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Underestimation of atypical ductal hyperplasia at sonographically guided core biopsy of the breast.
AJR Am J Roentgenol. 2008 Nov; 191(5):1347-51.AA

Abstract

OBJECTIVE

The purpose of this study was to determine the rate of underestimation of atypical ductal hyperplasia (ADH) at sonographically guided core biopsy of the breast and to identify the factors involved.

MATERIALS AND METHODS

We retrospectively reviewed 3,563 lesions con secutively evaluated with sonographically guided core biopsy between January 2002 and June 2006. Histologic analysis yielded ADH in 60 of the 3,563 lesions (1.7%). The rate of underestimation of ADH was determined by dividing the number of lesions that proved to be carcinoma at surgical excision by 44, the total number of lesions evaluated with excisional biopsy. Clinical, sonographic, and core biopsy features were analyzed to identify factors that affect the rate of underestimation of ADH.

RESULTS

The rate of underestimation of ADH was found to be 48% (21 of 44 lesions). Underestimation of ADH was significantly less frequent for lesions evaluated with 11-gauge vacuum-assisted biopsy than for lesions evaluated with 14-gauge automated gun biopsy (22% [four of 18 lesions] vs 65% [17 of 26 lesions], p = 0.012). The other clinical, sonographic, and biopsy features examined did not affect the rate of underestimation of ADH.

CONCLUSION

For sonographically guided core biopsy of the breast, the rate of underestimation of ADH was 48%. This rate was lower for lesions evaluated with 11-gauge vacuum-assisted biopsy (22%) than for those evaluated with 14-gauge automated gun biopsy (65%). This finding was particularly true of smaller lesions (< or = 2.0 cm) and for lesions of the mass-only type.

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Authors+Show Affiliations

Jang M
Department of Radiology, Clinical Research Institute, Institute of Radiation Medicine, Seoul National University Hospital, Seoul National University Medical Research Center, 28, Yongon-dong, Chongno-gu, Seoul, 100-744, Korea.
Cho N
No affiliation info available
Moon WK
No affiliation info available
Park JS
No affiliation info available
Seong MH
No affiliation info available
Park IA
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overBiopsy, Fine-NeedleBreast NeoplasmsCarcinoma, DuctalFalse Negative ReactionsFemaleHumansKoreaMiddle AgedPrevalenceReproducibility of ResultsSensitivity and SpecificityUltrasonography, Interventional

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18941067

Citation

Jang, Mijung, et al. "Underestimation of Atypical Ductal Hyperplasia at Sonographically Guided Core Biopsy of the Breast." AJR. American Journal of Roentgenology, vol. 191, no. 5, 2008, pp. 1347-51.
Jang M, Cho N, Moon WK, et al. Underestimation of atypical ductal hyperplasia at sonographically guided core biopsy of the breast. AJR Am J Roentgenol. 2008;191(5):1347-51.
Jang, M., Cho, N., Moon, W. K., Park, J. S., Seong, M. H., & Park, I. A. (2008). Underestimation of atypical ductal hyperplasia at sonographically guided core biopsy of the breast. AJR. American Journal of Roentgenology, 191(5), 1347-51. https://doi.org/10.2214/AJR.07.3643
Jang M, et al. Underestimation of Atypical Ductal Hyperplasia at Sonographically Guided Core Biopsy of the Breast. AJR Am J Roentgenol. 2008;191(5):1347-51. PubMed PMID: 18941067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Underestimation of atypical ductal hyperplasia at sonographically guided core biopsy of the breast. AU - Jang,Mijung, AU - Cho,Nariya, AU - Moon,Woo Kyung, AU - Park,Jeong Seon, AU - Seong,Min Hyun, AU - Park,In Ae, PY - 2008/10/23/pubmed PY - 2008/12/17/medline PY - 2008/10/23/entrez SP - 1347 EP - 51 JF - AJR. American journal of roentgenology JO - AJR Am J Roentgenol VL - 191 IS - 5 N2 - OBJECTIVE: The purpose of this study was to determine the rate of underestimation of atypical ductal hyperplasia (ADH) at sonographically guided core biopsy of the breast and to identify the factors involved. MATERIALS AND METHODS: We retrospectively reviewed 3,563 lesions con secutively evaluated with sonographically guided core biopsy between January 2002 and June 2006. Histologic analysis yielded ADH in 60 of the 3,563 lesions (1.7%). The rate of underestimation of ADH was determined by dividing the number of lesions that proved to be carcinoma at surgical excision by 44, the total number of lesions evaluated with excisional biopsy. Clinical, sonographic, and core biopsy features were analyzed to identify factors that affect the rate of underestimation of ADH. RESULTS: The rate of underestimation of ADH was found to be 48% (21 of 44 lesions). Underestimation of ADH was significantly less frequent for lesions evaluated with 11-gauge vacuum-assisted biopsy than for lesions evaluated with 14-gauge automated gun biopsy (22% [four of 18 lesions] vs 65% [17 of 26 lesions], p = 0.012). The other clinical, sonographic, and biopsy features examined did not affect the rate of underestimation of ADH. CONCLUSION: For sonographically guided core biopsy of the breast, the rate of underestimation of ADH was 48%. This rate was lower for lesions evaluated with 11-gauge vacuum-assisted biopsy (22%) than for those evaluated with 14-gauge automated gun biopsy (65%). This finding was particularly true of smaller lesions (< or = 2.0 cm) and for lesions of the mass-only type. SN - 1546-3141 UR - https://www.unboundmedicine.com/medline/citation/18941067/Underestimation_of_atypical_ductal_hyperplasia_at_sonographically_guided_core_biopsy_of_the_breast_ L2 - https://www.ajronline.org/doi/10.2214/AJR.07.3643 DB - PRIME DP - Unbound Medicine ER -