Tags

Type your tag names separated by a space and hit enter

Clinical pharmacology of cisatracurium during nitrous oxide-propofol anesthesia in children.
J Clin Anesth. 2008 Sep; 20(6):411-4.JC

Abstract

STUDY OBJECTIVE

To describe, in pediatric patients, the effects of three doses of cisatracurium during nitrous oxide-propofol anesthesia and to determine if larger doses result in faster onset time.

SETTING

College hospital.

SUBJECTS

75 ASA physical status I and II children, aged 15 to 60 months, undergoing surgery for hypospadias or undescendent testis.

INTERVENTIONS

Patients were randomly assigned to one of three groups according to the dose of cisatracurium: Group A = 0.1 mg/kg (two x effective dose), Group B = 0.15 mg/kg (three x effective dose), and Group C = 0.2 mg/kg (4 x effective dose).

MEASUREMENTS

Neuromuscular block was assessed with TOF-Guard (Biometer International, Odense, Denmark) accelerometry. Onset time (from cisatracurium injection to maximal depression of time to first twitch), duration of peak effect (time from cisatracurium injection to 5% recovery of time to first twitch), duration of clinical action (time from cisatracurium injection to 25% recovery of time to first twitch), and recovery index (recovery of time to first twitch from 25% to 75%) were recorded.

MAIN RESULTS

Cisatracurium had no effect on heart rate or blood pressure at any dose. Compared with Group A, onset times in Groups B and C were shorter; and durations of peak effect and clinical action in Groups B and C were longer (P < 0.01) than those in Group A. There was no difference in recovery index among the three groups. There was no difference in onset times between Groups B and C. Compared with Group B, durations of peak effect and clinical action in Group C were longer (P < 0.05 or P < 0.01).

CONCLUSION

Four times the effective dose of cisatracurium did not significantly shorten onset time beyond that produced with three times the effective dose in young children.

Authors+Show Affiliations

Department of Anesthesiology, West China Hospital, SiChuan University, ChengDu, China. sgwning@sina.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18929279

Citation

ShangGuan, WangNing, et al. "Clinical Pharmacology of Cisatracurium During Nitrous Oxide-propofol Anesthesia in Children." Journal of Clinical Anesthesia, vol. 20, no. 6, 2008, pp. 411-4.
ShangGuan W, Lian Q, Li J, et al. Clinical pharmacology of cisatracurium during nitrous oxide-propofol anesthesia in children. J Clin Anesth. 2008;20(6):411-4.
ShangGuan, W., Lian, Q., Li, J., & Gao, F. (2008). Clinical pharmacology of cisatracurium during nitrous oxide-propofol anesthesia in children. Journal of Clinical Anesthesia, 20(6), 411-4. https://doi.org/10.1016/j.jclinane.2008.03.011
ShangGuan W, et al. Clinical Pharmacology of Cisatracurium During Nitrous Oxide-propofol Anesthesia in Children. J Clin Anesth. 2008;20(6):411-4. PubMed PMID: 18929279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical pharmacology of cisatracurium during nitrous oxide-propofol anesthesia in children. AU - ShangGuan,WangNing, AU - Lian,QingQuan, AU - Li,Jun, AU - Gao,Fang, PY - 2007/05/20/received PY - 2008/03/10/revised PY - 2008/03/21/accepted PY - 2008/10/22/pubmed PY - 2009/1/27/medline PY - 2008/10/22/entrez SP - 411 EP - 4 JF - Journal of clinical anesthesia JO - J Clin Anesth VL - 20 IS - 6 N2 - STUDY OBJECTIVE: To describe, in pediatric patients, the effects of three doses of cisatracurium during nitrous oxide-propofol anesthesia and to determine if larger doses result in faster onset time. SETTING: College hospital. SUBJECTS: 75 ASA physical status I and II children, aged 15 to 60 months, undergoing surgery for hypospadias or undescendent testis. INTERVENTIONS: Patients were randomly assigned to one of three groups according to the dose of cisatracurium: Group A = 0.1 mg/kg (two x effective dose), Group B = 0.15 mg/kg (three x effective dose), and Group C = 0.2 mg/kg (4 x effective dose). MEASUREMENTS: Neuromuscular block was assessed with TOF-Guard (Biometer International, Odense, Denmark) accelerometry. Onset time (from cisatracurium injection to maximal depression of time to first twitch), duration of peak effect (time from cisatracurium injection to 5% recovery of time to first twitch), duration of clinical action (time from cisatracurium injection to 25% recovery of time to first twitch), and recovery index (recovery of time to first twitch from 25% to 75%) were recorded. MAIN RESULTS: Cisatracurium had no effect on heart rate or blood pressure at any dose. Compared with Group A, onset times in Groups B and C were shorter; and durations of peak effect and clinical action in Groups B and C were longer (P < 0.01) than those in Group A. There was no difference in recovery index among the three groups. There was no difference in onset times between Groups B and C. Compared with Group B, durations of peak effect and clinical action in Group C were longer (P < 0.05 or P < 0.01). CONCLUSION: Four times the effective dose of cisatracurium did not significantly shorten onset time beyond that produced with three times the effective dose in young children. SN - 0952-8180 UR - https://www.unboundmedicine.com/medline/citation/18929279/Clinical_pharmacology_of_cisatracurium_during_nitrous_oxide_propofol_anesthesia_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-8180(08)00185-2 DB - PRIME DP - Unbound Medicine ER -