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Training induced decrease in oxygen cost of cycling is accompanied by down-regulation of SERCA expression in human vastus lateralis muscle.
J Physiol Pharmacol. 2008 Sep; 59(3):589-602.JP

Abstract

We have examined the effect of 5 week cycling endurance training program on the sarco(endo)plasmic reticulum Ca2+ ATPase isoforms (SERCA1 and 2) and myosin heavy chain (MyHC) in the vastus lateralis muscle as well as on the oxygen uptake to power output ratio (VO2/PO) during incremental cycling. Fifteen untrained men performed an incremental cycling exercise until exhaustion before and after moderate intensity training. Muscle biopsies were taken from vastus lateralis before and after training program. Training resulted in higher (P = 0.048) maximal oxygen uptake (VO(2max)) as well as in higher power output reached at VO(2max) (P = 0.0001). Moreover, lower (P = 0.02) VO2/PO ratio determined during incremental moderate intensity cycling (i.e. 30-120 W) as well as lower (P = 0.003) VO2/PO ratio reached at VO(2max) were observed after the training. A significant down regulation of SERCA2 protein (P = 0.03) and tendency (P = 0.055) to lower SERCA1 content accompanied by lower (P<10(-4)) plasma thyroid hormone concentration, with no changes (P = 0.67) in MyHC composition in vastus lateralis muscle were found after training. We have concluded that the increase in mechanical efficiency of cycling occurring during first weeks of endurance training is not related to changes in MyHC composition but it may be due to down-regulation of SERCA pumps.

Authors+Show Affiliations

Department of Physiology and Biochemistry, Faculty of Rehabilitation, University School of Physical Education, Krakow, Poland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18953100

Citation

Majerczak, J, et al. "Training Induced Decrease in Oxygen Cost of Cycling Is Accompanied By Down-regulation of SERCA Expression in Human Vastus Lateralis Muscle." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 59, no. 3, 2008, pp. 589-602.
Majerczak J, Karasinski J, Zoladz JA. Training induced decrease in oxygen cost of cycling is accompanied by down-regulation of SERCA expression in human vastus lateralis muscle. J Physiol Pharmacol. 2008;59(3):589-602.
Majerczak, J., Karasinski, J., & Zoladz, J. A. (2008). Training induced decrease in oxygen cost of cycling is accompanied by down-regulation of SERCA expression in human vastus lateralis muscle. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 59(3), 589-602.
Majerczak J, Karasinski J, Zoladz JA. Training Induced Decrease in Oxygen Cost of Cycling Is Accompanied By Down-regulation of SERCA Expression in Human Vastus Lateralis Muscle. J Physiol Pharmacol. 2008;59(3):589-602. PubMed PMID: 18953100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Training induced decrease in oxygen cost of cycling is accompanied by down-regulation of SERCA expression in human vastus lateralis muscle. AU - Majerczak,J, AU - Karasinski,J, AU - Zoladz,J A, PY - 2008/04/24/received PY - 2008/07/30/accepted PY - 2008/10/28/pubmed PY - 2009/1/31/medline PY - 2008/10/28/entrez SP - 589 EP - 602 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J. Physiol. Pharmacol. VL - 59 IS - 3 N2 - We have examined the effect of 5 week cycling endurance training program on the sarco(endo)plasmic reticulum Ca2+ ATPase isoforms (SERCA1 and 2) and myosin heavy chain (MyHC) in the vastus lateralis muscle as well as on the oxygen uptake to power output ratio (VO2/PO) during incremental cycling. Fifteen untrained men performed an incremental cycling exercise until exhaustion before and after moderate intensity training. Muscle biopsies were taken from vastus lateralis before and after training program. Training resulted in higher (P = 0.048) maximal oxygen uptake (VO(2max)) as well as in higher power output reached at VO(2max) (P = 0.0001). Moreover, lower (P = 0.02) VO2/PO ratio determined during incremental moderate intensity cycling (i.e. 30-120 W) as well as lower (P = 0.003) VO2/PO ratio reached at VO(2max) were observed after the training. A significant down regulation of SERCA2 protein (P = 0.03) and tendency (P = 0.055) to lower SERCA1 content accompanied by lower (P<10(-4)) plasma thyroid hormone concentration, with no changes (P = 0.67) in MyHC composition in vastus lateralis muscle were found after training. We have concluded that the increase in mechanical efficiency of cycling occurring during first weeks of endurance training is not related to changes in MyHC composition but it may be due to down-regulation of SERCA pumps. SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/18953100/Training_induced_decrease_in_oxygen_cost_of_cycling_is_accompanied_by_down_regulation_of_SERCA_expression_in_human_vastus_lateralis_muscle_ L2 - http://www.jpp.krakow.pl/journal/archive/09_08/pdf/589_09_08_article.pdf DB - PRIME DP - Unbound Medicine ER -