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Relationship of apoE polymorphism with lipoprotein(a), apoA, apoB and lipid levels in atherosclerotic infarct.
J Neurol Sci. 2009 Feb 15; 277(1-2):17-21.JN

Abstract

BACKGROUND AND PURPOSE

Apolipoprotein E (apoE) polymorphism is suggested to be a risk factor in stroke in some populations, either by affecting lipid parameters or independently. Its effect on lipoprotein(a) [Lp(a)] is not known. The roles of apoE polymorphism and of high Lp(a) levels in atherosclerotic stroke (AS) in the Turkish population are unclear. Our aim was to investigate the relationship of apoE alleles and Lp(a) level with AS and the relationship of apoE alleles with Lp(a) and other lipid parameters.

METHODS

ApoE polymorphisms and lipid parameters were prospectively evaluated in 85 patients and 77 controls with normal brain imaging.

RESULTS

Only hypertension, diabetes mellitus, associated vascular diseases and decreased high-density lipoprotein cholesterol levels were found to be independent risk factors for stroke. However, in the presence of apoE/E4 allele, increased low-density lipoprotein cholesterol (LDL-chol), apolipoprotein B (apoB) and Lp(a) levels and in the presence of apo E/E3 allele, only Lp(a) levels were determined as risk factors.

CONCLUSION

This study showed that while apoE polymorphism was not a risk factor itself, high Lp(a), LDL-chol and apoB were determined to be risk factors in E3 or E4 carriers.

Authors+Show Affiliations

Department of Neurology, Zonguldak Karaelmas University Medical Faculty, Zonguldak, Turkey. doga24@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18945448

Citation

Tascilar, N, et al. "Relationship of apoE Polymorphism With Lipoprotein(a), apoA, apoB and Lipid Levels in Atherosclerotic Infarct." Journal of the Neurological Sciences, vol. 277, no. 1-2, 2009, pp. 17-21.
Tascilar N, Dursun A, Ankarali H, et al. Relationship of apoE polymorphism with lipoprotein(a), apoA, apoB and lipid levels in atherosclerotic infarct. J Neurol Sci. 2009;277(1-2):17-21.
Tascilar, N., Dursun, A., Ankarali, H., Mungan, G., Sumbuloglu, V., Ekem, S., Bozdogan, S., Baris, S., Aciman, E., & Cabuk, F. (2009). Relationship of apoE polymorphism with lipoprotein(a), apoA, apoB and lipid levels in atherosclerotic infarct. Journal of the Neurological Sciences, 277(1-2), 17-21. https://doi.org/10.1016/j.jns.2008.09.034
Tascilar N, et al. Relationship of apoE Polymorphism With Lipoprotein(a), apoA, apoB and Lipid Levels in Atherosclerotic Infarct. J Neurol Sci. 2009 Feb 15;277(1-2):17-21. PubMed PMID: 18945448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of apoE polymorphism with lipoprotein(a), apoA, apoB and lipid levels in atherosclerotic infarct. AU - Tascilar,N, AU - Dursun,A, AU - Ankarali,H, AU - Mungan,G, AU - Sumbuloglu,V, AU - Ekem,S, AU - Bozdogan,S, AU - Baris,S, AU - Aciman,E, AU - Cabuk,F, Y1 - 2008/10/21/ PY - 2008/07/24/received PY - 2008/09/20/revised PY - 2008/09/25/accepted PY - 2008/10/24/pubmed PY - 2009/4/3/medline PY - 2008/10/24/entrez SP - 17 EP - 21 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 277 IS - 1-2 N2 - BACKGROUND AND PURPOSE: Apolipoprotein E (apoE) polymorphism is suggested to be a risk factor in stroke in some populations, either by affecting lipid parameters or independently. Its effect on lipoprotein(a) [Lp(a)] is not known. The roles of apoE polymorphism and of high Lp(a) levels in atherosclerotic stroke (AS) in the Turkish population are unclear. Our aim was to investigate the relationship of apoE alleles and Lp(a) level with AS and the relationship of apoE alleles with Lp(a) and other lipid parameters. METHODS: ApoE polymorphisms and lipid parameters were prospectively evaluated in 85 patients and 77 controls with normal brain imaging. RESULTS: Only hypertension, diabetes mellitus, associated vascular diseases and decreased high-density lipoprotein cholesterol levels were found to be independent risk factors for stroke. However, in the presence of apoE/E4 allele, increased low-density lipoprotein cholesterol (LDL-chol), apolipoprotein B (apoB) and Lp(a) levels and in the presence of apo E/E3 allele, only Lp(a) levels were determined as risk factors. CONCLUSION: This study showed that while apoE polymorphism was not a risk factor itself, high Lp(a), LDL-chol and apoB were determined to be risk factors in E3 or E4 carriers. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/18945448/Relationship_of_apoE_polymorphism_with_lipoprotein_a__apoA_apoB_and_lipid_levels_in_atherosclerotic_infarct_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(08)00503-0 DB - PRIME DP - Unbound Medicine ER -