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Effect of starch 1500 as a binder and disintegrant in lamivudine tablets prepared by high shear wet granulation.
Pak J Pharm Sci. 2008 Oct; 21(4):455-9.PJ

Abstract

High shear wet granulation is a preferred manufacturing method of tablets. It allowed for rapid production of compressible granulations. The resultant granulation characteristics depend on a combination of formulation properties and processing parameters. Fully pregelatinized starches are currently being used as binders in wet granulated formulations. But due to the gelatinization, much of the disintegration properties are lost. Partially pregelatinized starches (starch 1,500) have a mixture of properties of both native and fully gelatinized starches; made them useful as both a binder and a disintegrant in wet granulated formulations. Starch 1,500 performed as an excellent binder producing a granulation that was compressible and produced lamivudine tablets of improved hardness and friability compared with those prepared with povidone. The formulation of lamivudine tablets with starch 1,500 exceeded the disintegration and dissolution performance of the povidone formulation that utilized a super disintegrant. High shear wet granulation is also well suited for the use of partially pregelatinized starches.

Authors+Show Affiliations

Rahman BM
Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh.
Ibne-Wahed MI
No affiliation info available
Khondkar P
No affiliation info available
Ahmed M
No affiliation info available
Islam R
No affiliation info available
Barman RK
No affiliation info available
Islam MA
No affiliation info available

MeSH

Chemistry, PharmaceuticalDrug CompoundingExcipientsGelatinHardnessLamivudineParticle SizePovidoneReverse Transcriptase InhibitorsSolubilityStarchTabletsTechnology, PharmaceuticalTime Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18930870

Citation

Rahman, Bytul M., et al. "Effect of Starch 1500 as a Binder and Disintegrant in Lamivudine Tablets Prepared By High Shear Wet Granulation." Pakistan Journal of Pharmaceutical Sciences, vol. 21, no. 4, 2008, pp. 455-9.
Rahman BM, Ibne-Wahed MI, Khondkar P, et al. Effect of starch 1500 as a binder and disintegrant in lamivudine tablets prepared by high shear wet granulation. Pak J Pharm Sci. 2008;21(4):455-9.
Rahman, B. M., Ibne-Wahed, M. I., Khondkar, P., Ahmed, M., Islam, R., Barman, R. K., & Islam, M. A. (2008). Effect of starch 1500 as a binder and disintegrant in lamivudine tablets prepared by high shear wet granulation. Pakistan Journal of Pharmaceutical Sciences, 21(4), 455-9.
Rahman BM, et al. Effect of Starch 1500 as a Binder and Disintegrant in Lamivudine Tablets Prepared By High Shear Wet Granulation. Pak J Pharm Sci. 2008;21(4):455-9. PubMed PMID: 18930870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of starch 1500 as a binder and disintegrant in lamivudine tablets prepared by high shear wet granulation. AU - Rahman,Bytul M, AU - Ibne-Wahed,Mir Imam, AU - Khondkar,Proma, AU - Ahmed,Maruf, AU - Islam,Robiul, AU - Barman,Ranjan K, AU - Islam,M Anwarul, PY - 2008/10/22/pubmed PY - 2008/12/23/medline PY - 2008/10/22/entrez SP - 455 EP - 9 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 21 IS - 4 N2 - High shear wet granulation is a preferred manufacturing method of tablets. It allowed for rapid production of compressible granulations. The resultant granulation characteristics depend on a combination of formulation properties and processing parameters. Fully pregelatinized starches are currently being used as binders in wet granulated formulations. But due to the gelatinization, much of the disintegration properties are lost. Partially pregelatinized starches (starch 1,500) have a mixture of properties of both native and fully gelatinized starches; made them useful as both a binder and a disintegrant in wet granulated formulations. Starch 1,500 performed as an excellent binder producing a granulation that was compressible and produced lamivudine tablets of improved hardness and friability compared with those prepared with povidone. The formulation of lamivudine tablets with starch 1,500 exceeded the disintegration and dissolution performance of the povidone formulation that utilized a super disintegrant. High shear wet granulation is also well suited for the use of partially pregelatinized starches. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/18930870/Effect_of_starch_1500_as_a_binder_and_disintegrant_in_lamivudine_tablets_prepared_by_high_shear_wet_granulation_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:18930870 DB - PRIME DP - Unbound Medicine ER -