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Procyanidins from Myrothamnus flabellifolia.
Nat Prod Res. 2008; 22(14):1237-48.NP

Abstract

From the ethyl acetate soluble fraction of an acetone-water extract of the twig tips of Myrothamnus flabellifolia Welw. (Myrothamnaceae), a variety of flavan-3-ols (epicatechin, epigallocatechin and their 3-O-galloylated analogues) and procyanidins (DP <or= 3) were isolated and identified for the first time: Procyanidin B3 [catechin-(4alpha --> 8)-catechin], B4 [catechin-(4alpha --> 8)-epicatechin], B6 [catechin-(4alpha --> 6)-catechin] and catechin-(4alpha --> 8)-epigallocatechin along with the galloylated analogues B4-3'-O-gallate, procyanidin B2-3'-O-gallate [epicatechin-(4beta --> 8)-epicatechin-3-O-gallate], B2-3,3'-di-O-gallate, procyanidin B5-3,3'-O-gallate [epicatechin-3-O-gallate-(4beta --> 6)-epicatechin-3-O-gallate], catechin-(4alpha --> 8)-epigallocatechin-3-O-gallate, the trimer procyanidin C1-3''-O-gallate[epicatechin-(4beta --> 8)-epicatechin-(4beta --> 8)-epicatechin-3-O-gallate] and the new epicatechin-3-O-gallate-(4beta --> 6)-epicatechin-3-O-p-hydroxybenzoate. The structures were elucidated by 1D- and 2D-NMR experiments of their peracetylated derivatives, partial acid-catalysed degradation with phloroglucinol, ESI-MS and CD spectra.

Authors+Show Affiliations

Institut für Pharmazeutische Biologie und Phytochemie,Westfalische Wilhelms-Universität, Münster, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18932087

Citation

Anke, Jennifer, et al. "Procyanidins From Myrothamnus Flabellifolia." Natural Product Research, vol. 22, no. 14, 2008, pp. 1237-48.
Anke J, Petereit F, Engelhardt C, et al. Procyanidins from Myrothamnus flabellifolia. Nat Prod Res. 2008;22(14):1237-48.
Anke, J., Petereit, F., Engelhardt, C., & Hensel, A. (2008). Procyanidins from Myrothamnus flabellifolia. Natural Product Research, 22(14), 1237-48. https://doi.org/10.1080/14786410701726343
Anke J, et al. Procyanidins From Myrothamnus Flabellifolia. Nat Prod Res. 2008;22(14):1237-48. PubMed PMID: 18932087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Procyanidins from Myrothamnus flabellifolia. AU - Anke,Jennifer, AU - Petereit,Frank, AU - Engelhardt,Claudia, AU - Hensel,Andreas, PY - 2008/10/22/pubmed PY - 2008/12/30/medline PY - 2008/10/22/entrez SP - 1237 EP - 48 JF - Natural product research JO - Nat Prod Res VL - 22 IS - 14 N2 - From the ethyl acetate soluble fraction of an acetone-water extract of the twig tips of Myrothamnus flabellifolia Welw. (Myrothamnaceae), a variety of flavan-3-ols (epicatechin, epigallocatechin and their 3-O-galloylated analogues) and procyanidins (DP <or= 3) were isolated and identified for the first time: Procyanidin B3 [catechin-(4alpha --> 8)-catechin], B4 [catechin-(4alpha --> 8)-epicatechin], B6 [catechin-(4alpha --> 6)-catechin] and catechin-(4alpha --> 8)-epigallocatechin along with the galloylated analogues B4-3'-O-gallate, procyanidin B2-3'-O-gallate [epicatechin-(4beta --> 8)-epicatechin-3-O-gallate], B2-3,3'-di-O-gallate, procyanidin B5-3,3'-O-gallate [epicatechin-3-O-gallate-(4beta --> 6)-epicatechin-3-O-gallate], catechin-(4alpha --> 8)-epigallocatechin-3-O-gallate, the trimer procyanidin C1-3''-O-gallate[epicatechin-(4beta --> 8)-epicatechin-(4beta --> 8)-epicatechin-3-O-gallate] and the new epicatechin-3-O-gallate-(4beta --> 6)-epicatechin-3-O-p-hydroxybenzoate. The structures were elucidated by 1D- and 2D-NMR experiments of their peracetylated derivatives, partial acid-catalysed degradation with phloroglucinol, ESI-MS and CD spectra. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/18932087/Procyanidins_from_Myrothamnus_flabellifolia_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786410701726343 DB - PRIME DP - Unbound Medicine ER -