Tags

Type your tag names separated by a space and hit enter

The influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon.
Int J Food Microbiol. 2008 Dec 10; 128(2):406-10.IJ

Abstract

The bacterial enzymes beta-glucosidase, beta-glucuronidase, and urease may contribute to the development of colon cancer by generating carcinogens. A reduction in the activity of these enzymes by certain lactic acid bacteria is considered to be beneficial. This study examined fecal beta-glucosidase, beta-glucuronidase, and urease activities during administration of Lactobacillus rhamnosus LC705 (LC705) together with Propionibacterium freudenreichii ssp shermanii JS (PJS). Thirty-eight healthy men participated in this randomized, double-blind, placebo-controlled, two-period crossover study with treatment periods of 4 weeks. Subjects consumed daily bacterial or placebo capsules. Bacterial capsules contained viable LC705 and PJS (2x10(10) CFU of each strain daily). The activities of beta-glucosidase, beta-glucuronidase and urease, recovery of LC705 and PJS, and counts of total lactobacilli and propionibacteria were determined from feces. The mean fecal counts of total lactobacilli and propionibacteria as well as strains LC705 and PJS were significantly increased during the administration of bacteria (3.5-, 13-, 80- and 11-fold, respectively). beta-glucosidase activity decreased by 10% (P=0.18) and urease activity by 13% (P=0.16) during bacterial supplementation versus placebo. The change in beta-glucosidase activity was negatively correlated with the change in propionibacteria counts (R=-0.350, P=0.039), being -2.68 versus 0.94 nmol/min/mg protein in subjects with increased and unchanged/decreased propionibacteria, respectively (P=0.003). To conclude, the administration of LC705 and PJS was followed by an increase in the fecal counts of lactobacilli and propionibacteria and a decrease in the activity of beta-glucosidase with increasing counts of propionibacteria.

Authors+Show Affiliations

Valio Ltd, R&D, P.O. Box 30, FIN-00039 Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18945506

Citation

Hatakka, Katja, et al. "The Influence of Lactobacillus Rhamnosus LC705 Together With Propionibacterium Freudenreichii Ssp. Shermanii JS On Potentially Carcinogenic Bacterial Activity in Human Colon." International Journal of Food Microbiology, vol. 128, no. 2, 2008, pp. 406-10.
Hatakka K, Holma R, El-Nezami H, et al. The influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon. Int J Food Microbiol. 2008;128(2):406-10.
Hatakka, K., Holma, R., El-Nezami, H., Suomalainen, T., Kuisma, M., Saxelin, M., Poussa, T., Mykkänen, H., & Korpela, R. (2008). The influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon. International Journal of Food Microbiology, 128(2), 406-10. https://doi.org/10.1016/j.ijfoodmicro.2008.09.010
Hatakka K, et al. The Influence of Lactobacillus Rhamnosus LC705 Together With Propionibacterium Freudenreichii Ssp. Shermanii JS On Potentially Carcinogenic Bacterial Activity in Human Colon. Int J Food Microbiol. 2008 Dec 10;128(2):406-10. PubMed PMID: 18945506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon. AU - Hatakka,Katja, AU - Holma,Reetta, AU - El-Nezami,Hani, AU - Suomalainen,Tarja, AU - Kuisma,Minna, AU - Saxelin,Maija, AU - Poussa,Tuija, AU - Mykkänen,Hannu, AU - Korpela,Riitta, Y1 - 2008/09/27/ PY - 2008/06/05/received PY - 2008/08/13/revised PY - 2008/09/21/accepted PY - 2008/10/24/pubmed PY - 2009/1/30/medline PY - 2008/10/24/entrez SP - 406 EP - 10 JF - International journal of food microbiology JO - Int J Food Microbiol VL - 128 IS - 2 N2 - The bacterial enzymes beta-glucosidase, beta-glucuronidase, and urease may contribute to the development of colon cancer by generating carcinogens. A reduction in the activity of these enzymes by certain lactic acid bacteria is considered to be beneficial. This study examined fecal beta-glucosidase, beta-glucuronidase, and urease activities during administration of Lactobacillus rhamnosus LC705 (LC705) together with Propionibacterium freudenreichii ssp shermanii JS (PJS). Thirty-eight healthy men participated in this randomized, double-blind, placebo-controlled, two-period crossover study with treatment periods of 4 weeks. Subjects consumed daily bacterial or placebo capsules. Bacterial capsules contained viable LC705 and PJS (2x10(10) CFU of each strain daily). The activities of beta-glucosidase, beta-glucuronidase and urease, recovery of LC705 and PJS, and counts of total lactobacilli and propionibacteria were determined from feces. The mean fecal counts of total lactobacilli and propionibacteria as well as strains LC705 and PJS were significantly increased during the administration of bacteria (3.5-, 13-, 80- and 11-fold, respectively). beta-glucosidase activity decreased by 10% (P=0.18) and urease activity by 13% (P=0.16) during bacterial supplementation versus placebo. The change in beta-glucosidase activity was negatively correlated with the change in propionibacteria counts (R=-0.350, P=0.039), being -2.68 versus 0.94 nmol/min/mg protein in subjects with increased and unchanged/decreased propionibacteria, respectively (P=0.003). To conclude, the administration of LC705 and PJS was followed by an increase in the fecal counts of lactobacilli and propionibacteria and a decrease in the activity of beta-glucosidase with increasing counts of propionibacteria. SN - 0168-1605 UR - https://www.unboundmedicine.com/medline/citation/18945506/The_influence_of_Lactobacillus_rhamnosus_LC705_together_with_Propionibacterium_freudenreichii_ssp__shermanii_JS_on_potentially_carcinogenic_bacterial_activity_in_human_colon_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1605(08)00517-5 DB - PRIME DP - Unbound Medicine ER -