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Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome.
Atherosclerosis 2009; 204(2):521-5A

Abstract

OBJECTIVE

Controversy exists as to whether the association between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis is independent of other metabolic disorders. We examined the association between NAFLD and carotid intima-media thickness (IMT) according to the presence of metabolic syndrome (MetS).

METHODS

A cross-sectional analysis was performed among 556 men and 465 women, ages 30-79 years. The presence of NAFLD was evaluated ultrasonographically. Carotid IMT was determined ultrasonographically by the average of the maximal IMT at each common carotid artery. Independent associations between NAFLD and IMT were assessed using multiple linear and logistic regression models, after adjusting for age, sex, waist circumference, systolic blood pressure, fasting glucose, total/HDL-cholesterol ratio, smoking, and alcohol consumption.

RESULTS

After adjusting for major risk factors, subjects with NAFLD had greater carotid IMT than subjects without NAFLD (difference 0.034 mm, p=0.016). However, the difference in IMT was significant only in subjects with MetS (0.060 mm, p=0.015) and not in subjects without MetS (0.015 mm, p=0.384). Similarly, the NAFLD-associated adjusted odds ratio for increased IMT, defined as the sex-specific top quintile, was 1.63 (95% CI, 1.10-2.42) in all subjects and 2.08 (95% CI, 1.19-3.66) in subjects with MetS, but 1.18 (95% CI, 0.64-2.19) in subjects without MetS. When the analysis was performed according to the number of metabolic abnormalities, the NAFLD-IMT association was observed only in subjects with four or more abnormalities.

CONCLUSION

These results suggest that NAFLD is independently associated with carotid atherosclerosis only in people who have multiple metabolic abnormalities.

Authors+Show Affiliations

Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18947828

Citation

Kim, Hyeon Chang, et al. "Association Between Nonalcoholic Fatty Liver Disease and Carotid Intima-media Thickness According to the Presence of Metabolic Syndrome." Atherosclerosis, vol. 204, no. 2, 2009, pp. 521-5.
Kim HC, Kim DJ, Huh KB. Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome. Atherosclerosis. 2009;204(2):521-5.
Kim, H. C., Kim, D. J., & Huh, K. B. (2009). Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome. Atherosclerosis, 204(2), pp. 521-5. doi:10.1016/j.atherosclerosis.2008.09.012.
Kim HC, Kim DJ, Huh KB. Association Between Nonalcoholic Fatty Liver Disease and Carotid Intima-media Thickness According to the Presence of Metabolic Syndrome. Atherosclerosis. 2009;204(2):521-5. PubMed PMID: 18947828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome. AU - Kim,Hyeon Chang, AU - Kim,Dae Jung, AU - Huh,Kap Bum, Y1 - 2008/09/19/ PY - 2008/07/10/received PY - 2008/09/08/revised PY - 2008/09/09/accepted PY - 2008/10/25/pubmed PY - 2009/8/11/medline PY - 2008/10/25/entrez SP - 521 EP - 5 JF - Atherosclerosis JO - Atherosclerosis VL - 204 IS - 2 N2 - OBJECTIVE: Controversy exists as to whether the association between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis is independent of other metabolic disorders. We examined the association between NAFLD and carotid intima-media thickness (IMT) according to the presence of metabolic syndrome (MetS). METHODS: A cross-sectional analysis was performed among 556 men and 465 women, ages 30-79 years. The presence of NAFLD was evaluated ultrasonographically. Carotid IMT was determined ultrasonographically by the average of the maximal IMT at each common carotid artery. Independent associations between NAFLD and IMT were assessed using multiple linear and logistic regression models, after adjusting for age, sex, waist circumference, systolic blood pressure, fasting glucose, total/HDL-cholesterol ratio, smoking, and alcohol consumption. RESULTS: After adjusting for major risk factors, subjects with NAFLD had greater carotid IMT than subjects without NAFLD (difference 0.034 mm, p=0.016). However, the difference in IMT was significant only in subjects with MetS (0.060 mm, p=0.015) and not in subjects without MetS (0.015 mm, p=0.384). Similarly, the NAFLD-associated adjusted odds ratio for increased IMT, defined as the sex-specific top quintile, was 1.63 (95% CI, 1.10-2.42) in all subjects and 2.08 (95% CI, 1.19-3.66) in subjects with MetS, but 1.18 (95% CI, 0.64-2.19) in subjects without MetS. When the analysis was performed according to the number of metabolic abnormalities, the NAFLD-IMT association was observed only in subjects with four or more abnormalities. CONCLUSION: These results suggest that NAFLD is independently associated with carotid atherosclerosis only in people who have multiple metabolic abnormalities. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/18947828/Association_between_nonalcoholic_fatty_liver_disease_and_carotid_intima_media_thickness_according_to_the_presence_of_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(08)00632-1 DB - PRIME DP - Unbound Medicine ER -