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The role of GnRH analogues in endometriosis-associated apoptosis and angiogenesis.
Gynecol Obstet Invest. 2008; 66 Suppl 1:10-8.GO

Abstract

It has been postulated that gonadotropin-releasing hormone (GnRH) analogues may act directly on endometrial cells and inhibit their growth and proliferation by regulation of apoptotic and angiogenic mechanisms. Eutopic endometrial cells from patients with endometriosis show an increased proliferation rate and are less susceptible to cell death by apoptosis than those from subjects without the disease. Notably, the GnRH analogue, leuprorelin, inhibits cell proliferation and increases the apoptotic rate in eutopic endometrial cell cultures, an effect that appears to be mediated by an increase in the expression of the pro-apoptotic proteins Bax and FasL and a decrease in the expression of the anti-apoptotic protein Bcl-2. Angiogenesis is an important process in the development of endometrial tissue, and it is regulated by vascular endothelial growth factors (VEGFs) and angiopoietins. VEGF levels are elevated in peritoneal fluid and endometriotic tissue from patients with endometriosis. In addition, it has been demonstrated that the expression of VEGF is potentiated by a variety of cytokines, including IL-1beta. Recent studies show that leuprorelin reduces the production of VEGF-A and IL-1beta in eutopic endometrial cell cultures, suggesting a mechanism by which it could inhibit the development of endometriosis. Thus, GnRH analogues appear to be effective in reducing the growth of endometrial cells, not only due to their classical pituitary endocrine effects, but also via a direct effect on the endometrial cells themselves.

Authors+Show Affiliations

Institute of Biology and Experimental Medicine, Buenos Aires, Argentina. mtesone@dna.uba.arNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18936547

Citation

Tesone, Marta, et al. "The Role of GnRH Analogues in Endometriosis-associated Apoptosis and Angiogenesis." Gynecologic and Obstetric Investigation, vol. 66 Suppl 1, 2008, pp. 10-8.
Tesone M, Bilotas M, Barañao RI, et al. The role of GnRH analogues in endometriosis-associated apoptosis and angiogenesis. Gynecol Obstet Invest. 2008;66 Suppl 1:10-8.
Tesone, M., Bilotas, M., Barañao, R. I., & Meresman, G. (2008). The role of GnRH analogues in endometriosis-associated apoptosis and angiogenesis. Gynecologic and Obstetric Investigation, 66 Suppl 1, 10-8. https://doi.org/10.1159/000148026
Tesone M, et al. The Role of GnRH Analogues in Endometriosis-associated Apoptosis and Angiogenesis. Gynecol Obstet Invest. 2008;66 Suppl 1:10-8. PubMed PMID: 18936547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of GnRH analogues in endometriosis-associated apoptosis and angiogenesis. AU - Tesone,Marta, AU - Bilotas,Mariela, AU - Barañao,Rosa Inés, AU - Meresman,Gabriela, Y1 - 2008/10/21/ PY - 2008/10/24/pubmed PY - 2008/11/15/medline PY - 2008/10/24/entrez SP - 10 EP - 8 JF - Gynecologic and obstetric investigation JO - Gynecol Obstet Invest VL - 66 Suppl 1 N2 - It has been postulated that gonadotropin-releasing hormone (GnRH) analogues may act directly on endometrial cells and inhibit their growth and proliferation by regulation of apoptotic and angiogenic mechanisms. Eutopic endometrial cells from patients with endometriosis show an increased proliferation rate and are less susceptible to cell death by apoptosis than those from subjects without the disease. Notably, the GnRH analogue, leuprorelin, inhibits cell proliferation and increases the apoptotic rate in eutopic endometrial cell cultures, an effect that appears to be mediated by an increase in the expression of the pro-apoptotic proteins Bax and FasL and a decrease in the expression of the anti-apoptotic protein Bcl-2. Angiogenesis is an important process in the development of endometrial tissue, and it is regulated by vascular endothelial growth factors (VEGFs) and angiopoietins. VEGF levels are elevated in peritoneal fluid and endometriotic tissue from patients with endometriosis. In addition, it has been demonstrated that the expression of VEGF is potentiated by a variety of cytokines, including IL-1beta. Recent studies show that leuprorelin reduces the production of VEGF-A and IL-1beta in eutopic endometrial cell cultures, suggesting a mechanism by which it could inhibit the development of endometriosis. Thus, GnRH analogues appear to be effective in reducing the growth of endometrial cells, not only due to their classical pituitary endocrine effects, but also via a direct effect on the endometrial cells themselves. SN - 1423-002X UR - https://www.unboundmedicine.com/medline/citation/18936547/The_role_of_GnRH_analogues_in_endometriosis_associated_apoptosis_and_angiogenesis_ L2 - https://www.karger.com?DOI=10.1159/000148026 DB - PRIME DP - Unbound Medicine ER -