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Antioxidant activity of L-adrenaline: a structure-activity insight.
Chem Biol Interact. 2009 May 15; 179(2-3):71-80.CB

Abstract

L-adrenaline belongs to a group of the compounds known as catecholamines, which play an important role in the regulation of physiological process in living organisms. The antioxidant activity and antioxidant mechanism of L-adrenaline was clarified using various in vitro antioxidant assays including 1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), N,N-dimethyl-p-phenylenediamine (DMPD(+)), and superoxide anion radicals (O(2)(-)) scavenging activity, hydrogen peroxide (H(2)O(2)), total antioxidant activity, ferric ions (Fe(3+)) and cupric ions (Cu(2+)) reducing ability, ferrous ions (Fe(2+)) chelating activity. L-adrenaline inhibited 74.2% lipid peroxidation of a linoleic acid emulsion at 30 microg/mL concentration. On the other hand, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol and trolox displayed 83.3, 82.1, 68.1 and 81.3% inhibition on the peroxidation of linoleic acid emulsion at the same concentration, respectively. BHA, BHT, alpha-tocopherol and trolox were used as reference antioxidants and radical scavenger compounds. Moreover, this study will bring an innovation for further studies related to antioxidant properties of L-adrenaline. According to present study, L-adrenaline had effective in vitro antioxidant and radical scavenging activity.

Authors+Show Affiliations

Atatürk University, Faculty of Sciences, Department of Chemistry, TR-25240-Erzurum, Turkey. igulcin@atauni.edu.tr

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18929549

Citation

Gülçin, Ilhami. "Antioxidant Activity of L-adrenaline: a Structure-activity Insight." Chemico-biological Interactions, vol. 179, no. 2-3, 2009, pp. 71-80.
Gülçin I. Antioxidant activity of L-adrenaline: a structure-activity insight. Chem Biol Interact. 2009;179(2-3):71-80.
Gülçin, I. (2009). Antioxidant activity of L-adrenaline: a structure-activity insight. Chemico-biological Interactions, 179(2-3), 71-80. https://doi.org/10.1016/j.cbi.2008.09.023
Gülçin I. Antioxidant Activity of L-adrenaline: a Structure-activity Insight. Chem Biol Interact. 2009 May 15;179(2-3):71-80. PubMed PMID: 18929549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity of L-adrenaline: a structure-activity insight. A1 - Gülçin,Ilhami, Y1 - 2008/09/26/ PY - 2008/08/24/received PY - 2008/09/16/revised PY - 2008/09/17/accepted PY - 2008/10/22/pubmed PY - 2009/5/7/medline PY - 2008/10/22/entrez SP - 71 EP - 80 JF - Chemico-biological interactions JO - Chem. Biol. Interact. VL - 179 IS - 2-3 N2 - L-adrenaline belongs to a group of the compounds known as catecholamines, which play an important role in the regulation of physiological process in living organisms. The antioxidant activity and antioxidant mechanism of L-adrenaline was clarified using various in vitro antioxidant assays including 1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), N,N-dimethyl-p-phenylenediamine (DMPD(+)), and superoxide anion radicals (O(2)(-)) scavenging activity, hydrogen peroxide (H(2)O(2)), total antioxidant activity, ferric ions (Fe(3+)) and cupric ions (Cu(2+)) reducing ability, ferrous ions (Fe(2+)) chelating activity. L-adrenaline inhibited 74.2% lipid peroxidation of a linoleic acid emulsion at 30 microg/mL concentration. On the other hand, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol and trolox displayed 83.3, 82.1, 68.1 and 81.3% inhibition on the peroxidation of linoleic acid emulsion at the same concentration, respectively. BHA, BHT, alpha-tocopherol and trolox were used as reference antioxidants and radical scavenger compounds. Moreover, this study will bring an innovation for further studies related to antioxidant properties of L-adrenaline. According to present study, L-adrenaline had effective in vitro antioxidant and radical scavenging activity. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/18929549/Antioxidant_activity_of_L_adrenaline:_a_structure_activity_insight_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(08)00500-0 DB - PRIME DP - Unbound Medicine ER -