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Plasma levels of sex hormone-binding globulin, corticosteroid-binding globulin and cortisol in overweight subjects who develop impaired fasting glucose: a 3-year prospective study.
Horm Metab Res. 2009 Mar; 41(3):255-9.HM

Abstract

Circulating sex hormone-binding globulin (SHBG), corticosteroid-binding globulin (CBG), and total and calculated free cortisol were measured in 206 overweight subjects to investigate whether or not they were markers of insulin resistance. Measurements were carried out on two occasions 36 months apart and subjects were grouped according to fasting plasma glucose. Fifty-one subjects, with a normal basal fasting glucose (<5.6 mmol/l) developed impaired fasting glucose 3 years later (> or = 5.6 mmol/l). Analysis either in toto or based on gender showed a highly significant increase in fasting insulin and insulin resistance, a modest increase in body mass index (BMI), but importantly no change in plasma SHBG, CBG, or cortisol concentrations. Subjects (n=101) with a normal fasting glucose both at baseline (<5.6 mmol/l) and at 36 months showed no significant change in fasting insulin, insulin resistance, SHBG, CBG, cortisol, or BMI. Cross-sectional analysis of the study population showed that plasma SHBG correlated negatively with insulin resistance both in men and women. Overall SHBG at baseline was not predictive of changes in fasting glucose. In females, plasma CBG correlated negatively with BMI. The major finding is that overweight subjects who developed impaired fasting glucose showed no significant change in plasma SHBG, CBG or cortisol, and therefore these indices are probably not early markers of insulin resistance in overweight subjects.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lewis JG
Steroid and Immunobiochemistry Laboratory, Canterbury Health Laboratories, Christchurch, New Zealand. john.lewis@cdhb.govt.nz
Shand BI
No affiliation info available
Frampton CM
No affiliation info available
Elder PA
No affiliation info available
Scott RS
No affiliation info available

MeSH

Blood GlucoseBody Mass IndexFastingFemaleFollow-Up StudiesGlucose IntoleranceHumansHydrocortisoneInsulinMaleOverweightProspective StudiesSex Hormone-Binding GlobulinTime FactorsTranscortin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18949680

Citation

Lewis, J G., et al. "Plasma Levels of Sex Hormone-binding Globulin, Corticosteroid-binding Globulin and Cortisol in Overweight Subjects Who Develop Impaired Fasting Glucose: a 3-year Prospective Study." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 41, no. 3, 2009, pp. 255-9.
Lewis JG, Shand BI, Frampton CM, et al. Plasma levels of sex hormone-binding globulin, corticosteroid-binding globulin and cortisol in overweight subjects who develop impaired fasting glucose: a 3-year prospective study. Horm Metab Res. 2009;41(3):255-9.
Lewis, J. G., Shand, B. I., Frampton, C. M., Elder, P. A., & Scott, R. S. (2009). Plasma levels of sex hormone-binding globulin, corticosteroid-binding globulin and cortisol in overweight subjects who develop impaired fasting glucose: a 3-year prospective study. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 41(3), 255-9. https://doi.org/10.1055/s-0028-1087190
Lewis JG, et al. Plasma Levels of Sex Hormone-binding Globulin, Corticosteroid-binding Globulin and Cortisol in Overweight Subjects Who Develop Impaired Fasting Glucose: a 3-year Prospective Study. Horm Metab Res. 2009;41(3):255-9. PubMed PMID: 18949680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma levels of sex hormone-binding globulin, corticosteroid-binding globulin and cortisol in overweight subjects who develop impaired fasting glucose: a 3-year prospective study. AU - Lewis,J G, AU - Shand,B I, AU - Frampton,C M, AU - Elder,P A, AU - Scott,R S, Y1 - 2008/10/23/ PY - 2008/10/25/pubmed PY - 2009/5/21/medline PY - 2008/10/25/entrez SP - 255 EP - 9 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 41 IS - 3 N2 - Circulating sex hormone-binding globulin (SHBG), corticosteroid-binding globulin (CBG), and total and calculated free cortisol were measured in 206 overweight subjects to investigate whether or not they were markers of insulin resistance. Measurements were carried out on two occasions 36 months apart and subjects were grouped according to fasting plasma glucose. Fifty-one subjects, with a normal basal fasting glucose (<5.6 mmol/l) developed impaired fasting glucose 3 years later (> or = 5.6 mmol/l). Analysis either in toto or based on gender showed a highly significant increase in fasting insulin and insulin resistance, a modest increase in body mass index (BMI), but importantly no change in plasma SHBG, CBG, or cortisol concentrations. Subjects (n=101) with a normal fasting glucose both at baseline (<5.6 mmol/l) and at 36 months showed no significant change in fasting insulin, insulin resistance, SHBG, CBG, cortisol, or BMI. Cross-sectional analysis of the study population showed that plasma SHBG correlated negatively with insulin resistance both in men and women. Overall SHBG at baseline was not predictive of changes in fasting glucose. In females, plasma CBG correlated negatively with BMI. The major finding is that overweight subjects who developed impaired fasting glucose showed no significant change in plasma SHBG, CBG or cortisol, and therefore these indices are probably not early markers of insulin resistance in overweight subjects. SN - 1439-4286 UR - https://www.unboundmedicine.com/medline/citation/18949680/Plasma_levels_of_sex_hormone_binding_globulin_corticosteroid_binding_globulin_and_cortisol_in_overweight_subjects_who_develop_impaired_fasting_glucose:_a_3_year_prospective_study_ DB - PRIME DP - Unbound Medicine ER -