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[Main flavonoids from Sophora flavescenes].
Yao Xue Xue Bao. 2008 Aug; 43(8):833-7.YX

Abstract

Radix Sophorae Flavescentis is a traditional Chinese medicine, which is the roots of Sophora flavescens and is used to treat abscess, dysentery, eczema and skin itch. The main active compounds of the roots of Sophora flavescens are alkaloids and flavonoids. To provide reference compounds for HPLC-DAD qualitification analysis of flavanonoids and for study on the bioactivities of flavanonoids, six main flavanonoids were isolated from the roots of Sophora flavescens. They are 5-methoxy-7, 2', 4'-trihydroxy-8-[3,3-dimethylallyl] -flavanone (1), isoxanthohumol (2), 3/beta, 7, 4'-trihydroxy-5-methoxy-8-[3,3-dimethylallyl] -flavanone (3), nor-kurarinone [(2S) -sophoraflavanone G] (4), kurarinone (5) and kushenol I (6). Compound 1 is a new compound, and compound 3 is obtained from Sophora flavecens for the first time. The 13C NMR data of compounds 3 and 5 are reported for the first time.

Authors+Show Affiliations

Department of Natural Medicines and State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18956776

Citation

Li, Wei, et al. "[Main Flavonoids From Sophora Flavescenes]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 43, no. 8, 2008, pp. 833-7.
Li W, Liang H, Yin T, et al. [Main flavonoids from Sophora flavescenes]. Yao Xue Xue Bao. 2008;43(8):833-7.
Li, W., Liang, H., Yin, T., Wang, B., & Zhao, Y. Y. (2008). [Main flavonoids from Sophora flavescenes]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 43(8), 833-7.
Li W, et al. [Main Flavonoids From Sophora Flavescenes]. Yao Xue Xue Bao. 2008;43(8):833-7. PubMed PMID: 18956776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Main flavonoids from Sophora flavescenes]. AU - Li,Wei, AU - Liang,Hong, AU - Yin,Ting, AU - Wang,Bin, AU - Zhao,Yu-Ying, PY - 2008/10/30/pubmed PY - 2009/9/18/medline PY - 2008/10/30/entrez SP - 833 EP - 7 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 43 IS - 8 N2 - Radix Sophorae Flavescentis is a traditional Chinese medicine, which is the roots of Sophora flavescens and is used to treat abscess, dysentery, eczema and skin itch. The main active compounds of the roots of Sophora flavescens are alkaloids and flavonoids. To provide reference compounds for HPLC-DAD qualitification analysis of flavanonoids and for study on the bioactivities of flavanonoids, six main flavanonoids were isolated from the roots of Sophora flavescens. They are 5-methoxy-7, 2', 4'-trihydroxy-8-[3,3-dimethylallyl] -flavanone (1), isoxanthohumol (2), 3/beta, 7, 4'-trihydroxy-5-methoxy-8-[3,3-dimethylallyl] -flavanone (3), nor-kurarinone [(2S) -sophoraflavanone G] (4), kurarinone (5) and kushenol I (6). Compound 1 is a new compound, and compound 3 is obtained from Sophora flavecens for the first time. The 13C NMR data of compounds 3 and 5 are reported for the first time. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/18956776/[Main_flavonoids_from_Sophora_flavescenes]_ L2 - https://antibodies.cancer.gov/detail/CPTC-ITCH-1 DB - PRIME DP - Unbound Medicine ER -