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The effect of exercise and estrogen on osteoprotegerin in premenopausal women.
Bone. 2009 Jan; 44(1):137-44.BONE

Abstract

BACKGROUND

The benefits of exercise are widely recognized, however physically active women can develop exercise associated menstrual cycle disturbances such as amenorrhea (i.e., estrogen deficiency) secondary to a chronic energy deficiency.

OBJECTIVE

To assess the effects of exercise status and estrogen deficiency on osteoprotegerin (OPG) and its relationship to bone resorption in premenopausal exercising women.

DESIGN

Cross-sectional study of serum OPG, urinary c-telopeptides (uCTX), urinary estrone 3-glucuronide (E1G), urinary pregnanediol 3-glucuronide (PdG) and bone mineral density (BMD) measured on multiple occasions in 67 women. Volunteers were retrospectively grouped: 1) sedentary menstruating group (SedMen n=8), 2) exercising menstruating group (ExMen, n=36), and 3) exercising amenorrheic group (ExAmen, n=23). One-way ANOVAs were performed, and LSD post-hoc tests were performed when differences were detected.

RESULTS

Subjects were similar with respect to age (24.2+/-1.0 years), weight (57.8+/-1.7 kg), and height (164.3+/-1.3 cm) (p>0.05). ExMen and ExAmen groups were more aerobically fit (p=0.003) and had less body fat (p=0.002) than the SedMen group. Resting energy expenditure/fat free mass was lowest (p=0.001) in the ExAmen groups. Mean E1G across the measurement period (p<0.001) and overall E1G exposure as assessed by E1G area under the curve (AUC) (p<0.001) were lower in the ExAmen group vs. the SedMen and ExMen groups. U-CTX-I was elevated (p=0.033) in the ExAmen group (281.8+/-40.3 microg/L/mmCr), compared with the SedMen and ExMen groups (184.5+/-22.4, 197.2+/-14.7 microg/L/mmCr, respectively). OPG was suppressed (p=0.005) in the ExAmen group (4.6+/-0.2 pmol/L) vs. ExMen group (5.2+/-0.2 pmol/L), and OPG was lower in the SedMen group (4.1+/-0.3 pmol/L) compared with the ExMen group. Findings were translated to BMD; the ExAmen group had suppressed total body BMD (p=0.014) and L2-L4 BMD (p=0.015) vs. the ExMen group.

CONCLUSIONS

Our results suggest that OPG responds to the bone loading effect of exercise, and that suppressed OPG may play a role in the etiology of increased bone resorption observed in exercising women with chronic estrogen deficiency secondary to hypothalamic amenorrhea.

Authors+Show Affiliations

Department of Exercise Science, University of Toronto, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18929691

Citation

West, Sarah L., et al. "The Effect of Exercise and Estrogen On Osteoprotegerin in Premenopausal Women." Bone, vol. 44, no. 1, 2009, pp. 137-44.
West SL, Scheid JL, De Souza MJ. The effect of exercise and estrogen on osteoprotegerin in premenopausal women. Bone. 2009;44(1):137-44.
West, S. L., Scheid, J. L., & De Souza, M. J. (2009). The effect of exercise and estrogen on osteoprotegerin in premenopausal women. Bone, 44(1), 137-44. https://doi.org/10.1016/j.bone.2008.09.008
West SL, Scheid JL, De Souza MJ. The Effect of Exercise and Estrogen On Osteoprotegerin in Premenopausal Women. Bone. 2009;44(1):137-44. PubMed PMID: 18929691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of exercise and estrogen on osteoprotegerin in premenopausal women. AU - West,Sarah L, AU - Scheid,Jennifer L, AU - De Souza,Mary Jane, Y1 - 2008/09/26/ PY - 2008/04/27/received PY - 2008/08/14/revised PY - 2008/09/08/accepted PY - 2008/10/22/pubmed PY - 2009/1/29/medline PY - 2008/10/22/entrez SP - 137 EP - 44 JF - Bone JO - Bone VL - 44 IS - 1 N2 - BACKGROUND: The benefits of exercise are widely recognized, however physically active women can develop exercise associated menstrual cycle disturbances such as amenorrhea (i.e., estrogen deficiency) secondary to a chronic energy deficiency. OBJECTIVE: To assess the effects of exercise status and estrogen deficiency on osteoprotegerin (OPG) and its relationship to bone resorption in premenopausal exercising women. DESIGN: Cross-sectional study of serum OPG, urinary c-telopeptides (uCTX), urinary estrone 3-glucuronide (E1G), urinary pregnanediol 3-glucuronide (PdG) and bone mineral density (BMD) measured on multiple occasions in 67 women. Volunteers were retrospectively grouped: 1) sedentary menstruating group (SedMen n=8), 2) exercising menstruating group (ExMen, n=36), and 3) exercising amenorrheic group (ExAmen, n=23). One-way ANOVAs were performed, and LSD post-hoc tests were performed when differences were detected. RESULTS: Subjects were similar with respect to age (24.2+/-1.0 years), weight (57.8+/-1.7 kg), and height (164.3+/-1.3 cm) (p>0.05). ExMen and ExAmen groups were more aerobically fit (p=0.003) and had less body fat (p=0.002) than the SedMen group. Resting energy expenditure/fat free mass was lowest (p=0.001) in the ExAmen groups. Mean E1G across the measurement period (p<0.001) and overall E1G exposure as assessed by E1G area under the curve (AUC) (p<0.001) were lower in the ExAmen group vs. the SedMen and ExMen groups. U-CTX-I was elevated (p=0.033) in the ExAmen group (281.8+/-40.3 microg/L/mmCr), compared with the SedMen and ExMen groups (184.5+/-22.4, 197.2+/-14.7 microg/L/mmCr, respectively). OPG was suppressed (p=0.005) in the ExAmen group (4.6+/-0.2 pmol/L) vs. ExMen group (5.2+/-0.2 pmol/L), and OPG was lower in the SedMen group (4.1+/-0.3 pmol/L) compared with the ExMen group. Findings were translated to BMD; the ExAmen group had suppressed total body BMD (p=0.014) and L2-L4 BMD (p=0.015) vs. the ExMen group. CONCLUSIONS: Our results suggest that OPG responds to the bone loading effect of exercise, and that suppressed OPG may play a role in the etiology of increased bone resorption observed in exercising women with chronic estrogen deficiency secondary to hypothalamic amenorrhea. SN - 1873-2763 UR - https://www.unboundmedicine.com/medline/citation/18929691/The_effect_of_exercise_and_estrogen_on_osteoprotegerin_in_premenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(08)00774-6 DB - PRIME DP - Unbound Medicine ER -