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Ovariectomy-induced hyperphagia does not modulate bone mineral density or bone strength in rats.
J Nutr. 2008 Nov; 138(11):2106-10.JN

Abstract

The ovariectomized (OVX) rat is a widely used animal model for the development of prevention and treatment strategies for postmenopausal osteoporosis. However, ovariectomy-induced hyperphagia results in weight gain and adiposity. To prevent potential protective effects of increased body weight on bone from confounding outcomes of preclinical studies, pair-feeding is used in some but not all studies to control food intake, but its importance is not well elucidated. We investigated if the type of feeding, pair-feeding vs. consumption of diet ad libitum, modulates bone mineral and bone strength in OVX rats. Three-month-old female Sprague-Dawley rats (n = 12/group) were randomized to 1) sham-operated control (SHAM); 2) OVX pair-fed (OVX-PF); and 3) OVX ad libitum (OVX-AL). For 14 wk, OVX-PF rats were pair-fed with the SHAM group and daily food intakes and weekly body weights were obtained. At necropsy, regional body composition was measured by dual energy X-ray absorptiometry. Bone mineral density (BMD) and biomechanical bone strength of femurs and lumbar vertebrae (LV) were also measured. OVX-AL rats had higher overall food intake (P < 0.01), final body weight (P < 0.01), weight gain (P < 0.01), and fat mass (P < 0.05) than either SHAM and OVX-PF rats. Conversely, SHAM rats had higher femur (P < 0.001) and LV1-3 BMD (P < 0.001) as well as LV4 peak load (P < 0.01) than both the OVX groups, whereas bone outcomes did not differ between the OVX-PF and OVX-AL groups. In summary, ovariectomy-induced hyperphagia and weight gain do not modulate BMD or biomechanical strength at 14 wk postovariectomy, suggesting that pair-feeding is not essential.

Authors+Show Affiliations

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18936205

Citation

Jiang, Jessica M Y., et al. "Ovariectomy-induced Hyperphagia Does Not Modulate Bone Mineral Density or Bone Strength in Rats." The Journal of Nutrition, vol. 138, no. 11, 2008, pp. 2106-10.
Jiang JM, Sacco SM, Ward WE. Ovariectomy-induced hyperphagia does not modulate bone mineral density or bone strength in rats. J Nutr. 2008;138(11):2106-10.
Jiang, J. M., Sacco, S. M., & Ward, W. E. (2008). Ovariectomy-induced hyperphagia does not modulate bone mineral density or bone strength in rats. The Journal of Nutrition, 138(11), 2106-10. https://doi.org/10.3945/jn.108.093781
Jiang JM, Sacco SM, Ward WE. Ovariectomy-induced Hyperphagia Does Not Modulate Bone Mineral Density or Bone Strength in Rats. J Nutr. 2008;138(11):2106-10. PubMed PMID: 18936205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ovariectomy-induced hyperphagia does not modulate bone mineral density or bone strength in rats. AU - Jiang,Jessica M Y, AU - Sacco,Sandra M, AU - Ward,Wendy E, PY - 2008/10/22/pubmed PY - 2008/12/17/medline PY - 2008/10/22/entrez SP - 2106 EP - 10 JF - The Journal of nutrition JO - J. Nutr. VL - 138 IS - 11 N2 - The ovariectomized (OVX) rat is a widely used animal model for the development of prevention and treatment strategies for postmenopausal osteoporosis. However, ovariectomy-induced hyperphagia results in weight gain and adiposity. To prevent potential protective effects of increased body weight on bone from confounding outcomes of preclinical studies, pair-feeding is used in some but not all studies to control food intake, but its importance is not well elucidated. We investigated if the type of feeding, pair-feeding vs. consumption of diet ad libitum, modulates bone mineral and bone strength in OVX rats. Three-month-old female Sprague-Dawley rats (n = 12/group) were randomized to 1) sham-operated control (SHAM); 2) OVX pair-fed (OVX-PF); and 3) OVX ad libitum (OVX-AL). For 14 wk, OVX-PF rats were pair-fed with the SHAM group and daily food intakes and weekly body weights were obtained. At necropsy, regional body composition was measured by dual energy X-ray absorptiometry. Bone mineral density (BMD) and biomechanical bone strength of femurs and lumbar vertebrae (LV) were also measured. OVX-AL rats had higher overall food intake (P < 0.01), final body weight (P < 0.01), weight gain (P < 0.01), and fat mass (P < 0.05) than either SHAM and OVX-PF rats. Conversely, SHAM rats had higher femur (P < 0.001) and LV1-3 BMD (P < 0.001) as well as LV4 peak load (P < 0.01) than both the OVX groups, whereas bone outcomes did not differ between the OVX-PF and OVX-AL groups. In summary, ovariectomy-induced hyperphagia and weight gain do not modulate BMD or biomechanical strength at 14 wk postovariectomy, suggesting that pair-feeding is not essential. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/18936205/Ovariectomy_induced_hyperphagia_does_not_modulate_bone_mineral_density_or_bone_strength_in_rats_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.108.093781 DB - PRIME DP - Unbound Medicine ER -