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Detection of hereditary bisalbuminemia in a Greek family by capillary zone electrophoresis.
Hippokratia. 2008 Apr; 12(2):119-21.H

Abstract

It is presented herein a case of a family, four members of which suffer from hereditary bisalbuminemia. The abnormality was initially detected in a 29-year old male, by serum protein electrophoresis (SPE), during the investigation for possible multiple sclerosis. SPE also revealed the presence of a double albumin band in sera of the patient's sister, father and grandmother, almost confirming the inherited (genetic) form of bisalbuminemia. Possible causes related with the acquired form of bisalbuminemia were excluded for all examined individuals. SPE was performed by both automatic capillary zone electrophoresis and agaroze gel electrophoresis. All tested samples were immunofixated with special antisera, in order to exclude the presence of monoclonal fractions. Total albumin, total proteins and immunoglobulins varied in normal ranges. The relative mobility of the albumin variant was determined by a simple mixing experiment, which gave evidence of the fast-type form of inherited bisalbuminemia. This is the first report of hereditary bisalbuminemia in Greece.

Authors+Show Affiliations

Department of Immunology, Laboratory of Microbiology, AHEPA University Hospital, Thessaloniki, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports

Language

eng

PubMed ID

18923658

Citation

Angouridaki, C, et al. "Detection of Hereditary Bisalbuminemia in a Greek Family By Capillary Zone Electrophoresis." Hippokratia, vol. 12, no. 2, 2008, pp. 119-21.
Angouridaki C, Papageorgiou V, Tsavdaridou V, et al. Detection of hereditary bisalbuminemia in a Greek family by capillary zone electrophoresis. Hippokratia. 2008;12(2):119-21.
Angouridaki, C., Papageorgiou, V., Tsavdaridou, V., Giannousis, M., & Alexiou-Daniel, S. (2008). Detection of hereditary bisalbuminemia in a Greek family by capillary zone electrophoresis. Hippokratia, 12(2), 119-21.
Angouridaki C, et al. Detection of Hereditary Bisalbuminemia in a Greek Family By Capillary Zone Electrophoresis. Hippokratia. 2008;12(2):119-21. PubMed PMID: 18923658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of hereditary bisalbuminemia in a Greek family by capillary zone electrophoresis. AU - Angouridaki,C, AU - Papageorgiou,V, AU - Tsavdaridou,V, AU - Giannousis,M, AU - Alexiou-Daniel,S, PY - 2008/10/17/pubmed PY - 2008/10/17/medline PY - 2008/10/17/entrez KW - albumin KW - bisalbuminemia KW - protein electrophoresis SP - 119 EP - 21 JF - Hippokratia JO - Hippokratia VL - 12 IS - 2 N2 - It is presented herein a case of a family, four members of which suffer from hereditary bisalbuminemia. The abnormality was initially detected in a 29-year old male, by serum protein electrophoresis (SPE), during the investigation for possible multiple sclerosis. SPE also revealed the presence of a double albumin band in sera of the patient's sister, father and grandmother, almost confirming the inherited (genetic) form of bisalbuminemia. Possible causes related with the acquired form of bisalbuminemia were excluded for all examined individuals. SPE was performed by both automatic capillary zone electrophoresis and agaroze gel electrophoresis. All tested samples were immunofixated with special antisera, in order to exclude the presence of monoclonal fractions. Total albumin, total proteins and immunoglobulins varied in normal ranges. The relative mobility of the albumin variant was determined by a simple mixing experiment, which gave evidence of the fast-type form of inherited bisalbuminemia. This is the first report of hereditary bisalbuminemia in Greece. SN - 1790-8019 UR - https://www.unboundmedicine.com/medline/citation/18923658/Detection_of_hereditary_bisalbuminemia_in_a_Greek_family_by_capillary_zone_electrophoresis_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18923658/ DB - PRIME DP - Unbound Medicine ER -
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