hall J, Ahmed S, et al. C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis. Genes Dev. 2008;22(20):2831-42.
Greiss, S., Hall, J., Ahmed, S., & Gartner, A. (2008). C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis. Genes & Development, 22(20), 2831-42. https://doi.org/10.1101/gad.482608
Greiss S, et al. C. Elegans SIR-2.1 Translocation Is Linked to a Proapoptotic Pathway Parallel to Cep-1/p53 During DNA Damage-induced Apoptosis. Genes Dev. 2008 Oct 15;22(20):2831-42. PubMed PMID: 18923081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis. AU - Greiss,Sebastian, AU - Hall,Julie, AU - Ahmed,Shawn, AU - Gartner,Anton, PY - 2008/10/17/pubmed PY - 2008/12/17/medline PY - 2008/10/17/entrez SP - 2831 EP - 42 JF - Genes & development JO - Genes Dev VL - 22 IS - 20 N2 - Caenorhabditis elegans SIR-2.1, a member of the sirtuin family related to Saccharomyces cerevisiae Sir2p, has previously been implicated in aging. The mammalian homolog SIRT1 plays important roles in multiple cellular processes including transcriptional repression and stress response. We show that sir-2.1 is essential for the execution of apoptosis in response to DNA damage, and that sir-2.1 genetically acts in parallel to the worm p53-like gene cep-1. This novel cep-1-independent proapoptotic pathway does not require the daf-16 FOXO transcription factor. Cytological analysis of SIR-2.1 suggests a novel mechanism of apoptosis induction. During apoptosis SIR-2.1 changes its subcellular localization from the nucleus to the cytoplasm and transiently colocalizes with the C. elegans Apaf-1 homolog CED-4 at the nuclear periphery. SIR-2.1 translocation is an early event in germ cell apoptosis and is independent of apoptosis execution and cep-1, raising the possibility that SIR-2.1 translocation is linked to the induction of DNA damage-induced apoptosis. SN - 0890-9369 UR - https://www.unboundmedicine.com/medline/citation/18923081/C__elegans_SIR_2_1_translocation_is_linked_to_a_proapoptotic_pathway_parallel_to_cep_1/p53_during_DNA_damage_induced_apoptosis_ L2 - http://www.genesdev.org/cgi/pmidlookup?view=long&pmid=18923081 DB - PRIME DP - Unbound Medicine ER -