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Relationship of age-related concentrations of serum FSH and LH with bone mineral density, prevalence of osteoporosis in native Chinese women.
Clin Chim Acta. 2009 Feb; 400(1-2):8-13.CC

Abstract

BACKGROUND

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) may play an important role in bone mass regulation in postmenopausal women.

METHODS

A cross-sectional study of 699 healthy Chinese women, aged 20 to 82 y, was conducted. Serum FSH and LH and BMD were measured at the posteroanterior (PA) spine, lateral spine, total hip, and distal forearm.

RESULTS

The geometric mean values (+/-SD) of serum FSH and LH in premenopausal women were 3.94 +/- 2.08 and 7.51 +/- 2.58 IU/l, respectively, and in postmenopausal women were 28.8 +/- 1.88 and 25.6 +/- 1.95 IU/l, respectively. The correlation of FSH to BMD at different skeletal regions (r = -0.597 - -0.492, P = 0.000) was higher than that of LH to BMD (r = -0.452 - -0.332, P = 0.000). The prevalences of osteoporosis for the quartiles of FSH at various skeletal sites were 0.57%, 0.43%, 27.1%, and 30.9%, respectively; and of LH were 2.14%, 4.43%, 19.5%, and 26.0%, respectively. The prevalence of osteoporosis in 3rd and 4th quartile was more significantly increased than the 1st and 2nd quartile.

CONCLUSIONS

These data suggest that FSH and LH levels in circulation are associated with BMD changes and osteoporosis occurrence in Chinese women.

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Publisher Full Text

Authors+Show Affiliations

Xu ZR
Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, 139 Renmin-Zhong Rd, Changsha, Hunan 410011, PR China.
Wang AH
No affiliation info available
Wu XP
No affiliation info available
Zhang H
No affiliation info available
Sheng ZF
No affiliation info available
Wu XY
No affiliation info available
Xie H
No affiliation info available
Luo XH
No affiliation info available
Liao EY
No affiliation info available

MeSH

AdultAge DistributionAgedAged, 80 and overAgingAsian Continental Ancestry GroupBone DensityChinaCross-Sectional StudiesFemaleFollicle Stimulating HormoneHealthHumansLuteinizing HormoneMiddle AgedOsteoporosisPrevalenceRisk

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18930719

Citation

Xu, Zhang-Rong, et al. "Relationship of Age-related Concentrations of Serum FSH and LH With Bone Mineral Density, Prevalence of Osteoporosis in Native Chinese Women." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 400, no. 1-2, 2009, pp. 8-13.
Xu ZR, Wang AH, Wu XP, et al. Relationship of age-related concentrations of serum FSH and LH with bone mineral density, prevalence of osteoporosis in native Chinese women. Clin Chim Acta. 2009;400(1-2):8-13.
Xu, Z. R., Wang, A. H., Wu, X. P., Zhang, H., Sheng, Z. F., Wu, X. Y., Xie, H., Luo, X. H., & Liao, E. Y. (2009). Relationship of age-related concentrations of serum FSH and LH with bone mineral density, prevalence of osteoporosis in native Chinese women. Clinica Chimica Acta; International Journal of Clinical Chemistry, 400(1-2), 8-13. https://doi.org/10.1016/j.cca.2008.09.027
Xu ZR, et al. Relationship of Age-related Concentrations of Serum FSH and LH With Bone Mineral Density, Prevalence of Osteoporosis in Native Chinese Women. Clin Chim Acta. 2009;400(1-2):8-13. PubMed PMID: 18930719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of age-related concentrations of serum FSH and LH with bone mineral density, prevalence of osteoporosis in native Chinese women. AU - Xu,Zhang-Rong, AU - Wang,Ai-Hong, AU - Wu,Xian-Ping, AU - Zhang,Hong, AU - Sheng,Zhi-Feng, AU - Wu,Xi-Yu, AU - Xie,Hui, AU - Luo,Xiang-Hang, AU - Liao,Er-Yuan, Y1 - 2008/10/07/ PY - 2008/07/09/received PY - 2008/09/09/revised PY - 2008/09/24/accepted PY - 2008/10/22/pubmed PY - 2009/2/14/medline PY - 2008/10/22/entrez SP - 8 EP - 13 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 400 IS - 1-2 N2 - BACKGROUND: Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) may play an important role in bone mass regulation in postmenopausal women. METHODS: A cross-sectional study of 699 healthy Chinese women, aged 20 to 82 y, was conducted. Serum FSH and LH and BMD were measured at the posteroanterior (PA) spine, lateral spine, total hip, and distal forearm. RESULTS: The geometric mean values (+/-SD) of serum FSH and LH in premenopausal women were 3.94 +/- 2.08 and 7.51 +/- 2.58 IU/l, respectively, and in postmenopausal women were 28.8 +/- 1.88 and 25.6 +/- 1.95 IU/l, respectively. The correlation of FSH to BMD at different skeletal regions (r = -0.597 - -0.492, P = 0.000) was higher than that of LH to BMD (r = -0.452 - -0.332, P = 0.000). The prevalences of osteoporosis for the quartiles of FSH at various skeletal sites were 0.57%, 0.43%, 27.1%, and 30.9%, respectively; and of LH were 2.14%, 4.43%, 19.5%, and 26.0%, respectively. The prevalence of osteoporosis in 3rd and 4th quartile was more significantly increased than the 1st and 2nd quartile. CONCLUSIONS: These data suggest that FSH and LH levels in circulation are associated with BMD changes and osteoporosis occurrence in Chinese women. SN - 1873-3492 UR - https://www.unboundmedicine.com/medline/citation/18930719/Relationship_of_age_related_concentrations_of_serum_FSH_and_LH_with_bone_mineral_density_prevalence_of_osteoporosis_in_native_Chinese_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(08)00480-4 DB - PRIME DP - Unbound Medicine ER -