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Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy.
Mol Nutr Food Res 2008; 52 Suppl 2:S230-40MN

Abstract

Allergy to kiwifruit appears to have become more common in Europe and elsewhere during the past several years. Seven allergens have been identified from kiwifruit so far, with actinidin, kiwellin and the thaumatin-like protein as the most relevant ones. In contrast to other fruits, no Bet v 1 homologues were characterized from kiwifruit so far. We cloned, purified, and characterized recombinant Bet v 1-homologous allergens from green (Actinidia deliciosa, Act d 8) and gold (Actinidia chinensis, Act c 8) kiwifruit, and confirmed the presence of its natural counterpart by inhibition assays. Well-characterized recombinant Act d 8 and Act c 8 were recognized by birch pollen/kiwifruit (confirmed by double-blind placebo-controlled food challenge) allergic patients in IgE immunoblots and ELISA experiments. The present data point out that Bet v 1 homologues are allergens in kiwifruit and of relevance for patients sensitized to tree pollen and kiwifruit, and might have been neglected so far due to low abundance in the conventional extracts used for diagnosis.

Authors+Show Affiliations

Biomay AG, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18925615

Citation

Oberhuber, Christina, et al. "Characterization of Bet V 1-related Allergens From Kiwifruit Relevant for Patients With Combined Kiwifruit and Birch Pollen Allergy." Molecular Nutrition & Food Research, vol. 52 Suppl 2, 2008, pp. S230-40.
Oberhuber C, Bulley SM, Ballmer-Weber BK, et al. Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy. Mol Nutr Food Res. 2008;52 Suppl 2:S230-40.
Oberhuber, C., Bulley, S. M., Ballmer-Weber, B. K., Bublin, M., Gaier, S., DeWitt, A. M., ... Hoffmann-Sommergruber, K. (2008). Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy. Molecular Nutrition & Food Research, 52 Suppl 2, pp. S230-40. doi:10.1002/mnfr.200800146.
Oberhuber C, et al. Characterization of Bet V 1-related Allergens From Kiwifruit Relevant for Patients With Combined Kiwifruit and Birch Pollen Allergy. Mol Nutr Food Res. 2008;52 Suppl 2:S230-40. PubMed PMID: 18925615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of Bet v 1-related allergens from kiwifruit relevant for patients with combined kiwifruit and birch pollen allergy. AU - Oberhuber,Christina, AU - Bulley,Sean M, AU - Ballmer-Weber,Barbara K, AU - Bublin,Merima, AU - Gaier,Sonja, AU - DeWitt,Asa Marknell, AU - Briza,Peter, AU - Hofstetter,Gerlinde, AU - Lidholm,Jonas, AU - Vieths,Stefan, AU - Hoffmann-Sommergruber,Karin, PY - 2008/10/18/pubmed PY - 2009/2/13/medline PY - 2008/10/18/entrez SP - S230 EP - 40 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 52 Suppl 2 N2 - Allergy to kiwifruit appears to have become more common in Europe and elsewhere during the past several years. Seven allergens have been identified from kiwifruit so far, with actinidin, kiwellin and the thaumatin-like protein as the most relevant ones. In contrast to other fruits, no Bet v 1 homologues were characterized from kiwifruit so far. We cloned, purified, and characterized recombinant Bet v 1-homologous allergens from green (Actinidia deliciosa, Act d 8) and gold (Actinidia chinensis, Act c 8) kiwifruit, and confirmed the presence of its natural counterpart by inhibition assays. Well-characterized recombinant Act d 8 and Act c 8 were recognized by birch pollen/kiwifruit (confirmed by double-blind placebo-controlled food challenge) allergic patients in IgE immunoblots and ELISA experiments. The present data point out that Bet v 1 homologues are allergens in kiwifruit and of relevance for patients sensitized to tree pollen and kiwifruit, and might have been neglected so far due to low abundance in the conventional extracts used for diagnosis. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/18925615/Characterization_of_Bet_v_1_related_allergens_from_kiwifruit_relevant_for_patients_with_combined_kiwifruit_and_birch_pollen_allergy_ L2 - https://doi.org/10.1002/mnfr.200800146 DB - PRIME DP - Unbound Medicine ER -