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Patent foramen ovale: clinical manifestations and treatment.
Rev Cardiovasc Med 2008; 9(3):168-73RC

Abstract

A persistent patent foramen ovale produces an intermittent intra-atrial right-to-left shunt and occurs in approximately 25% of the general population. Although the vast majority of people with patent foramen ovale are asymptomatic, a patent foramen ovale is believed to act as a pathway for chemicals or thrombus that can result in a variety of clinical manifestations, including stroke, migraine headache, decompression sickness, high-altitude pulmonary edema, and platypnea-orthodeoxia syndrome. The optimal management of patients with patent foramen ovale who experience cryptogenic stroke is unclear. Percutaneous closure appears to have a low risk profile and has been considered in high-risk patients who are not candidates for randomized clinical trials. Randomized clinical trials that are underway should help define the best management of patent foramen ovale, as well as the true safety and efficacy of percutaneous closure devices.

Authors+Show Affiliations

Division of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18953276

Citation

Kedia, Gautam, et al. "Patent Foramen Ovale: Clinical Manifestations and Treatment." Reviews in Cardiovascular Medicine, vol. 9, no. 3, 2008, pp. 168-73.
Kedia G, Tobis J, Lee MS. Patent foramen ovale: clinical manifestations and treatment. Rev Cardiovasc Med. 2008;9(3):168-73.
Kedia, G., Tobis, J., & Lee, M. S. (2008). Patent foramen ovale: clinical manifestations and treatment. Reviews in Cardiovascular Medicine, 9(3), pp. 168-73.
Kedia G, Tobis J, Lee MS. Patent Foramen Ovale: Clinical Manifestations and Treatment. Rev Cardiovasc Med. 2008;9(3):168-73. PubMed PMID: 18953276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patent foramen ovale: clinical manifestations and treatment. AU - Kedia,Gautam, AU - Tobis,Jonathan, AU - Lee,Michael S, PY - 2008/10/28/pubmed PY - 2008/11/14/medline PY - 2008/10/28/entrez SP - 168 EP - 73 JF - Reviews in cardiovascular medicine JO - Rev Cardiovasc Med VL - 9 IS - 3 N2 - A persistent patent foramen ovale produces an intermittent intra-atrial right-to-left shunt and occurs in approximately 25% of the general population. Although the vast majority of people with patent foramen ovale are asymptomatic, a patent foramen ovale is believed to act as a pathway for chemicals or thrombus that can result in a variety of clinical manifestations, including stroke, migraine headache, decompression sickness, high-altitude pulmonary edema, and platypnea-orthodeoxia syndrome. The optimal management of patients with patent foramen ovale who experience cryptogenic stroke is unclear. Percutaneous closure appears to have a low risk profile and has been considered in high-risk patients who are not candidates for randomized clinical trials. Randomized clinical trials that are underway should help define the best management of patent foramen ovale, as well as the true safety and efficacy of percutaneous closure devices. SN - 1530-6550 UR - https://www.unboundmedicine.com/medline/citation/18953276/Patent_foramen_ovale:_clinical_manifestations_and_treatment_ L2 - http://www.diseaseinfosearch.org/result/9666 DB - PRIME DP - Unbound Medicine ER -