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Saturated and trans fatty acids and coronary heart disease.
Curr Atheroscler Rep 2008; 10(6):460-6CA

Abstract

Dietary intake of both saturated and trans fatty acids has been associated with an increase in the risk of coronary heart disease (CHD). Evidence comes mainly from controlled dietary experiments with intermediate end points, such as blood lipoproteins, and from observational studies. A few small, randomized controlled trials with clinical end points have been carried out in which saturated fat was replaced with polyunsaturated fat, leading to a reduction in low-density lipoprotein cholesterol and a reduction in CHD risk. However, no such studies exist for trans fatty acids. More high-quality, randomized controlled trials on fatty acids and CHD are required, but public health recommendations to reduce intake of both saturated and trans fatty acids are appropriate based on the current evidence.

Authors+Show Affiliations

Nutrition and Metabolism Group, Centre for Clinical and Population Science, Queen's University Belfast, Lower Ground Floor, Pathology Building, Grosvenor Road, Belfast, BT12 6BJ, UK. j.woodside@qub.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18937892

Citation

Woodside, Jayne V., et al. "Saturated and Trans Fatty Acids and Coronary Heart Disease." Current Atherosclerosis Reports, vol. 10, no. 6, 2008, pp. 460-6.
Woodside JV, McKinley MC, Young IS. Saturated and trans fatty acids and coronary heart disease. Curr Atheroscler Rep. 2008;10(6):460-6.
Woodside, J. V., McKinley, M. C., & Young, I. S. (2008). Saturated and trans fatty acids and coronary heart disease. Current Atherosclerosis Reports, 10(6), pp. 460-6.
Woodside JV, McKinley MC, Young IS. Saturated and Trans Fatty Acids and Coronary Heart Disease. Curr Atheroscler Rep. 2008;10(6):460-6. PubMed PMID: 18937892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Saturated and trans fatty acids and coronary heart disease. AU - Woodside,Jayne V, AU - McKinley,Michelle C, AU - Young,Ian S, PY - 2008/10/22/pubmed PY - 2009/1/3/medline PY - 2008/10/22/entrez SP - 460 EP - 6 JF - Current atherosclerosis reports JO - Curr Atheroscler Rep VL - 10 IS - 6 N2 - Dietary intake of both saturated and trans fatty acids has been associated with an increase in the risk of coronary heart disease (CHD). Evidence comes mainly from controlled dietary experiments with intermediate end points, such as blood lipoproteins, and from observational studies. A few small, randomized controlled trials with clinical end points have been carried out in which saturated fat was replaced with polyunsaturated fat, leading to a reduction in low-density lipoprotein cholesterol and a reduction in CHD risk. However, no such studies exist for trans fatty acids. More high-quality, randomized controlled trials on fatty acids and CHD are required, but public health recommendations to reduce intake of both saturated and trans fatty acids are appropriate based on the current evidence. SN - 1534-6242 UR - https://www.unboundmedicine.com/medline/citation/18937892/Saturated_and_trans_fatty_acids_and_coronary_heart_disease_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -