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A novel concept in enteric coating: a double-coating system providing rapid drug release in the proximal small intestine.
J Control Release. 2009 Jan 19; 133(2):119-24.JC

Abstract

A novel double-coating enteric system was developed to accelerate drug release in conditions resembling the upper small intestine. The system comprises an inner coat (partially neutralised EUDRAGIT L 30 D-55 and organic acid) and an outer coat (standard EUDRAGIT L 30 D-55). Prednisolone tablets were coated with double layer formulations with inner coats neutralised to pH 5.6 in the presence of 10% citric acid or adipic acid. A conventional single coating was also applied for comparison purposes. There was no drug release from the single coated or double-coated tablets in 0.1M HCl for 2 h using USP II apparatus. The lag times of drug release in subsequent pH 5.6 phosphate buffer (to resemble the pH condition of the proximal small intestine) were 102, 42 and 28 min for the single coated, adipic acid and citric acid double-coated tablets respectively. The lag time for release from the double-coated tablets was further reduced to 5 min when the inner coat was neutralised to pH 6.0 in the presence of 10% citric acid. The rapid drug release from the double-coating system was associated with faster polymer dissolution rates compared to the single coating. The novel double-coated system has the potential to provide rapid drug release in the proximal small intestine, overcoming the limitations of conventional enteric coatings.

Authors+Show Affiliations

Department of Pharmaceutics, The School of Pharmacy, University of London, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18930772

Citation

Liu, Fang, et al. "A Novel Concept in Enteric Coating: a Double-coating System Providing Rapid Drug Release in the Proximal Small Intestine." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 133, no. 2, 2009, pp. 119-24.
Liu F, Lizio R, Meier C, et al. A novel concept in enteric coating: a double-coating system providing rapid drug release in the proximal small intestine. J Control Release. 2009;133(2):119-24.
Liu, F., Lizio, R., Meier, C., Petereit, H. U., Blakey, P., & Basit, A. W. (2009). A novel concept in enteric coating: a double-coating system providing rapid drug release in the proximal small intestine. Journal of Controlled Release : Official Journal of the Controlled Release Society, 133(2), 119-24. https://doi.org/10.1016/j.jconrel.2008.09.083
Liu F, et al. A Novel Concept in Enteric Coating: a Double-coating System Providing Rapid Drug Release in the Proximal Small Intestine. J Control Release. 2009 Jan 19;133(2):119-24. PubMed PMID: 18930772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel concept in enteric coating: a double-coating system providing rapid drug release in the proximal small intestine. AU - Liu,Fang, AU - Lizio,Rosario, AU - Meier,Christian, AU - Petereit,Hans-Ulrich, AU - Blakey,Peter, AU - Basit,Abdul W, Y1 - 2008/10/04/ PY - 2008/06/16/received PY - 2008/09/10/revised PY - 2008/09/19/accepted PY - 2008/10/22/entrez PY - 2008/10/22/pubmed PY - 2009/2/20/medline SP - 119 EP - 24 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 133 IS - 2 N2 - A novel double-coating enteric system was developed to accelerate drug release in conditions resembling the upper small intestine. The system comprises an inner coat (partially neutralised EUDRAGIT L 30 D-55 and organic acid) and an outer coat (standard EUDRAGIT L 30 D-55). Prednisolone tablets were coated with double layer formulations with inner coats neutralised to pH 5.6 in the presence of 10% citric acid or adipic acid. A conventional single coating was also applied for comparison purposes. There was no drug release from the single coated or double-coated tablets in 0.1M HCl for 2 h using USP II apparatus. The lag times of drug release in subsequent pH 5.6 phosphate buffer (to resemble the pH condition of the proximal small intestine) were 102, 42 and 28 min for the single coated, adipic acid and citric acid double-coated tablets respectively. The lag time for release from the double-coated tablets was further reduced to 5 min when the inner coat was neutralised to pH 6.0 in the presence of 10% citric acid. The rapid drug release from the double-coating system was associated with faster polymer dissolution rates compared to the single coating. The novel double-coated system has the potential to provide rapid drug release in the proximal small intestine, overcoming the limitations of conventional enteric coatings. SN - 1873-4995 UR - https://www.unboundmedicine.com/medline/citation/18930772/A_novel_concept_in_enteric_coating:_a_double_coating_system_providing_rapid_drug_release_in_the_proximal_small_intestine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-3659(08)00616-0 DB - PRIME DP - Unbound Medicine ER -