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Gait analysis in multiple sclerosis: characterization of temporal-spatial parameters using GAITRite functional ambulation system.
Gait Posture. 2009 Jan; 29(1):138-42.GP

Abstract

BACKGROUND

Gait impairment is a significant problem in multiple sclerosis (MS), leading to decreased activity and limitations in function. However, specific characterization of abnormal gait in MS patients has only been described in small groups of patients, mainly using observational tools.

OBJECTIVE

The aim of the current study was to characterize the spatio-temporal gait parameters in MS patients and ascribe them to clinical variables, in order to enable target-oriented management.

METHODS

Eighty-one MS patients with relatively short disease duration (5.3; S.E.=0.3) able of independent walking and 25 age-matched healthy subjects were evaluated using the GAITRite Functional Ambulation System. Subjects also underwent a thorough neurological examination to assess their disability using the Expanded Disability Status Scale (EDSS). Gait parameters were compared between patients and able-bodied controls to characterize the gait impairments in MS. Within the group of patients the correlation of gait parameters with clinical neurological variables was investigated.

RESULTS

MS patients demonstrated significant impairments in all spatio-temporal gait parameters compared to able-bodied healthy subjects. MS patients had a mean Functional Ambulation Profile (FAP) score of 83.0 and a mean velocity of 85.5m/s while the controls had a FAP score of 95.0 (p<0.001) and a velocity of 138.6m/s (p<0.001). Cadence was 94.4 steps/min in MS patients and 115.2 in controls (p<0.001). Step length was 45.3 cm in MS patients and 72.1 cm in controls (p<0.001). FAP score negatively correlated with disease duration (p<0.001) and EDSS (p<0.001). The most significant correlations of the FAP were found with the pyramidal (p<0.002), and the cerebellar (p<0.05) functional scores. Specifically, gait velocity, single support time and swing time negatively correlated with the pyramidal functional score, while double support time positively correlated with the pyramidal score. The base support width positively correlated with cerebellar functional score.

CONCLUSIONS

Gait parameters were impaired in MS, even in patients with relatively short disease duration. The impaired gait patterns correlated with the associated neurological disability. Specific and accurate assessment of gait can be a useful tool to monitor MS evolution and can be used to advise target-oriented rehabilitative management of MS patients.

Authors+Show Affiliations

Department of Pediatric Orthopaedics, Safra Hospital for Children and Motion Analysis Laboratory, Sheba Medical Center, Tel-Hashomer, Israel. ugivon@zahav.net.ilNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18951800

Citation

Givon, Uri, et al. "Gait Analysis in Multiple Sclerosis: Characterization of Temporal-spatial Parameters Using GAITRite Functional Ambulation System." Gait & Posture, vol. 29, no. 1, 2009, pp. 138-42.
Givon U, Zeilig G, Achiron A. Gait analysis in multiple sclerosis: characterization of temporal-spatial parameters using GAITRite functional ambulation system. Gait Posture. 2009;29(1):138-42.
Givon, U., Zeilig, G., & Achiron, A. (2009). Gait analysis in multiple sclerosis: characterization of temporal-spatial parameters using GAITRite functional ambulation system. Gait & Posture, 29(1), 138-42. https://doi.org/10.1016/j.gaitpost.2008.07.011
Givon U, Zeilig G, Achiron A. Gait Analysis in Multiple Sclerosis: Characterization of Temporal-spatial Parameters Using GAITRite Functional Ambulation System. Gait Posture. 2009;29(1):138-42. PubMed PMID: 18951800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gait analysis in multiple sclerosis: characterization of temporal-spatial parameters using GAITRite functional ambulation system. AU - Givon,Uri, AU - Zeilig,Gabriel, AU - Achiron,Anat, Y1 - 2008/10/31/ PY - 2007/05/11/received PY - 2008/07/23/revised PY - 2008/07/24/accepted PY - 2008/10/28/pubmed PY - 2009/3/4/medline PY - 2008/10/28/entrez SP - 138 EP - 42 JF - Gait & posture JO - Gait Posture VL - 29 IS - 1 N2 - BACKGROUND: Gait impairment is a significant problem in multiple sclerosis (MS), leading to decreased activity and limitations in function. However, specific characterization of abnormal gait in MS patients has only been described in small groups of patients, mainly using observational tools. OBJECTIVE: The aim of the current study was to characterize the spatio-temporal gait parameters in MS patients and ascribe them to clinical variables, in order to enable target-oriented management. METHODS: Eighty-one MS patients with relatively short disease duration (5.3; S.E.=0.3) able of independent walking and 25 age-matched healthy subjects were evaluated using the GAITRite Functional Ambulation System. Subjects also underwent a thorough neurological examination to assess their disability using the Expanded Disability Status Scale (EDSS). Gait parameters were compared between patients and able-bodied controls to characterize the gait impairments in MS. Within the group of patients the correlation of gait parameters with clinical neurological variables was investigated. RESULTS: MS patients demonstrated significant impairments in all spatio-temporal gait parameters compared to able-bodied healthy subjects. MS patients had a mean Functional Ambulation Profile (FAP) score of 83.0 and a mean velocity of 85.5m/s while the controls had a FAP score of 95.0 (p<0.001) and a velocity of 138.6m/s (p<0.001). Cadence was 94.4 steps/min in MS patients and 115.2 in controls (p<0.001). Step length was 45.3 cm in MS patients and 72.1 cm in controls (p<0.001). FAP score negatively correlated with disease duration (p<0.001) and EDSS (p<0.001). The most significant correlations of the FAP were found with the pyramidal (p<0.002), and the cerebellar (p<0.05) functional scores. Specifically, gait velocity, single support time and swing time negatively correlated with the pyramidal functional score, while double support time positively correlated with the pyramidal score. The base support width positively correlated with cerebellar functional score. CONCLUSIONS: Gait parameters were impaired in MS, even in patients with relatively short disease duration. The impaired gait patterns correlated with the associated neurological disability. Specific and accurate assessment of gait can be a useful tool to monitor MS evolution and can be used to advise target-oriented rehabilitative management of MS patients. SN - 0966-6362 UR - https://www.unboundmedicine.com/medline/citation/18951800/Gait_analysis_in_multiple_sclerosis:_characterization_of_temporal_spatial_parameters_using_GAITRite_functional_ambulation_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0966-6362(08)00209-9 DB - PRIME DP - Unbound Medicine ER -