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Clinical manifestations of infants with nutritional vitamin B deficiency due to maternal dietary deficiency.
Acta Paediatr. 2009 Jan; 98(1):98-102.AP

Abstract

AIM

In developing countries, nutritional vitamin B(12) deficiency in infants due to maternal diet without adequate protein of animal origin has some characteristic clinical features. In this study, haematological, neurological and gastrointestinal characteristics of nutritional vitamin B(12) deficiency are presented.

METHODS

Hospital records of 27 infants diagnosed in a paediatric haematology unit between 2000 and 2008 were evaluated retrospectively.

RESULTS

The median age at diagnosis was 10.5 months (3-24 months). All the infants were exclusively breast fed and they presented with severe nonspecific manifestations, such as weakness, failure to thrive, refusal to wean, vomiting, developmental delay, irritability and tremor in addition to megaloblastic anaemia. The diagnosis was confirmed by complete blood counts, blood and marrow smears and serum vitamin B(12) and folic acid levels. The median haemoglobin level was 6.4 g/dL (3.1-10.6) and mean corpuscular volume (MCV) was 96.8 fL (73-112.3). Some patients also had thrombocytopaenia and neutropaenia. All the infants showed clinical and haematological improvement with vitamin B(12) administration. Patients with severe anaemia causing heart failure received packed red blood cell transfusions as the initial therapy.

CONCLUSION

Paediatricians must consider nutritional vitamin B(12) deficiency due to maternal dietary deficiency in the differential diagnosis of some gastrointestinal, haematological, developmental and neurological disorders of infants with poor socioeconomic status. Delay in diagnosis may cause irreversible neurological damage.

Authors+Show Affiliations

Department of Pediatrics, Division of Hematology, Kocaeli University, Kocaeli, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18945280

Citation

Zengin, E, et al. "Clinical Manifestations of Infants With Nutritional Vitamin B Deficiency Due to Maternal Dietary Deficiency." Acta Paediatrica (Oslo, Norway : 1992), vol. 98, no. 1, 2009, pp. 98-102.
Zengin E, Sarper N, Caki Kiliç S. Clinical manifestations of infants with nutritional vitamin B deficiency due to maternal dietary deficiency. Acta Paediatr. 2009;98(1):98-102.
Zengin, E., Sarper, N., & Caki Kiliç, S. (2009). Clinical manifestations of infants with nutritional vitamin B deficiency due to maternal dietary deficiency. Acta Paediatrica (Oslo, Norway : 1992), 98(1), 98-102. https://doi.org/10.1111/j.1651-2227.2008.01059.x
Zengin E, Sarper N, Caki Kiliç S. Clinical Manifestations of Infants With Nutritional Vitamin B Deficiency Due to Maternal Dietary Deficiency. Acta Paediatr. 2009;98(1):98-102. PubMed PMID: 18945280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical manifestations of infants with nutritional vitamin B deficiency due to maternal dietary deficiency. AU - Zengin,E, AU - Sarper,N, AU - Caki Kiliç,S, Y1 - 2008/10/06/ PY - 2008/10/24/entrez PY - 2008/10/24/pubmed PY - 2009/4/3/medline SP - 98 EP - 102 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr VL - 98 IS - 1 N2 - AIM: In developing countries, nutritional vitamin B(12) deficiency in infants due to maternal diet without adequate protein of animal origin has some characteristic clinical features. In this study, haematological, neurological and gastrointestinal characteristics of nutritional vitamin B(12) deficiency are presented. METHODS: Hospital records of 27 infants diagnosed in a paediatric haematology unit between 2000 and 2008 were evaluated retrospectively. RESULTS: The median age at diagnosis was 10.5 months (3-24 months). All the infants were exclusively breast fed and they presented with severe nonspecific manifestations, such as weakness, failure to thrive, refusal to wean, vomiting, developmental delay, irritability and tremor in addition to megaloblastic anaemia. The diagnosis was confirmed by complete blood counts, blood and marrow smears and serum vitamin B(12) and folic acid levels. The median haemoglobin level was 6.4 g/dL (3.1-10.6) and mean corpuscular volume (MCV) was 96.8 fL (73-112.3). Some patients also had thrombocytopaenia and neutropaenia. All the infants showed clinical and haematological improvement with vitamin B(12) administration. Patients with severe anaemia causing heart failure received packed red blood cell transfusions as the initial therapy. CONCLUSION: Paediatricians must consider nutritional vitamin B(12) deficiency due to maternal dietary deficiency in the differential diagnosis of some gastrointestinal, haematological, developmental and neurological disorders of infants with poor socioeconomic status. Delay in diagnosis may cause irreversible neurological damage. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/18945280/Clinical_manifestations_of_infants_with_nutritional_vitamin_B_deficiency_due_to_maternal_dietary_deficiency_ L2 - https://doi.org/10.1111/j.1651-2227.2008.01059.x DB - PRIME DP - Unbound Medicine ER -