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Study on novel hydrogels based on thermosensitive PNIPAAm with pH sensitive PDMAEMA grafts.

Abstract

A series of novel hydrogels based on poly(N-isopropylacrylamide) (PNIPAAm) with pendant poly(N-(2-(dimethylamino) ethyl)-methacrylamide) (PDMAEMA) grafts were designed and synthesized. The influence of the pendant PDMAEMA grafts on the properties of the resulted hydrogels was examined in terms of morphology observed by scanning electron microscopy (SEM), thermal property characterized by differential scanning calorimetry (DSC) and shrinking/swelling kinetics upon external temperature changes. In comparison with the conventional PNIPAAm hydrogels, resulting hydrogels presented favorable pH sensitivity as well as improved thermosensitive properties, including enlarged water containing capability at room temperature and faster shrinking/swelling rate upon heating. In addition, fish DNA, used as a model drug, was loaded into the hydrogels, and the controlled release behavior of the drug-loaded hydrogels at different temperatures (22 and 37 degrees C) was further studied.

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  • Authors+Show Affiliations

    ,

    Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China.

    , , , , ,

    Source

    Colloids and surfaces. B, Biointerfaces 67:2 2008 Dec 01 pg 245-52

    MeSH

    Acrylic Resins
    Calorimetry, Differential Scanning
    Hydrogels
    Hydrogen-Ion Concentration
    Kinetics
    Methacrylates
    Microscopy, Electron, Scanning
    Nylons
    Temperature

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18929467