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[Small intestine bacterial overgrowth in patients with chronic pancreatitis].
Rev Med Chil 2008; 136(8):976-80RM

Abstract

BACKGROUND

Previous reports describe 30-40% of small intestine bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP), SIBO is a cause of persistent symptoms in this group of patients even when they are treated with pancreatic enzymes.

AIM

To asses the frequency of SIBO in patients with CP.

PATIENTS AND METHODS

We studied 14 patients with CP using an hydrogen breath test with lactulose to detect SIBO, a nonabsorbable carbohydrate, whose results are not influenced by the presence of exocrine insufficiency. Main symptoms and signs were bloating in 9 (64%), recurrent abdominal pain in 8 (57%), intermittent diarrhea in 5 (36%) and steatorrhea in 5 (36%). At the same time we studied a healthy control group paired by age and sex.

RESULTS

SIBO was present in 13 of 14 patients with CP (92%) and in 1 of 14 controls (p<0.001). The only patient with CP and without SIBO was recently diagnosed and had minimal morphologic alterations in computed tomography and endoscopic pancreatography.

CONCLUSIONS

SIBO is common in CP and may be responsible for persistent symptoms. Proper diagnosis and treatment could alleviate symptoms and improve quality of Ufe.

Authors+Show Affiliations

Sección de Gastroenterología, Hospital Clínico Universidad de Chile, Santiago, Chile.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

18949180

Citation

Mancilla A, Carla, et al. "[Small Intestine Bacterial Overgrowth in Patients With Chronic Pancreatitis]." Revista Medica De Chile, vol. 136, no. 8, 2008, pp. 976-80.
Mancilla A C, Madrid S AM, Hurtado H C, et al. [Small intestine bacterial overgrowth in patients with chronic pancreatitis]. Rev Med Chil. 2008;136(8):976-80.
Mancilla A, C., Madrid S, A. M., Hurtado H, C., Orellana B, C., Peña Z, M., Tobar A, E., & Berger F, Z. (2008). [Small intestine bacterial overgrowth in patients with chronic pancreatitis]. Revista Medica De Chile, 136(8), pp. 976-80. doi:/S0034-98872008000800003.
Mancilla A C, et al. [Small Intestine Bacterial Overgrowth in Patients With Chronic Pancreatitis]. Rev Med Chil. 2008;136(8):976-80. PubMed PMID: 18949180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Small intestine bacterial overgrowth in patients with chronic pancreatitis]. AU - Mancilla A,Carla, AU - Madrid S,Ana María, AU - Hurtado H,Carmen, AU - Orellana B,Carolina, AU - Peña Z,Margarita, AU - Tobar A,Eduardo, AU - Berger F,Zoltán, Y1 - 2008/10/07/ PY - 2008/10/25/pubmed PY - 2009/7/25/medline PY - 2008/10/25/entrez SP - 976 EP - 80 JF - Revista medica de Chile JO - Rev Med Chil VL - 136 IS - 8 N2 - BACKGROUND: Previous reports describe 30-40% of small intestine bacterial overgrowth (SIBO) in patients with chronic pancreatitis (CP), SIBO is a cause of persistent symptoms in this group of patients even when they are treated with pancreatic enzymes. AIM: To asses the frequency of SIBO in patients with CP. PATIENTS AND METHODS: We studied 14 patients with CP using an hydrogen breath test with lactulose to detect SIBO, a nonabsorbable carbohydrate, whose results are not influenced by the presence of exocrine insufficiency. Main symptoms and signs were bloating in 9 (64%), recurrent abdominal pain in 8 (57%), intermittent diarrhea in 5 (36%) and steatorrhea in 5 (36%). At the same time we studied a healthy control group paired by age and sex. RESULTS: SIBO was present in 13 of 14 patients with CP (92%) and in 1 of 14 controls (p<0.001). The only patient with CP and without SIBO was recently diagnosed and had minimal morphologic alterations in computed tomography and endoscopic pancreatography. CONCLUSIONS: SIBO is common in CP and may be responsible for persistent symptoms. Proper diagnosis and treatment could alleviate symptoms and improve quality of Ufe. SN - 0034-9887 UR - https://www.unboundmedicine.com/medline/citation/18949180/[Small_intestine_bacterial_overgrowth_in_patients_with_chronic_pancreatitis]_ L2 - http://www.scielo.cl/scielo.php?script=sci_arttext&amp;pid=S0034-98872008000800003&amp;lng=en&amp;nrm=iso&amp;tlng=en DB - PRIME DP - Unbound Medicine ER -