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Red cell and endothelial Lu/BCAM beyond sickle cell disease.
Transfus Clin Biol. 2008 Dec; 15(6):402-5.TC

Abstract

Recent studies shed new lights on the biological function of blood group antigens, such as the adhesion properties of the Lutheran (Lu) blood group antigens carried by the Lu/BCAM glycoproteins. The Lu/BCAM adhesion glycoproteins were first identified as laminin-10/11 erythroid receptors involved in RBC adhesion to endothelium in sickle cell anemia. Lu/BCAM mediated cell adhesion to laminin is stimulated by epinephrine, a physiological stress mediator, and is dependent of phosphorylation by protein kinase A. More recently, we demonstrated that constitutive phosphorylation of Lu/BCAM is also involved in abnormal RBC adhesion to endothelium in patients with polycythemia vera (PV), a frequent myeloproliferative disorders associated with the V617F mutation of the tyrosine kinase JAK2 leading to continuous stimulation of erythropoiesis. This observation suggests that Lu/BCAM could participate to the high incidence of vascular thrombosis that also characterizes PV disease. In mice, which do not express Lu/BCAM in erytroid tissues, invalidation of the Lu/BCAM gene provided evidence that Lu/BCAM gps, as laminin-alpha5 receptors, are involved in vivo in the maintenance of normal basement membrane organization in different non erythroid tissues since up to 90% of the mutant kidney glomeruli exhibited a reduced number of visible capillary lumens and irregular thickening of the glomerular basement membrane, while intestine exhibited smooth muscle coat thickening and disorganization. All these results further illustrate that minor blood group antigens might have important role under physiological and physiopathological conditions in erythroid and non erythroid tissues as well.

Authors+Show Affiliations

Inserm UMR_S 665, Institut national de la transfusion sanguine, 6, rue Alexandre-Cabanel, 75015 Paris, France. yvescolin@inserm.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18948049

Citation

Colin, Y, et al. "Red Cell and Endothelial Lu/BCAM Beyond Sickle Cell Disease." Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine, vol. 15, no. 6, 2008, pp. 402-5.
Colin Y, Rahuel C, Wautier MP, et al. Red cell and endothelial Lu/BCAM beyond sickle cell disease. Transfus Clin Biol. 2008;15(6):402-5.
Colin, Y., Rahuel, C., Wautier, M. P., El Nemer, W., Filipe, A., Cartron, J. P., Le Van Kim, C., & Wautier, J. L. (2008). Red cell and endothelial Lu/BCAM beyond sickle cell disease. Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine, 15(6), 402-5. https://doi.org/10.1016/j.tracli.2008.07.011
Colin Y, et al. Red Cell and Endothelial Lu/BCAM Beyond Sickle Cell Disease. Transfus Clin Biol. 2008;15(6):402-5. PubMed PMID: 18948049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red cell and endothelial Lu/BCAM beyond sickle cell disease. AU - Colin,Y, AU - Rahuel,C, AU - Wautier,M-P, AU - El Nemer,W, AU - Filipe,A, AU - Cartron,J-P, AU - Le Van Kim,C, AU - Wautier,J-L, Y1 - 2008/10/22/ PY - 2008/06/27/received PY - 2008/07/30/accepted PY - 2008/10/25/pubmed PY - 2009/2/27/medline PY - 2008/10/25/entrez SP - 402 EP - 5 JF - Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine JO - Transfus Clin Biol VL - 15 IS - 6 N2 - Recent studies shed new lights on the biological function of blood group antigens, such as the adhesion properties of the Lutheran (Lu) blood group antigens carried by the Lu/BCAM glycoproteins. The Lu/BCAM adhesion glycoproteins were first identified as laminin-10/11 erythroid receptors involved in RBC adhesion to endothelium in sickle cell anemia. Lu/BCAM mediated cell adhesion to laminin is stimulated by epinephrine, a physiological stress mediator, and is dependent of phosphorylation by protein kinase A. More recently, we demonstrated that constitutive phosphorylation of Lu/BCAM is also involved in abnormal RBC adhesion to endothelium in patients with polycythemia vera (PV), a frequent myeloproliferative disorders associated with the V617F mutation of the tyrosine kinase JAK2 leading to continuous stimulation of erythropoiesis. This observation suggests that Lu/BCAM could participate to the high incidence of vascular thrombosis that also characterizes PV disease. In mice, which do not express Lu/BCAM in erytroid tissues, invalidation of the Lu/BCAM gene provided evidence that Lu/BCAM gps, as laminin-alpha5 receptors, are involved in vivo in the maintenance of normal basement membrane organization in different non erythroid tissues since up to 90% of the mutant kidney glomeruli exhibited a reduced number of visible capillary lumens and irregular thickening of the glomerular basement membrane, while intestine exhibited smooth muscle coat thickening and disorganization. All these results further illustrate that minor blood group antigens might have important role under physiological and physiopathological conditions in erythroid and non erythroid tissues as well. SN - 1246-7820 UR - https://www.unboundmedicine.com/medline/citation/18948049/Red_cell_and_endothelial_Lu/BCAM_beyond_sickle_cell_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1246-7820(08)00167-5 DB - PRIME DP - Unbound Medicine ER -