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Long-term evolution and changing associations of left ventricular hypertrophy after starting hemodialysis.
Nephron Clin Pract. 2008; 110(2):c126-32.NC

Abstract

BACKGROUND/AIMS

Left ventricular hypertrophy (LVH) is prevalent in dialysis patients and is recognized as a potent risk factor for cardiovascular diseases. We examined the evolution of LVH after starting dialysis and the determinants of changes in LV mass.

METHODS

A cohort of 107 patients who had two or more echocardiograms at yearly intervals after starting hemodialysis was studied.

RESULTS

At baseline, the mean LV mass index (LVMI) was 145.8 g/m(2) and 73 (68%) patients had LVH. During the mean follow-up period of 34.5 months, LVMI decreased by 3.9 g/m(2). At last follow-up, the mean LVMI was 141.5 g/m(2) and 68 (64%) patients had LVH. For changes in LVMI, a significant correlation was found in changes in systolic blood pressure, LVMI at baseline, changes in serum albumin concentration, and age. The relationship between changes in LVMI and systolic blood pressure was close during the 1st and 2nd intervals, but became weak gradually during the 3rd and 4th intervals.

CONCLUSION

Many patients had LVH at starting hemodialysis and continued to have LVH thereafter. The most important determinants of LV mass changes were baseline LV mass and systolic blood pressure control, but the grade of reduction decreased gradually with time. These results suggest that active antihypertensive treatment should be started early to regress LVH and prevent cardiovascular diseases.

Authors+Show Affiliations

Kidney Center, Tsuchiura Kyodo General Hospital, Ibaraki, Japan. atakeda@midorino.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

18931516

Citation

Takeda, Atsushi, et al. "Long-term Evolution and Changing Associations of Left Ventricular Hypertrophy After Starting Hemodialysis." Nephron. Clinical Practice, vol. 110, no. 2, 2008, pp. c126-32.
Takeda A, Toda T, Iwamoto H, et al. Long-term evolution and changing associations of left ventricular hypertrophy after starting hemodialysis. Nephron Clin Pract. 2008;110(2):c126-32.
Takeda, A., Toda, T., Iwamoto, H., Watanabe, K., & Matsui, N. (2008). Long-term evolution and changing associations of left ventricular hypertrophy after starting hemodialysis. Nephron. Clinical Practice, 110(2), c126-32. https://doi.org/10.1159/000163845
Takeda A, et al. Long-term Evolution and Changing Associations of Left Ventricular Hypertrophy After Starting Hemodialysis. Nephron Clin Pract. 2008;110(2):c126-32. PubMed PMID: 18931516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term evolution and changing associations of left ventricular hypertrophy after starting hemodialysis. AU - Takeda,Atsushi, AU - Toda,Takayuki, AU - Iwamoto,Hitoshi, AU - Watanabe,Kotaro, AU - Matsui,Noriaki, Y1 - 2008/10/16/ PY - 2007/06/28/received PY - 2008/06/04/accepted PY - 2008/10/22/pubmed PY - 2009/2/12/medline PY - 2008/10/22/entrez SP - c126 EP - 32 JF - Nephron. Clinical practice JO - Nephron Clin Pract VL - 110 IS - 2 N2 - BACKGROUND/AIMS: Left ventricular hypertrophy (LVH) is prevalent in dialysis patients and is recognized as a potent risk factor for cardiovascular diseases. We examined the evolution of LVH after starting dialysis and the determinants of changes in LV mass. METHODS: A cohort of 107 patients who had two or more echocardiograms at yearly intervals after starting hemodialysis was studied. RESULTS: At baseline, the mean LV mass index (LVMI) was 145.8 g/m(2) and 73 (68%) patients had LVH. During the mean follow-up period of 34.5 months, LVMI decreased by 3.9 g/m(2). At last follow-up, the mean LVMI was 141.5 g/m(2) and 68 (64%) patients had LVH. For changes in LVMI, a significant correlation was found in changes in systolic blood pressure, LVMI at baseline, changes in serum albumin concentration, and age. The relationship between changes in LVMI and systolic blood pressure was close during the 1st and 2nd intervals, but became weak gradually during the 3rd and 4th intervals. CONCLUSION: Many patients had LVH at starting hemodialysis and continued to have LVH thereafter. The most important determinants of LV mass changes were baseline LV mass and systolic blood pressure control, but the grade of reduction decreased gradually with time. These results suggest that active antihypertensive treatment should be started early to regress LVH and prevent cardiovascular diseases. SN - 1660-2110 UR - https://www.unboundmedicine.com/medline/citation/18931516/Long_term_evolution_and_changing_associations_of_left_ventricular_hypertrophy_after_starting_hemodialysis_ L2 - https://www.karger.com?DOI=10.1159/000163845 DB - PRIME DP - Unbound Medicine ER -