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Human uncoupling protein 2 and 3 genes are associated with obesity in Japanese.
Endocrine 2008 Aug-Dec; 34(1-3):87-95E

Abstract

Human uncoupling proteins (UCPs) are mitochondrial proteins that are involved in the control of energy metabolism and the pathophysiology of obesity. Although there have been several reports on the association between the UCP2/UCP3 locus and the obesity, there have been no haplotype-based case-control studies with gender-specific analysis. The aim of this study was to examine whether there is an association between the UCP2/UCP3 locus and the obesity in the Japanese population when using a single nucleotide polymorphism (SNP)-based and haplotype-based case-control study with gender-specific analysis. We examined a group consisting of 551 subjects, of which 369 were non-obese and 182 were overweight and/or obese. We selected one nonsynonymous SNP (rs660339: Ala55Val) as a genetic marker. Genotyping for all subjects was performed by the TaqMan polymerase chain reaction (PCR) method. Although the overall distributions of genotype and allele were not significantly different between the non-obese and the obese groups, the overall distributions of the genotype were significantly different in men (P = 0.030). In the obese group, male subjects with the Val allele were significantly more frequent in both association studies. There was a significant difference in the overall distribution of the haplotype (UCP3 rs180049, UCP3 rs2075577, UCP2 rs660339) between the weight groups (P = 0.010), and in women, there was a significant difference (P = 0.042) in the overall distribution of the haplotype (UCP3 rs2075577, UCP2 rs660339). Nonsynonymous rs660339 in the human UCP2 gene in men, and the haplotype (UCP3 rs2075577-UCP2 rs660339) in women might be good obesity markers.

Authors+Show Affiliations

Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18956255

Citation

Kosuge, Kotoko, et al. "Human Uncoupling Protein 2 and 3 Genes Are Associated With Obesity in Japanese." Endocrine, vol. 34, no. 1-3, 2008, pp. 87-95.
Kosuge K, Soma M, Nakayama T, et al. Human uncoupling protein 2 and 3 genes are associated with obesity in Japanese. Endocrine. 2008;34(1-3):87-95.
Kosuge, K., Soma, M., Nakayama, T., Aoi, N., Sato, M., Haketa, A., ... Matsumoto, K. (2008). Human uncoupling protein 2 and 3 genes are associated with obesity in Japanese. Endocrine, 34(1-3), pp. 87-95. doi:10.1007/s12020-008-9111-9.
Kosuge K, et al. Human Uncoupling Protein 2 and 3 Genes Are Associated With Obesity in Japanese. Endocrine. 2008;34(1-3):87-95. PubMed PMID: 18956255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human uncoupling protein 2 and 3 genes are associated with obesity in Japanese. AU - Kosuge,Kotoko, AU - Soma,Masayoshi, AU - Nakayama,Tomohiro, AU - Aoi,Noriko, AU - Sato,Mikano, AU - Haketa,Akira, AU - Uwabo,Jiro, AU - Izumi,Yoichi, AU - Matsumoto,Koichi, Y1 - 2008/10/28/ PY - 2008/07/18/received PY - 2008/08/29/accepted PY - 2008/08/18/revised PY - 2008/10/29/pubmed PY - 2009/5/5/medline PY - 2008/10/29/entrez SP - 87 EP - 95 JF - Endocrine JO - Endocrine VL - 34 IS - 1-3 N2 - Human uncoupling proteins (UCPs) are mitochondrial proteins that are involved in the control of energy metabolism and the pathophysiology of obesity. Although there have been several reports on the association between the UCP2/UCP3 locus and the obesity, there have been no haplotype-based case-control studies with gender-specific analysis. The aim of this study was to examine whether there is an association between the UCP2/UCP3 locus and the obesity in the Japanese population when using a single nucleotide polymorphism (SNP)-based and haplotype-based case-control study with gender-specific analysis. We examined a group consisting of 551 subjects, of which 369 were non-obese and 182 were overweight and/or obese. We selected one nonsynonymous SNP (rs660339: Ala55Val) as a genetic marker. Genotyping for all subjects was performed by the TaqMan polymerase chain reaction (PCR) method. Although the overall distributions of genotype and allele were not significantly different between the non-obese and the obese groups, the overall distributions of the genotype were significantly different in men (P = 0.030). In the obese group, male subjects with the Val allele were significantly more frequent in both association studies. There was a significant difference in the overall distribution of the haplotype (UCP3 rs180049, UCP3 rs2075577, UCP2 rs660339) between the weight groups (P = 0.010), and in women, there was a significant difference (P = 0.042) in the overall distribution of the haplotype (UCP3 rs2075577, UCP2 rs660339). Nonsynonymous rs660339 in the human UCP2 gene in men, and the haplotype (UCP3 rs2075577-UCP2 rs660339) in women might be good obesity markers. SN - 1355-008X UR - https://www.unboundmedicine.com/medline/citation/18956255/Human_uncoupling_protein_2_and_3_genes_are_associated_with_obesity_in_Japanese_ L2 - https://dx.doi.org/10.1007/s12020-008-9111-9 DB - PRIME DP - Unbound Medicine ER -