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[Neuropsychiatric problems in patients with Parkinson's disease].
Zhonghua Yi Xue Za Zhi. 2008 Jun 03; 88(21):1442-5.ZY

Abstract

OBJECTIVE

To survey the prevalence and distribution of neuropsychiatric problems in patients with Parkinson's disease (PD), and to investigate their effects on life quality and the interactions among different neuropsychiatric problems.

METHODS

Unified Parkinson's disease rating scale (UPDRS) part III, dyskinesia and motor fluctuation subscale of UPDRS part IV, mini-mental state examination (MMSE) ,Montreal Cognitive Assessment (MoCA), Hamilton rate scale of depression (HRSD), Hamilton anxiety scale (HAMA), digit span (DS), and 39 item Parkinson's disease questionnaire (PDQ-39) were used to assess the motor symptoms and neuropsychiatric problems in 116 PD patients, 66 males and 50 females, aged (67 +/- 9) (50-90), with the course of disease of 5 +/- 4 years (0.5--18 years). Spearman rank order correlation and hierarchical regressions of the major statistical procedures were employed.

RESULTS

Various neuropsychiatric problems were found in the PD patients. The neuropsychiatric problems, such as depression, anxiety, apathy, attention deficit disorder, and cognitive deficits, were correlated with the UPDRS III score and Hoehn-Yahr stage, but not correlated with the course of disease (all P > 0.05). Hallucination was not correlated with any factors (all P > 0.05). There were some correlations among different neuropsychiatric problems. Hierarchical regression revealed that different neuropsychiatric problems showed significant effects on the quality of life after controlling the motor symptoms. Depression (deltaR2 = 19.1%, P < 0.01) and apathy (deltaR2 = 17.0%, P < 0.01) exerted the most powerful influence in causing poor quality of life.

CONCLUSION

Neuropsychiatric problems are common a in PD patients Their effects on the poor quality of life are no less than that of motor symptoms and should be recognized and treated well.

Authors+Show Affiliations

Department of Neurology, Xinhua Hospital of Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18953846

Citation

Zhou, Ming-zhu, et al. "[Neuropsychiatric Problems in Patients With Parkinson's Disease]." Zhonghua Yi Xue Za Zhi, vol. 88, no. 21, 2008, pp. 1442-5.
Zhou MZ, Liu ZG, Gan J, et al. [Neuropsychiatric problems in patients with Parkinson's disease]. Zhonghua Yi Xue Za Zhi. 2008;88(21):1442-5.
Zhou, M. Z., Liu, Z. G., Gan, J., Chen, W., Lu, L. X., & Wu, J. Y. (2008). [Neuropsychiatric problems in patients with Parkinson's disease]. Zhonghua Yi Xue Za Zhi, 88(21), 1442-5.
Zhou MZ, et al. [Neuropsychiatric Problems in Patients With Parkinson's Disease]. Zhonghua Yi Xue Za Zhi. 2008 Jun 3;88(21):1442-5. PubMed PMID: 18953846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Neuropsychiatric problems in patients with Parkinson's disease]. AU - Zhou,Ming-zhu, AU - Liu,Zhen-guo, AU - Gan,Jing, AU - Chen,Wei, AU - Lu,Li-xia, AU - Wu,Jia-ying, PY - 2008/10/29/pubmed PY - 2009/4/10/medline PY - 2008/10/29/entrez SP - 1442 EP - 5 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 88 IS - 21 N2 - OBJECTIVE: To survey the prevalence and distribution of neuropsychiatric problems in patients with Parkinson's disease (PD), and to investigate their effects on life quality and the interactions among different neuropsychiatric problems. METHODS: Unified Parkinson's disease rating scale (UPDRS) part III, dyskinesia and motor fluctuation subscale of UPDRS part IV, mini-mental state examination (MMSE) ,Montreal Cognitive Assessment (MoCA), Hamilton rate scale of depression (HRSD), Hamilton anxiety scale (HAMA), digit span (DS), and 39 item Parkinson's disease questionnaire (PDQ-39) were used to assess the motor symptoms and neuropsychiatric problems in 116 PD patients, 66 males and 50 females, aged (67 +/- 9) (50-90), with the course of disease of 5 +/- 4 years (0.5--18 years). Spearman rank order correlation and hierarchical regressions of the major statistical procedures were employed. RESULTS: Various neuropsychiatric problems were found in the PD patients. The neuropsychiatric problems, such as depression, anxiety, apathy, attention deficit disorder, and cognitive deficits, were correlated with the UPDRS III score and Hoehn-Yahr stage, but not correlated with the course of disease (all P > 0.05). Hallucination was not correlated with any factors (all P > 0.05). There were some correlations among different neuropsychiatric problems. Hierarchical regression revealed that different neuropsychiatric problems showed significant effects on the quality of life after controlling the motor symptoms. Depression (deltaR2 = 19.1%, P < 0.01) and apathy (deltaR2 = 17.0%, P < 0.01) exerted the most powerful influence in causing poor quality of life. CONCLUSION: Neuropsychiatric problems are common a in PD patients Their effects on the poor quality of life are no less than that of motor symptoms and should be recognized and treated well. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/18953846/[Neuropsychiatric_problems_in_patients_with_Parkinson's_disease]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2008&amp;vol=88&amp;issue=21&amp;fpage=1442 DB - PRIME DP - Unbound Medicine ER -