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Impact of body mass index and waist-to-hip ratio on clinical outcomes in patients with ST-segment elevation acute myocardial infarction (from the Korean Acute Myocardial Infarction Registry).
Am J Cardiol 2008; 102(8):957-65AJ

Abstract

The relation between body mass index (BMI) and waist-to-hip ratio (WHR) to clinical outcomes in patients with ST-segment elevation acute myocardial infarction (MI) has not been well described. As part of the Korean Acute MI Registry, we enrolled 3,734 eligible patients who were diagnosed with ST-segment elevation acute MI. The study population was categorized by BMI (into 4 groups according to the World Health Organization classification for the Asian population) and WHR (into 2 sets of 4 groups, 1 set for men and another for women, based on the INTERHEART study). Baseline characteristics and clinical outcomes were analyzed and compared among the BMI and WHR categories. Mean follow-up duration was 199 +/- 37 days. In the BMI category, underweight versus obese patients were older, were more likely to present with heart failure, and underwent guideline-based treatments less frequently. In the WHR category, the reverse trends were apparent for the latter factors except treatment-use frequencies. The highest mortality rate was observed in patients with the lowest BMI and the highest WHR. In an adjusted model, the highest WHR (hazard ratio 5.57, 95% confidence interval 1.53 to 12.29, p = 0.009) and the underweight (hazard ratio 2.88, 95% confidence interval 1.17 to 6.08, p = 0.021) categories within the 2 anthropometric indexes remained as mortality risk factors. In conclusion, the relation between obesity and prognosis after ST-segment elevation acute MI appears complex and should be further assessed in larger population-based cohort studies to determine the associations apparent in this study.

Authors+Show Affiliations

Yeungnam University Hospital, Daegu, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18929693

Citation

Lee, Sang-Hee, et al. "Impact of Body Mass Index and Waist-to-hip Ratio On Clinical Outcomes in Patients With ST-segment Elevation Acute Myocardial Infarction (from the Korean Acute Myocardial Infarction Registry)." The American Journal of Cardiology, vol. 102, no. 8, 2008, pp. 957-65.
Lee SH, Park JS, Kim W, et al. Impact of body mass index and waist-to-hip ratio on clinical outcomes in patients with ST-segment elevation acute myocardial infarction (from the Korean Acute Myocardial Infarction Registry). Am J Cardiol. 2008;102(8):957-65.
Lee, S. H., Park, J. S., Kim, W., Shin, D. G., Kim, Y. J., Kim, D. S., ... Jeong, M. H. (2008). Impact of body mass index and waist-to-hip ratio on clinical outcomes in patients with ST-segment elevation acute myocardial infarction (from the Korean Acute Myocardial Infarction Registry). The American Journal of Cardiology, 102(8), pp. 957-65. doi:10.1016/j.amjcard.2008.06.022.
Lee SH, et al. Impact of Body Mass Index and Waist-to-hip Ratio On Clinical Outcomes in Patients With ST-segment Elevation Acute Myocardial Infarction (from the Korean Acute Myocardial Infarction Registry). Am J Cardiol. 2008 Oct 15;102(8):957-65. PubMed PMID: 18929693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of body mass index and waist-to-hip ratio on clinical outcomes in patients with ST-segment elevation acute myocardial infarction (from the Korean Acute Myocardial Infarction Registry). AU - Lee,Sang-Hee, AU - Park,Jong-Seon, AU - Kim,Woong, AU - Shin,Dong-Gu, AU - Kim,Young-Jo, AU - Kim,Dong-Su, AU - Choi,Dong-Ju, AU - Han,Kyoo-Rok, AU - Kim,Chong-Jin, AU - Cho,Myeong-Chan, AU - Chae,Shung-Chull, AU - Jeong,Myung-Ho, AU - ,, Y1 - 2008/07/26/ PY - 2008/03/07/received PY - 2008/06/02/revised PY - 2008/06/02/accepted PY - 2008/10/22/pubmed PY - 2008/11/7/medline PY - 2008/10/22/entrez SP - 957 EP - 65 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 102 IS - 8 N2 - The relation between body mass index (BMI) and waist-to-hip ratio (WHR) to clinical outcomes in patients with ST-segment elevation acute myocardial infarction (MI) has not been well described. As part of the Korean Acute MI Registry, we enrolled 3,734 eligible patients who were diagnosed with ST-segment elevation acute MI. The study population was categorized by BMI (into 4 groups according to the World Health Organization classification for the Asian population) and WHR (into 2 sets of 4 groups, 1 set for men and another for women, based on the INTERHEART study). Baseline characteristics and clinical outcomes were analyzed and compared among the BMI and WHR categories. Mean follow-up duration was 199 +/- 37 days. In the BMI category, underweight versus obese patients were older, were more likely to present with heart failure, and underwent guideline-based treatments less frequently. In the WHR category, the reverse trends were apparent for the latter factors except treatment-use frequencies. The highest mortality rate was observed in patients with the lowest BMI and the highest WHR. In an adjusted model, the highest WHR (hazard ratio 5.57, 95% confidence interval 1.53 to 12.29, p = 0.009) and the underweight (hazard ratio 2.88, 95% confidence interval 1.17 to 6.08, p = 0.021) categories within the 2 anthropometric indexes remained as mortality risk factors. In conclusion, the relation between obesity and prognosis after ST-segment elevation acute MI appears complex and should be further assessed in larger population-based cohort studies to determine the associations apparent in this study. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/18929693/Impact_of_body_mass_index_and_waist_to_hip_ratio_on_clinical_outcomes_in_patients_with_ST_segment_elevation_acute_myocardial_infarction__from_the_Korean_Acute_Myocardial_Infarction_Registry__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(08)01009-6 DB - PRIME DP - Unbound Medicine ER -