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Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the Three-City Study.
Diabetes Care. 2009 Jan; 32(1):169-74.DC

Abstract

OBJECTIVE

Associations between metabolic syndrome and its individual components with risk of incident dementia and its different subtypes are inconsistent.

RESEARCH DESIGN AND METHODS

The 7,087 community-dwelling subjects aged > or =65 years were recruited from the French Three-City (3C) cohort. Hazard ratios (over 4 years) of incident dementia and its subtypes (vascular dementia and Alzheimer's disease) and association with metabolic syndrome (defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria) and its individual components (hypertension, large waist circumference, high triglycerides, low HDL cholesterol, and elevated fasting glycemia) were estimated in separate Cox proportional hazard models.

RESULTS

Metabolic syndrome was present in 15.8% of the study participants. The presence of metabolic syndrome increased the risk of incident vascular dementia but not Alzheimer's disease over 4 years, independent of sociodemographic characteristics and the apolipoprotein (apo) Eepsilon4 allele. High triglyceride level was the only component of metabolic syndrome that was significantly associated with the incidence of all-cause (hazard ratio 1.45 [95% CI 1.05-2.00]; P = 0.02) and vascular (2.27 [1.16-4.42]; P = 0.02) dementia, even after adjustment of the apoE genotype. Diabetes, but not impaired fasting glycemia, was significantly associated with all-cause (1.58 [1.05-2.38]; P = 0.03) and vascular (2.53 [1.15-5.66]; P = 0.03) dementia.

CONCLUSIONS

The observed relation between high triglycerides, diabetes, and vascular dementia emphasizes the need for detection and treatment of vascular risk factors in older individuals in order to prevent the likelihood of clinical dementia.

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Authors+Show Affiliations

Raffaitin C
Diabetology-Nutrition Unit, University Hospital of Bordeaux, Pessac, France. christelle.raffaitin@isped.u-bordeaux2.fr
Gin H
No affiliation info available
Empana JP
No affiliation info available
Helmer C
No affiliation info available
Berr C
No affiliation info available
Tzourio C
No affiliation info available
Portet F
No affiliation info available
Dartigues JF
No affiliation info available
Alpérovitch A
No affiliation info available
Barberger-Gateau P
No affiliation info available

MeSH

AgedAlzheimer DiseaseApolipoprotein E4Cholesterol, HDLCohort StudiesDementia, VascularDiabetes ComplicationsFemaleFranceHumansHyperglycemiaHypertensionIncidenceMaleMetabolic SyndromeProportional Hazards ModelsTriglyceridesUrban Population

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18945929

Citation

Raffaitin, Christelle, et al. "Metabolic Syndrome and Risk for Incident Alzheimer's Disease or Vascular Dementia: the Three-City Study." Diabetes Care, vol. 32, no. 1, 2009, pp. 169-74.
Raffaitin C, Gin H, Empana JP, et al. Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the Three-City Study. Diabetes Care. 2009;32(1):169-74.
Raffaitin, C., Gin, H., Empana, J. P., Helmer, C., Berr, C., Tzourio, C., Portet, F., Dartigues, J. F., Alpérovitch, A., & Barberger-Gateau, P. (2009). Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the Three-City Study. Diabetes Care, 32(1), 169-74. https://doi.org/10.2337/dc08-0272
Raffaitin C, et al. Metabolic Syndrome and Risk for Incident Alzheimer's Disease or Vascular Dementia: the Three-City Study. Diabetes Care. 2009;32(1):169-74. PubMed PMID: 18945929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the Three-City Study. AU - Raffaitin,Christelle, AU - Gin,Henri, AU - Empana,Jean-Philippe, AU - Helmer,Catherine, AU - Berr,Claudine, AU - Tzourio,Christophe, AU - Portet,Florence, AU - Dartigues,Jean-François, AU - Alpérovitch,Annick, AU - Barberger-Gateau,Pascale, Y1 - 2008/10/22/ PY - 2008/10/24/pubmed PY - 2013/1/4/medline PY - 2008/10/24/entrez SP - 169 EP - 74 JF - Diabetes care JO - Diabetes Care VL - 32 IS - 1 N2 - OBJECTIVE: Associations between metabolic syndrome and its individual components with risk of incident dementia and its different subtypes are inconsistent. RESEARCH DESIGN AND METHODS: The 7,087 community-dwelling subjects aged > or =65 years were recruited from the French Three-City (3C) cohort. Hazard ratios (over 4 years) of incident dementia and its subtypes (vascular dementia and Alzheimer's disease) and association with metabolic syndrome (defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria) and its individual components (hypertension, large waist circumference, high triglycerides, low HDL cholesterol, and elevated fasting glycemia) were estimated in separate Cox proportional hazard models. RESULTS: Metabolic syndrome was present in 15.8% of the study participants. The presence of metabolic syndrome increased the risk of incident vascular dementia but not Alzheimer's disease over 4 years, independent of sociodemographic characteristics and the apolipoprotein (apo) Eepsilon4 allele. High triglyceride level was the only component of metabolic syndrome that was significantly associated with the incidence of all-cause (hazard ratio 1.45 [95% CI 1.05-2.00]; P = 0.02) and vascular (2.27 [1.16-4.42]; P = 0.02) dementia, even after adjustment of the apoE genotype. Diabetes, but not impaired fasting glycemia, was significantly associated with all-cause (1.58 [1.05-2.38]; P = 0.03) and vascular (2.53 [1.15-5.66]; P = 0.03) dementia. CONCLUSIONS: The observed relation between high triglycerides, diabetes, and vascular dementia emphasizes the need for detection and treatment of vascular risk factors in older individuals in order to prevent the likelihood of clinical dementia. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/18945929/Metabolic_syndrome_and_risk_for_incident_Alzheimer's_disease_or_vascular_dementia:_the_Three_City_Study_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=18945929 DB - PRIME DP - Unbound Medicine ER -