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The impact of benzodiazepine use on methadone maintenance treatment outcomes.
J Addict Dis. 2008; 27(3):37-48.JA

Abstract

The purposes of this study were to examine predictors of benzodiazepine use among methadone maintenance treatment patients, to determine whether baseline benzodiazepine use influenced ongoing use during methadone maintenance treatment, and to assess the effect of ongoing benzodiazepine use on treatment outcomes (i.e., opioid and cocaine use and treatment retention). A retrospective chart review of 172 methadone maintenance treatment patients (mean age = 34.6 years; standard deviation = 8.5 years; 64% male) from January 1997 to December 1999 was conducted. At baseline, 29% were "non-users" (past year) of benzodiazepine, 36% were "occasional users," and 35% were "regular/problem users." Regular/problem users were more likely to have started opioid use with prescription opioids, experienced more overdoses, and reported psychiatric comorbidity. Being female, more years of opioid use, and a history of psychiatric treatment were significant predictors of baseline benzodiazepine use. Ongoing benzodiazepine users were more likely to have opioid-positive and cocaine-positive urine screens during methadone maintenance treatment. Only ongoing cocaine use was negatively related to retention. Benzodiazepine use by methadone maintenance treatment patients is associated with a more complex clinical picture and may negatively influence treatment outcomes.

Authors+Show Affiliations

Centre for Addiction and Mental Health, Toronto, Canada. bruna_brands@hc-sc.gc.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18956528

Citation

Brands, Bruna, et al. "The Impact of Benzodiazepine Use On Methadone Maintenance Treatment Outcomes." Journal of Addictive Diseases, vol. 27, no. 3, 2008, pp. 37-48.
Brands B, Blake J, Marsh DC, et al. The impact of benzodiazepine use on methadone maintenance treatment outcomes. J Addict Dis. 2008;27(3):37-48.
Brands, B., Blake, J., Marsh, D. C., Sproule, B., Jeyapalan, R., & Li, S. (2008). The impact of benzodiazepine use on methadone maintenance treatment outcomes. Journal of Addictive Diseases, 27(3), 37-48. https://doi.org/10.1080/10550880802122620
Brands B, et al. The Impact of Benzodiazepine Use On Methadone Maintenance Treatment Outcomes. J Addict Dis. 2008;27(3):37-48. PubMed PMID: 18956528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of benzodiazepine use on methadone maintenance treatment outcomes. AU - Brands,Bruna, AU - Blake,Joan, AU - Marsh,David C, AU - Sproule,Beth, AU - Jeyapalan,Renuka, AU - Li,Selina, PY - 2008/10/30/pubmed PY - 2008/12/17/medline PY - 2008/10/30/entrez SP - 37 EP - 48 JF - Journal of addictive diseases JO - J Addict Dis VL - 27 IS - 3 N2 - The purposes of this study were to examine predictors of benzodiazepine use among methadone maintenance treatment patients, to determine whether baseline benzodiazepine use influenced ongoing use during methadone maintenance treatment, and to assess the effect of ongoing benzodiazepine use on treatment outcomes (i.e., opioid and cocaine use and treatment retention). A retrospective chart review of 172 methadone maintenance treatment patients (mean age = 34.6 years; standard deviation = 8.5 years; 64% male) from January 1997 to December 1999 was conducted. At baseline, 29% were "non-users" (past year) of benzodiazepine, 36% were "occasional users," and 35% were "regular/problem users." Regular/problem users were more likely to have started opioid use with prescription opioids, experienced more overdoses, and reported psychiatric comorbidity. Being female, more years of opioid use, and a history of psychiatric treatment were significant predictors of baseline benzodiazepine use. Ongoing benzodiazepine users were more likely to have opioid-positive and cocaine-positive urine screens during methadone maintenance treatment. Only ongoing cocaine use was negatively related to retention. Benzodiazepine use by methadone maintenance treatment patients is associated with a more complex clinical picture and may negatively influence treatment outcomes. SN - 1055-0887 UR - https://www.unboundmedicine.com/medline/citation/18956528/The_impact_of_benzodiazepine_use_on_methadone_maintenance_treatment_outcomes_ L2 - https://www.tandfonline.com/doi/full/10.1080/10550880802122620 DB - PRIME DP - Unbound Medicine ER -