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Differential endocannabinoid regulation of extinction in appetitive and aversive Barnes maze tasks.
Learn Mem. 2008 Nov; 15(11):806-9.LM

Abstract

CB 1 receptor-compromised animals show profound deficits in extinguishing learned behavior from aversive conditioning tasks, but display normal extinction learning in appetitive operant tasks. However, it is difficult to discern whether the differential involvement of the endogenous cannabinoid system on extinction results from the hedonics or the required responses associated with the disparate tasks. Here, we report that the CB 1 receptor antagonist rimonabant disrupts extinction learning in an aversive, but not in an appetitive, Barnes maze conditioning task. Accordingly, these results provide compelling support for the hypothesis that the endogenous cannabinoid system plays a necessary role in the extinction of aversively motivated behaviors but is expendable for appetitively motivated behaviors.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23284, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18957525

Citation

Harloe, John P., et al. "Differential Endocannabinoid Regulation of Extinction in Appetitive and Aversive Barnes Maze Tasks." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 15, no. 11, 2008, pp. 806-9.
Harloe JP, Thorpe AJ, Lichtman AH. Differential endocannabinoid regulation of extinction in appetitive and aversive Barnes maze tasks. Learn Mem. 2008;15(11):806-9.
Harloe, J. P., Thorpe, A. J., & Lichtman, A. H. (2008). Differential endocannabinoid regulation of extinction in appetitive and aversive Barnes maze tasks. Learning & Memory (Cold Spring Harbor, N.Y.), 15(11), 806-9. https://doi.org/10.1101/lm.1113008
Harloe JP, Thorpe AJ, Lichtman AH. Differential Endocannabinoid Regulation of Extinction in Appetitive and Aversive Barnes Maze Tasks. Learn Mem. 2008;15(11):806-9. PubMed PMID: 18957525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential endocannabinoid regulation of extinction in appetitive and aversive Barnes maze tasks. AU - Harloe,John P, AU - Thorpe,Andrew J, AU - Lichtman,Aron H, Y1 - 2008/10/28/ PY - 2008/10/30/pubmed PY - 2009/2/10/medline PY - 2008/10/30/entrez SP - 806 EP - 9 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn. Mem. VL - 15 IS - 11 N2 - CB 1 receptor-compromised animals show profound deficits in extinguishing learned behavior from aversive conditioning tasks, but display normal extinction learning in appetitive operant tasks. However, it is difficult to discern whether the differential involvement of the endogenous cannabinoid system on extinction results from the hedonics or the required responses associated with the disparate tasks. Here, we report that the CB 1 receptor antagonist rimonabant disrupts extinction learning in an aversive, but not in an appetitive, Barnes maze conditioning task. Accordingly, these results provide compelling support for the hypothesis that the endogenous cannabinoid system plays a necessary role in the extinction of aversively motivated behaviors but is expendable for appetitively motivated behaviors. SN - 1549-5485 UR - https://www.unboundmedicine.com/medline/citation/18957525/Differential_endocannabinoid_regulation_of_extinction_in_appetitive_and_aversive_Barnes_maze_tasks_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18957525/ DB - PRIME DP - Unbound Medicine ER -