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Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men.
Atherosclerosis. 2009 Jun; 204(2):e70-6.A

Abstract

BACKGROUND

Inflammation is crucial in all stages of atherosclerosis, and few studies have investigated the effect of dietary fat on markers of inflammation related to this disease during the postprandial period.

OBJECTIVE

To evaluate the chronic effects of dietary fat on the postprandial expression of proinflammatory genes in peripheral blood mononuclear cells (PBMCs) in healthy subjects.

DESIGN

20 healthy men followed three different diets for 4 weeks each, according to a randomized crossover design: Western diet: 15% protein, 47% carbohydrates (CHO), 38% fat (22% saturated fatty acid (SFA)); Mediterranean diet: 15% protein, 47% CHO, 38% fat (24% monounsaturated fatty acid (MUFA)); CHO-rich and n-3 diet: 15% protein, 55% CHO, <30% fat (8% polyunsaturated fatty acid (PUFA)). After 12-h fast, volunteers were given a breakfast with a fat composition similar to that consumed in each of the diets-butter breakfast: 35% SFA; olive oil breakfast: 36% MUFA; walnut breakfast: 16% PUFA, 4% alpha-linolenic acid (LNA).

RESULTS

The butter breakfast induced a higher increase in tumor necrosis factor (TNF)-alpha messenger RNA (mRNA) expression than the olive oil or walnut breakfasts (P=0.014) in PBMCs. Moreover, we found a higher postprandial response in the mRNA of interleukin (IL)-6 with the intake of butter and olive oil breakfasts than with the walnut breakfast (P=0.025) in these cells. However, the effects of the three fatty breakfasts on the plasma concentrations of these proinflammatory parameters showed no significant differences (P=N.S.).

CONCLUSION

Consumption of a butter-enriched meal elicits greater postprandial expression of proinflammatory cytokine mRNA in PBMCs, compared to the olive oil and walnut breakfasts.

Authors+Show Affiliations

The Lipids and Arteriosclerosis Unit, Reina Sofía University Hospital, University of Córdoba, CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Avenida Menéndez Pidal s/n, 14004 Córdoba, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18952211

Citation

Jiménez-Gómez, Yolanda, et al. "Olive Oil and Walnut Breakfasts Reduce the Postprandial Inflammatory Response in Mononuclear Cells Compared With a Butter Breakfast in Healthy Men." Atherosclerosis, vol. 204, no. 2, 2009, pp. e70-6.
Jiménez-Gómez Y, López-Miranda J, Blanco-Colio LM, et al. Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men. Atherosclerosis. 2009;204(2):e70-6.
Jiménez-Gómez, Y., López-Miranda, J., Blanco-Colio, L. M., Marín, C., Pérez-Martínez, P., Ruano, J., Paniagua, J. A., Rodríguez, F., Egido, J., & Pérez-Jiménez, F. (2009). Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men. Atherosclerosis, 204(2), e70-6. https://doi.org/10.1016/j.atherosclerosis.2008.09.011
Jiménez-Gómez Y, et al. Olive Oil and Walnut Breakfasts Reduce the Postprandial Inflammatory Response in Mononuclear Cells Compared With a Butter Breakfast in Healthy Men. Atherosclerosis. 2009;204(2):e70-6. PubMed PMID: 18952211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men. AU - Jiménez-Gómez,Yolanda, AU - López-Miranda,José, AU - Blanco-Colio,Luis M, AU - Marín,Carmen, AU - Pérez-Martínez,Pablo, AU - Ruano,Juan, AU - Paniagua,Juan A, AU - Rodríguez,Fernando, AU - Egido,Jesús, AU - Pérez-Jiménez,Francisco, Y1 - 2008/09/17/ PY - 2007/08/17/received PY - 2008/08/04/revised PY - 2008/09/09/accepted PY - 2008/10/28/pubmed PY - 2009/8/11/medline PY - 2008/10/28/entrez SP - e70 EP - 6 JF - Atherosclerosis JO - Atherosclerosis VL - 204 IS - 2 N2 - BACKGROUND: Inflammation is crucial in all stages of atherosclerosis, and few studies have investigated the effect of dietary fat on markers of inflammation related to this disease during the postprandial period. OBJECTIVE: To evaluate the chronic effects of dietary fat on the postprandial expression of proinflammatory genes in peripheral blood mononuclear cells (PBMCs) in healthy subjects. DESIGN: 20 healthy men followed three different diets for 4 weeks each, according to a randomized crossover design: Western diet: 15% protein, 47% carbohydrates (CHO), 38% fat (22% saturated fatty acid (SFA)); Mediterranean diet: 15% protein, 47% CHO, 38% fat (24% monounsaturated fatty acid (MUFA)); CHO-rich and n-3 diet: 15% protein, 55% CHO, <30% fat (8% polyunsaturated fatty acid (PUFA)). After 12-h fast, volunteers were given a breakfast with a fat composition similar to that consumed in each of the diets-butter breakfast: 35% SFA; olive oil breakfast: 36% MUFA; walnut breakfast: 16% PUFA, 4% alpha-linolenic acid (LNA). RESULTS: The butter breakfast induced a higher increase in tumor necrosis factor (TNF)-alpha messenger RNA (mRNA) expression than the olive oil or walnut breakfasts (P=0.014) in PBMCs. Moreover, we found a higher postprandial response in the mRNA of interleukin (IL)-6 with the intake of butter and olive oil breakfasts than with the walnut breakfast (P=0.025) in these cells. However, the effects of the three fatty breakfasts on the plasma concentrations of these proinflammatory parameters showed no significant differences (P=N.S.). CONCLUSION: Consumption of a butter-enriched meal elicits greater postprandial expression of proinflammatory cytokine mRNA in PBMCs, compared to the olive oil and walnut breakfasts. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/18952211/Olive_oil_and_walnut_breakfasts_reduce_the_postprandial_inflammatory_response_in_mononuclear_cells_compared_with_a_butter_breakfast_in_healthy_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(08)00628-X DB - PRIME DP - Unbound Medicine ER -