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Prevalence and determinants of prehypertension in a Japanese general population: the Jichi Medical School Cohort Study.
Hypertens Res 2008; 31(7):1323-30HR

Abstract

It has been reported that subjects with prehypertension (pre-HT) (systolic blood pressure [SBP] 120-139 mmHg and/or diastolic blood pressure [DBP] 80-89 mmHg) have an increased risk of cardiovascular disease (CVD). We evaluated the prevalence and determinants of pre-HT in a Japanese general population. We enrolled 4,706 males and 7,342 females aged 18 to 90 years whose BPs were measured at baseline. The subjects' BPs were classified as follows: normotension (NT: SPB/DBP < 120/80 mmHg), pre-HT (120/80-139/89 mmHg), and hypertension (HT: > or = 140/90 mmHg or treated hypertension). The prevalence of pre-HT was 34.8% (males), and 31.8% (females). Body mass index (BMI) of more than 23.0 kg/m2 was the strongest determinant of pre-HT (Males--BMI: 23.0-24.9 kg/m2, odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.21-1.79; BMI: 25.0-26.9 kg/m2, OR = 2.20, 95% CI =1.68-2.87; BMI: 27.0-29.9 kg/m2, OR = 2.75, 95% CI = 1.80-4.19; BMI: > or = 30.0 kg/m2, OR = 3.39, 95% CI = 1.21-9.46. Females--BMI: 23.0-24.9 kg/m2, OR = 1.67, 95% CI = 1.42-1.95; BMI: 25.0-26.9 kg/m2, OR = 1.79, 95% CI = 1.46-2.19; BMI: 27.0-29.9 kg/m2, OR = 3.65, 95% CI = 2.73-4.89; BMI: > or = 30.0 kg/m2, OR = 4.23, 95% CI = 2.33-7.70). The other determinants of pre-HT were hyperlipidemia (Males: OR = 1.25; Females: OR = 1.43), and aging (by 10 years; Males: OR = 1.12; Females: OR = 1.48). Determinants of pre-HT in females were impaired glucose tolerance (OR = 1.41, 95% CI = 1.03-1.94), diabetes (OR = 2.01, 95% CI = 1.16-3.47) and a family history of HT in both parents (OR = 1.90, 95% CI = 1.38-2.62), whereas in males the only other predictor was alcohol drinking (OR = 1.45, 95% CI = 1.23-1.70). In conclusion, even subjects with a mild increase of BMI (23.0-24.9 kg/m2) had an increased risk of pre-HT in a Japanese population, and the level of BMI associated with pre-HT was lower than that in Western countries. Additionally, there were gender differences in the determinants of pre-HT.

Authors+Show Affiliations

Division of Community and Family Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18957802

Citation

Ishikawa, Yukiko, et al. "Prevalence and Determinants of Prehypertension in a Japanese General Population: the Jichi Medical School Cohort Study." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 31, no. 7, 2008, pp. 1323-30.
Ishikawa Y, Ishikawa J, Ishikawa S, et al. Prevalence and determinants of prehypertension in a Japanese general population: the Jichi Medical School Cohort Study. Hypertens Res. 2008;31(7):1323-30.
Ishikawa, Y., Ishikawa, J., Ishikawa, S., Kayaba, K., Nakamura, Y., Shimada, K., ... Kario, K. (2008). Prevalence and determinants of prehypertension in a Japanese general population: the Jichi Medical School Cohort Study. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 31(7), pp. 1323-30. doi:10.1291/hypres.31.1323.
Ishikawa Y, et al. Prevalence and Determinants of Prehypertension in a Japanese General Population: the Jichi Medical School Cohort Study. Hypertens Res. 2008;31(7):1323-30. PubMed PMID: 18957802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and determinants of prehypertension in a Japanese general population: the Jichi Medical School Cohort Study. AU - Ishikawa,Yukiko, AU - Ishikawa,Joji, AU - Ishikawa,Shizukiyo, AU - Kayaba,Kazunori, AU - Nakamura,Yosikazu, AU - Shimada,Kazuyuki, AU - Kajii,Eiji, AU - Pickering,Thomas G, AU - Kario,Kazuomi, AU - ,, PY - 2008/10/30/pubmed PY - 2008/11/14/medline PY - 2008/10/30/entrez SP - 1323 EP - 30 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens. Res. VL - 31 IS - 7 N2 - It has been reported that subjects with prehypertension (pre-HT) (systolic blood pressure [SBP] 120-139 mmHg and/or diastolic blood pressure [DBP] 80-89 mmHg) have an increased risk of cardiovascular disease (CVD). We evaluated the prevalence and determinants of pre-HT in a Japanese general population. We enrolled 4,706 males and 7,342 females aged 18 to 90 years whose BPs were measured at baseline. The subjects' BPs were classified as follows: normotension (NT: SPB/DBP < 120/80 mmHg), pre-HT (120/80-139/89 mmHg), and hypertension (HT: > or = 140/90 mmHg or treated hypertension). The prevalence of pre-HT was 34.8% (males), and 31.8% (females). Body mass index (BMI) of more than 23.0 kg/m2 was the strongest determinant of pre-HT (Males--BMI: 23.0-24.9 kg/m2, odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.21-1.79; BMI: 25.0-26.9 kg/m2, OR = 2.20, 95% CI =1.68-2.87; BMI: 27.0-29.9 kg/m2, OR = 2.75, 95% CI = 1.80-4.19; BMI: > or = 30.0 kg/m2, OR = 3.39, 95% CI = 1.21-9.46. Females--BMI: 23.0-24.9 kg/m2, OR = 1.67, 95% CI = 1.42-1.95; BMI: 25.0-26.9 kg/m2, OR = 1.79, 95% CI = 1.46-2.19; BMI: 27.0-29.9 kg/m2, OR = 3.65, 95% CI = 2.73-4.89; BMI: > or = 30.0 kg/m2, OR = 4.23, 95% CI = 2.33-7.70). The other determinants of pre-HT were hyperlipidemia (Males: OR = 1.25; Females: OR = 1.43), and aging (by 10 years; Males: OR = 1.12; Females: OR = 1.48). Determinants of pre-HT in females were impaired glucose tolerance (OR = 1.41, 95% CI = 1.03-1.94), diabetes (OR = 2.01, 95% CI = 1.16-3.47) and a family history of HT in both parents (OR = 1.90, 95% CI = 1.38-2.62), whereas in males the only other predictor was alcohol drinking (OR = 1.45, 95% CI = 1.23-1.70). In conclusion, even subjects with a mild increase of BMI (23.0-24.9 kg/m2) had an increased risk of pre-HT in a Japanese population, and the level of BMI associated with pre-HT was lower than that in Western countries. Additionally, there were gender differences in the determinants of pre-HT. SN - 0916-9636 UR - https://www.unboundmedicine.com/medline/citation/18957802/Prevalence_and_determinants_of_prehypertension_in_a_Japanese_general_population:_the_Jichi_Medical_School_Cohort_Study_ L2 - http://dx.doi.org/10.1291/hypres.31.1323 DB - PRIME DP - Unbound Medicine ER -