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Diet and dietary supplement intervention trials for the prevention of prostate cancer recurrence: a review of the randomized controlled trial evidence.
J Urol 2008; 180(6):2314-21; discussion 2721-2JU

Abstract

PURPOSE

We review the effect of diet and dietary supplement interventions on prostate cancer progression, recurrence and survival.

MATERIALS AND METHODS

A literature search was conducted in MEDLINE, EMBASE and CINAHL to identify diet and dietary supplement intervention studies in men with prostate cancer using prostate specific antigen or prostate specific antigen doubling time as a surrogate serum biomarker of prostate cancer recurrence and/or survival.

RESULTS

Of the 32 studies identified 9 (28%) were randomized controlled trials and the focus of this review. In these studies men had confirmed prostate cancer and elevated or increasing prostate specific antigen. Only 1 trial included men with metastatic disease. When body mass index was reported, men were overweight or obese. A significant decrease in prostate specific antigen was observed in some studies using a low fat vegan diet, soy beverage or lycopene supplement. While not often reported as an end point, a significant increase in prostate specific antigen doubling time was observed in a study on lycopene supplementation. In only 1 randomized controlled trial in men undergoing orchiectomy was a survival end point of fewer deaths with lycopene supplementation reported.

CONCLUSIONS

A limited number of randomized controlled trials were identified in which diet and dietary supplement interventions appeared to slow disease progression in men with prostate cancer, although results vary. Studies were limited by reliance on the surrogate biomarker prostate specific antigen, sample size and study duration. Well designed trials are warranted to expand knowledge, replicate findings and further assess the impact of diet and dietary supplement interventions on recurrence and treatment associated morbidities.

Authors+Show Affiliations

British Columbia Cancer Agency, Vancouver, British Columbia, Canada. cvpatten@bccancer.bc.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18930254

Citation

Van Patten, Cheri L., et al. "Diet and Dietary Supplement Intervention Trials for the Prevention of Prostate Cancer Recurrence: a Review of the Randomized Controlled Trial Evidence." The Journal of Urology, vol. 180, no. 6, 2008, pp. 2314-21; discussion 2721-2.
Van Patten CL, de Boer JG, Tomlinson Guns ES. Diet and dietary supplement intervention trials for the prevention of prostate cancer recurrence: a review of the randomized controlled trial evidence. J Urol. 2008;180(6):2314-21; discussion 2721-2.
Van Patten, C. L., de Boer, J. G., & Tomlinson Guns, E. S. (2008). Diet and dietary supplement intervention trials for the prevention of prostate cancer recurrence: a review of the randomized controlled trial evidence. The Journal of Urology, 180(6), pp. 2314-21; discussion 2721-2. doi:10.1016/j.juro.2008.08.078.
Van Patten CL, de Boer JG, Tomlinson Guns ES. Diet and Dietary Supplement Intervention Trials for the Prevention of Prostate Cancer Recurrence: a Review of the Randomized Controlled Trial Evidence. J Urol. 2008;180(6):2314-21; discussion 2721-2. PubMed PMID: 18930254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and dietary supplement intervention trials for the prevention of prostate cancer recurrence: a review of the randomized controlled trial evidence. AU - Van Patten,Cheri L, AU - de Boer,Johan G, AU - Tomlinson Guns,Emma S, Y1 - 2008/10/18/ PY - 2008/04/17/received PY - 2008/10/22/pubmed PY - 2008/12/17/medline PY - 2008/10/22/entrez SP - 2314-21; discussion 2721-2 JF - The Journal of urology JO - J. Urol. VL - 180 IS - 6 N2 - PURPOSE: We review the effect of diet and dietary supplement interventions on prostate cancer progression, recurrence and survival. MATERIALS AND METHODS: A literature search was conducted in MEDLINE, EMBASE and CINAHL to identify diet and dietary supplement intervention studies in men with prostate cancer using prostate specific antigen or prostate specific antigen doubling time as a surrogate serum biomarker of prostate cancer recurrence and/or survival. RESULTS: Of the 32 studies identified 9 (28%) were randomized controlled trials and the focus of this review. In these studies men had confirmed prostate cancer and elevated or increasing prostate specific antigen. Only 1 trial included men with metastatic disease. When body mass index was reported, men were overweight or obese. A significant decrease in prostate specific antigen was observed in some studies using a low fat vegan diet, soy beverage or lycopene supplement. While not often reported as an end point, a significant increase in prostate specific antigen doubling time was observed in a study on lycopene supplementation. In only 1 randomized controlled trial in men undergoing orchiectomy was a survival end point of fewer deaths with lycopene supplementation reported. CONCLUSIONS: A limited number of randomized controlled trials were identified in which diet and dietary supplement interventions appeared to slow disease progression in men with prostate cancer, although results vary. Studies were limited by reliance on the surrogate biomarker prostate specific antigen, sample size and study duration. Well designed trials are warranted to expand knowledge, replicate findings and further assess the impact of diet and dietary supplement interventions on recurrence and treatment associated morbidities. SN - 1527-3792 UR - https://www.unboundmedicine.com/medline/citation/18930254/Diet_and_dietary_supplement_intervention_trials_for_the_prevention_of_prostate_cancer_recurrence:_a_review_of_the_randomized_controlled_trial_evidence_ L2 - https://www.jurology.com/doi/full/10.1016/j.juro.2008.08.078?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -