Tags

Type your tag names separated by a space and hit enter

Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats.
Singapore Med J. 2008 Oct; 49(10):800-4.SM

Abstract

INTRODUCTION

The present study investigated the possible therapeutic effects of Annona squamosa (A. squamosa) extract on certain biochemical markers in streptozotocin (STZ)-induced diabetes mellitus in rats.

METHODS

The effects of an aqueous extract of A. squamosa leaves on blood glucose, insulin, C-peptide, albumin, albumin/globulin ratio, urea, uric acid and creatinine and the activities of diagnostic marker enzymes aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase were examined in the plasma, liver and kidney tissues of control and experimental groups.

RESULTS

Oral administration of A. squamosa (300 mg/kg) aqueous extract to diabetic rats for 30 days significantly reduced blood glucose, urea, uric acid and creatinine, but increased the activities of insulin, C-peptide, albumin, albumin/globulin ratio and restored all marker enzymes to near control levels.

CONCLUSION

The present results shown that A. squamosa extract has an antihyperglycaemic effect and consequently may alleviate liver and renal damage associated with STZ-induced diabetes mellitus in rats.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18946614

Citation

Kaleem, M, et al. "Beneficial Effects of Annona Squamosa Extract in Streptozotocin-induced Diabetic Rats." Singapore Medical Journal, vol. 49, no. 10, 2008, pp. 800-4.
Kaleem M, Medha P, Ahmed QU, et al. Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J. 2008;49(10):800-4.
Kaleem, M., Medha, P., Ahmed, Q. U., Asif, M., & Bano, B. (2008). Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Medical Journal, 49(10), 800-4.
Kaleem M, et al. Beneficial Effects of Annona Squamosa Extract in Streptozotocin-induced Diabetic Rats. Singapore Med J. 2008;49(10):800-4. PubMed PMID: 18946614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats. AU - Kaleem,M, AU - Medha,P, AU - Ahmed,Q U, AU - Asif,M, AU - Bano,B, PY - 2008/10/24/pubmed PY - 2009/7/16/medline PY - 2008/10/24/entrez SP - 800 EP - 4 JF - Singapore medical journal JO - Singapore Med J VL - 49 IS - 10 N2 - INTRODUCTION: The present study investigated the possible therapeutic effects of Annona squamosa (A. squamosa) extract on certain biochemical markers in streptozotocin (STZ)-induced diabetes mellitus in rats. METHODS: The effects of an aqueous extract of A. squamosa leaves on blood glucose, insulin, C-peptide, albumin, albumin/globulin ratio, urea, uric acid and creatinine and the activities of diagnostic marker enzymes aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase were examined in the plasma, liver and kidney tissues of control and experimental groups. RESULTS: Oral administration of A. squamosa (300 mg/kg) aqueous extract to diabetic rats for 30 days significantly reduced blood glucose, urea, uric acid and creatinine, but increased the activities of insulin, C-peptide, albumin, albumin/globulin ratio and restored all marker enzymes to near control levels. CONCLUSION: The present results shown that A. squamosa extract has an antihyperglycaemic effect and consequently may alleviate liver and renal damage associated with STZ-induced diabetes mellitus in rats. SN - 0037-5675 UR - https://www.unboundmedicine.com/medline/citation/18946614/Beneficial_effects_of_Annona_squamosa_extract_in_streptozotocin_induced_diabetic_rats_ L2 - http://smj.sma.org.sg/4910/4910a7.pdf DB - PRIME DP - Unbound Medicine ER -