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In vitro release and characterization of chitosan films as dexamethasone carrier.
Int J Pharm. 2009 Feb 23; 368(1-2):1-6.IJ

Abstract

Chitosan, a biodegradable and biocompatible polysaccharide, is a potentially useful material in various fields. We produced mono and bilayer chitosan films containing dexamethasone as a drug carrier for controlled release. The chitosan drug-loaded films were produced by a casting/solvent evaporation technique using 2 wt% acetic acid solution and distilled water and they were dried at room temperature. These films were characterized by release and swelling studies, DSC and ATR-FTIR. The total profile for water absorption was similar for the types of films developed. ATR-FTIR analysis showed little change in the band position of the O--H and N--H stretching from dexamethasone and chitosan, respectively. DSC analysis from bilayer film indicates that the dexamethasone peak was shifted from 256 to 240 degrees C. These results suggested an interaction between hydroxyl and amino groups of chitosan and hydroxyl groups of dexamethasone. In the drug release studies it was observed 89.6% release from the monolayer film in 8h and 84% from the bilayer film in 4 weeks. These results suggested that the chitosan sheet prepared in this study is a promising delivery carrier for dexamethasone.

Authors+Show Affiliations

Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Pampulha, Belo Horizonte (MG) 31270-901, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18955123

Citation

Rodrigues, Lívia B., et al. "In Vitro Release and Characterization of Chitosan Films as Dexamethasone Carrier." International Journal of Pharmaceutics, vol. 368, no. 1-2, 2009, pp. 1-6.
Rodrigues LB, Leite HF, Yoshida MI, et al. In vitro release and characterization of chitosan films as dexamethasone carrier. Int J Pharm. 2009;368(1-2):1-6.
Rodrigues, L. B., Leite, H. F., Yoshida, M. I., Saliba, J. B., Cunha, A. S., & Faraco, A. A. (2009). In vitro release and characterization of chitosan films as dexamethasone carrier. International Journal of Pharmaceutics, 368(1-2), 1-6. https://doi.org/10.1016/j.ijpharm.2008.09.047
Rodrigues LB, et al. In Vitro Release and Characterization of Chitosan Films as Dexamethasone Carrier. Int J Pharm. 2009 Feb 23;368(1-2):1-6. PubMed PMID: 18955123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro release and characterization of chitosan films as dexamethasone carrier. AU - Rodrigues,Lívia B, AU - Leite,Helena F, AU - Yoshida,Maria I, AU - Saliba,Juliana B, AU - Cunha,Armando S,Jr AU - Faraco,André A G, Y1 - 2008/10/07/ PY - 2008/07/25/received PY - 2008/09/24/accepted PY - 2008/10/29/pubmed PY - 2009/7/16/medline PY - 2008/10/29/entrez SP - 1 EP - 6 JF - International journal of pharmaceutics JO - Int J Pharm VL - 368 IS - 1-2 N2 - Chitosan, a biodegradable and biocompatible polysaccharide, is a potentially useful material in various fields. We produced mono and bilayer chitosan films containing dexamethasone as a drug carrier for controlled release. The chitosan drug-loaded films were produced by a casting/solvent evaporation technique using 2 wt% acetic acid solution and distilled water and they were dried at room temperature. These films were characterized by release and swelling studies, DSC and ATR-FTIR. The total profile for water absorption was similar for the types of films developed. ATR-FTIR analysis showed little change in the band position of the O--H and N--H stretching from dexamethasone and chitosan, respectively. DSC analysis from bilayer film indicates that the dexamethasone peak was shifted from 256 to 240 degrees C. These results suggested an interaction between hydroxyl and amino groups of chitosan and hydroxyl groups of dexamethasone. In the drug release studies it was observed 89.6% release from the monolayer film in 8h and 84% from the bilayer film in 4 weeks. These results suggested that the chitosan sheet prepared in this study is a promising delivery carrier for dexamethasone. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/18955123/In_vitro_release_and_characterization_of_chitosan_films_as_dexamethasone_carrier_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(08)00678-9 DB - PRIME DP - Unbound Medicine ER -