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Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes.
Food Chem Toxicol. 2009 Jan; 47(1):50-4.FC

Abstract

The present study investigated the effects of Punica granatum aqueous extract (PgAq) on streptozotocin (STZ) induced diabetic rats by measuring fasting blood glucose, lipid profiles (atherogenic index), lipid peroxidation (LPO) and activities of both non-enzymatic and enzymatic antioxidants. Diabetes was induced by single intraperitoneal injection of STZ (60 mg/kg) to albino Wistar rats. The increase in blood glucose level, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), very low density lipoprotein (VLDL), LPO level with decrease in high density lipoprotein cholesterol (HDL-C), reduced glutathione (GSH) content and antioxidant enzymes namely, glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) were the salient features observed in diabetic rats. On the other hand, oral administration of PgAq at doses of 250 mg/kg and 500 mg/kg for 21 days resulted in a significant reduction in fasting blood glucose, TC, TG, LDL-C, VLDL-C and tissue LPO levels coupled with elevation of HDL-C, GSH content and antioxidant enzymes in comparison with diabetic control group. The results suggest that PG could be used, as a dietary supplement, in the treatment of chronic diseases characterized by atherogenous lipoprotein profile, aggravated antioxidant status and impaired glucose metabolism and also in their prevention.

Authors+Show Affiliations

Department of Pharmacognosy and Phytochemistry, Pharmacognosy and Pharmaceutical Research Laboratory, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18950673

Citation

Bagri, Priyanka, et al. "Antidiabetic Effect of Punica Granatum Flowers: Effect On Hyperlipidemia, Pancreatic Cells Lipid Peroxidation and Antioxidant Enzymes in Experimental Diabetes." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 1, 2009, pp. 50-4.
Bagri P, Ali M, Aeri V, et al. Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem Toxicol. 2009;47(1):50-4.
Bagri, P., Ali, M., Aeri, V., Bhowmik, M., & Sultana, S. (2009). Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(1), 50-4. https://doi.org/10.1016/j.fct.2008.09.058
Bagri P, et al. Antidiabetic Effect of Punica Granatum Flowers: Effect On Hyperlipidemia, Pancreatic Cells Lipid Peroxidation and Antioxidant Enzymes in Experimental Diabetes. Food Chem Toxicol. 2009;47(1):50-4. PubMed PMID: 18950673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. AU - Bagri,Priyanka, AU - Ali,Mohd, AU - Aeri,Vidhu, AU - Bhowmik,Malay, AU - Sultana,Shahnaz, Y1 - 2008/10/04/ PY - 2007/10/13/received PY - 2008/09/09/revised PY - 2008/09/27/accepted PY - 2008/10/28/entrez PY - 2008/10/28/pubmed PY - 2009/3/17/medline SP - 50 EP - 4 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 1 N2 - The present study investigated the effects of Punica granatum aqueous extract (PgAq) on streptozotocin (STZ) induced diabetic rats by measuring fasting blood glucose, lipid profiles (atherogenic index), lipid peroxidation (LPO) and activities of both non-enzymatic and enzymatic antioxidants. Diabetes was induced by single intraperitoneal injection of STZ (60 mg/kg) to albino Wistar rats. The increase in blood glucose level, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), very low density lipoprotein (VLDL), LPO level with decrease in high density lipoprotein cholesterol (HDL-C), reduced glutathione (GSH) content and antioxidant enzymes namely, glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) were the salient features observed in diabetic rats. On the other hand, oral administration of PgAq at doses of 250 mg/kg and 500 mg/kg for 21 days resulted in a significant reduction in fasting blood glucose, TC, TG, LDL-C, VLDL-C and tissue LPO levels coupled with elevation of HDL-C, GSH content and antioxidant enzymes in comparison with diabetic control group. The results suggest that PG could be used, as a dietary supplement, in the treatment of chronic diseases characterized by atherogenous lipoprotein profile, aggravated antioxidant status and impaired glucose metabolism and also in their prevention. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/18950673/Antidiabetic_effect_of_Punica_granatum_flowers:_effect_on_hyperlipidemia_pancreatic_cells_lipid_peroxidation_and_antioxidant_enzymes_in_experimental_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00555-3 DB - PRIME DP - Unbound Medicine ER -