Tags

Type your tag names separated by a space and hit enter

Low frequency and variability of FLT3 mutations in Korean patients with acute myeloid leukemia.
J Korean Med Sci. 2008 Oct; 23(5):833-7.JK

Abstract

FLT3 mutations are common genetic changes, and are reported to have prognostic significance in acute myeloid leukemia (AML). The FLT3 internal tandem duplication (ITD) and the D835 activating mutation in the tyrosine kinase domain (TKD) were analyzed by polymerase chain reaction (PCR) in the genomic DNA of Korean patients with AML at diagnosis and during follow-up. There were 226 patients with AML enrolled between March 1996 and August 2005. The incidence of ITD and TKD at diagnosis was 13% (29/226) and 3% (6/226). When compared to Western and other Asian patients with AML, Korean patients had a lower frequency by about two-thirds of ITD and TKD. Among the non-M3 cases (N=203), the patients with an ITD had a significantly shorter event-free survival when compared with those without an ITD (p=0.0079). Among 54 relapsed patients, 9 patients had the FLT3 ITD at diagnosis. Six patients demonstrated a reappearance of the ITD and 3 patients remained negative at relapse. One patient, among 45 patients who relapsed, had a negative baseline ITD but acquired a de novo ITD at relapse. There were 101 samples from 93 patients in remission; they were all negative for an ITD. Among 34 patients who failed to achieve a remission, five patients had a persistent ITD and one patient had a de novo ITD. These results support the concept of resistance of FLT3 ITD leukemic clones to chemotherapy. Therefore, effective therapy with FLT3 targeting agents may improve the prognosis of non-M3 AML patients with the FLT3 mutation.

Links

PMC Free PDF
PMC Free Full Text
FREE Publisher Full Text

Authors+Show Affiliations

Bang SM
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Ahn JY
No affiliation info available
Park J
No affiliation info available
Park SH
No affiliation info available
Park J
No affiliation info available
Cho EK
No affiliation info available
Shin DB
No affiliation info available
Lee JH
No affiliation info available
Yoo SJ
No affiliation info available
Jeon IS
No affiliation info available
Kim YK
No affiliation info available
Kim HJ
No affiliation info available
Kim HN
No affiliation info available
Lee IK
No affiliation info available
Kang HJ
No affiliation info available
Shin HY
No affiliation info available
Ahn HS
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overChildChild, PreschoolDisease-Free SurvivalFemaleGene Expression Regulation, NeoplasticHumansInfantInfant, NewbornKoreaLeukemia, Myeloid, AcuteMaleMiddle AgedMutationPrognosisRecurrenceRemission Inductionfms-Like Tyrosine Kinase 3

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18955790

Citation

Bang, Soo-Mee, et al. "Low Frequency and Variability of FLT3 Mutations in Korean Patients With Acute Myeloid Leukemia." Journal of Korean Medical Science, vol. 23, no. 5, 2008, pp. 833-7.
Bang SM, Ahn JY, Park J, et al. Low frequency and variability of FLT3 mutations in Korean patients with acute myeloid leukemia. J Korean Med Sci. 2008;23(5):833-7.
Bang, S. M., Ahn, J. Y., Park, J., Park, S. H., Park, J., Cho, E. K., Shin, D. B., Lee, J. H., Yoo, S. J., Jeon, I. S., Kim, Y. K., Kim, H. J., Kim, H. N., Lee, I. K., Kang, H. J., Shin, H. Y., & Ahn, H. S. (2008). Low frequency and variability of FLT3 mutations in Korean patients with acute myeloid leukemia. Journal of Korean Medical Science, 23(5), 833-7. https://doi.org/10.3346/jkms.2008.23.5.833
Bang SM, et al. Low Frequency and Variability of FLT3 Mutations in Korean Patients With Acute Myeloid Leukemia. J Korean Med Sci. 2008;23(5):833-7. PubMed PMID: 18955790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low frequency and variability of FLT3 mutations in Korean patients with acute myeloid leukemia. AU - Bang,Soo-Mee, AU - Ahn,Jeong Yeal, AU - Park,Jiyoon, AU - Park,Se Hoon, AU - Park,Jinny, AU - Cho,Eun Kyung, AU - Shin,Dong Bok, AU - Lee,Jae Hoon, AU - Yoo,Soo Jin, AU - Jeon,In Sang, AU - Kim,Yeo-Kyeoung, AU - Kim,Hyeoung Joon, AU - Kim,Hee-Nam, AU - Lee,Il-Kwon, AU - Kang,Hyoung Jin, AU - Shin,Hee Young, AU - Ahn,Hyo Seop, PY - 2008/10/29/pubmed PY - 2008/12/19/medline PY - 2008/10/29/entrez SP - 833 EP - 7 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 23 IS - 5 N2 - FLT3 mutations are common genetic changes, and are reported to have prognostic significance in acute myeloid leukemia (AML). The FLT3 internal tandem duplication (ITD) and the D835 activating mutation in the tyrosine kinase domain (TKD) were analyzed by polymerase chain reaction (PCR) in the genomic DNA of Korean patients with AML at diagnosis and during follow-up. There were 226 patients with AML enrolled between March 1996 and August 2005. The incidence of ITD and TKD at diagnosis was 13% (29/226) and 3% (6/226). When compared to Western and other Asian patients with AML, Korean patients had a lower frequency by about two-thirds of ITD and TKD. Among the non-M3 cases (N=203), the patients with an ITD had a significantly shorter event-free survival when compared with those without an ITD (p=0.0079). Among 54 relapsed patients, 9 patients had the FLT3 ITD at diagnosis. Six patients demonstrated a reappearance of the ITD and 3 patients remained negative at relapse. One patient, among 45 patients who relapsed, had a negative baseline ITD but acquired a de novo ITD at relapse. There were 101 samples from 93 patients in remission; they were all negative for an ITD. Among 34 patients who failed to achieve a remission, five patients had a persistent ITD and one patient had a de novo ITD. These results support the concept of resistance of FLT3 ITD leukemic clones to chemotherapy. Therefore, effective therapy with FLT3 targeting agents may improve the prognosis of non-M3 AML patients with the FLT3 mutation. SN - 1011-8934 UR - https://www.unboundmedicine.com/medline/citation/18955790/Low_frequency_and_variability_of_FLT3_mutations_in_Korean_patients_with_acute_myeloid_leukemia_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2008.23.5.833 DB - PRIME DP - Unbound Medicine ER -