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Unwanted pregnancy as a risk factor for offspring schizophrenia-spectrum and affective disorders in adulthood: a prospective high-risk study.
Psychol Med. 2009 Jun; 39(6):957-65.PM

Abstract

BACKGROUND

This study investigated whether 'unwanted pregnancy' (i.e. a negative or ambivalent attitude towards the pregnancy/reproduction) is associated with schizophrenia-spectrum and affective disorders in the offspring in adulthood, and if so, whether other pregnancy, perinatal, childhood or genetic-risk factors account for this association.

METHOD

In a prospective study beginning during pregnancy, unwanted pregnancy (in combination with other early life risk factors) was studied in relation to adult mental disorders in 75 genetic high-risk (HR) and 91 normal-risk (NR) offspring, defined through maternal psychosis history. Early life risk factors were studied through personal interviews, observations and medical records, and offspring mental disorders were independently diagnosed through follow-up examination at about 22 years of age.

RESULTS

Unwanted pregnancy by itself was significantly related to adult offspring schizophrenia-spectrum disorders in both the total sample and the HR subgroup, but the effect was found to be limited to the HR group and occurred in interaction with genetic risk. Other co-temporaneous pregnancy stressors and later perinatal complications, malformations and early childhood environmental stressors could not explain this relationship. Unwanted pregnancy also interacted with genetic-risk status in relating to affective disorders in the offspring.

CONCLUSIONS

Unwanted pregnancy, when occurring together with genetic risk for psychosis, was found to be related to both adult schizophrenia-spectrum and affective mental disorders in the offspring. Although the effect of unwanted pregnancy could be mediated by other yet-unidentified factors, unwanted pregnancy might be a functional, discrete environmental psychosocial factor with its own deleterious impact on offspring mental development, when co-occurring with genetic risk.

Authors+Show Affiliations

Department of Psychiatric Epidemiology, University Hospital, Lund, Sweden. thomas.mcneil@med.lu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18945377

Citation

McNeil, T F., et al. "Unwanted Pregnancy as a Risk Factor for Offspring Schizophrenia-spectrum and Affective Disorders in Adulthood: a Prospective High-risk Study." Psychological Medicine, vol. 39, no. 6, 2009, pp. 957-65.
McNeil TF, Schubert EW, Cantor-Graae E, et al. Unwanted pregnancy as a risk factor for offspring schizophrenia-spectrum and affective disorders in adulthood: a prospective high-risk study. Psychol Med. 2009;39(6):957-65.
McNeil, T. F., Schubert, E. W., Cantor-Graae, E., Brossner, M., Schubert, P., & Henriksson, K. M. (2009). Unwanted pregnancy as a risk factor for offspring schizophrenia-spectrum and affective disorders in adulthood: a prospective high-risk study. Psychological Medicine, 39(6), 957-65. https://doi.org/10.1017/S0033291708004479
McNeil TF, et al. Unwanted Pregnancy as a Risk Factor for Offspring Schizophrenia-spectrum and Affective Disorders in Adulthood: a Prospective High-risk Study. Psychol Med. 2009;39(6):957-65. PubMed PMID: 18945377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unwanted pregnancy as a risk factor for offspring schizophrenia-spectrum and affective disorders in adulthood: a prospective high-risk study. AU - McNeil,T F, AU - Schubert,E W, AU - Cantor-Graae,E, AU - Brossner,M, AU - Schubert,P, AU - Henriksson,K M, Y1 - 2008/10/23/ PY - 2008/10/24/pubmed PY - 2009/9/1/medline PY - 2008/10/24/entrez SP - 957 EP - 65 JF - Psychological medicine JO - Psychol Med VL - 39 IS - 6 N2 - BACKGROUND: This study investigated whether 'unwanted pregnancy' (i.e. a negative or ambivalent attitude towards the pregnancy/reproduction) is associated with schizophrenia-spectrum and affective disorders in the offspring in adulthood, and if so, whether other pregnancy, perinatal, childhood or genetic-risk factors account for this association. METHOD: In a prospective study beginning during pregnancy, unwanted pregnancy (in combination with other early life risk factors) was studied in relation to adult mental disorders in 75 genetic high-risk (HR) and 91 normal-risk (NR) offspring, defined through maternal psychosis history. Early life risk factors were studied through personal interviews, observations and medical records, and offspring mental disorders were independently diagnosed through follow-up examination at about 22 years of age. RESULTS: Unwanted pregnancy by itself was significantly related to adult offspring schizophrenia-spectrum disorders in both the total sample and the HR subgroup, but the effect was found to be limited to the HR group and occurred in interaction with genetic risk. Other co-temporaneous pregnancy stressors and later perinatal complications, malformations and early childhood environmental stressors could not explain this relationship. Unwanted pregnancy also interacted with genetic-risk status in relating to affective disorders in the offspring. CONCLUSIONS: Unwanted pregnancy, when occurring together with genetic risk for psychosis, was found to be related to both adult schizophrenia-spectrum and affective mental disorders in the offspring. Although the effect of unwanted pregnancy could be mediated by other yet-unidentified factors, unwanted pregnancy might be a functional, discrete environmental psychosocial factor with its own deleterious impact on offspring mental development, when co-occurring with genetic risk. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/18945377/Unwanted_pregnancy_as_a_risk_factor_for_offspring_schizophrenia_spectrum_and_affective_disorders_in_adulthood:_a_prospective_high_risk_study_ L2 - https://www.cambridge.org/core/product/identifier/S0033291708004479/type/journal_article DB - PRIME DP - Unbound Medicine ER -