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Glucose oxidation and PQQ-dependent dehydrogenases in Gluconobacter oxydans.
J Mol Microbiol Biotechnol. 2009; 16(1-2):6-13.JM

Abstract

Gluconobacter oxydans is famous for its rapid and incomplete oxidation of a wide range of sugars and sugar alcohols. The organism is known for its efficient oxidation of D-glucose to D-gluconate, which can be further oxidized to two different keto-D-gluconates, 2-keto-D-gluconate and 5-keto-D-gluconate, as well as 2,5-di-keto-D-gluconate. For this oxidation chain and for further oxidation reactions, G. oxydans possesses a high number of membrane-bound dehydrogenases. In this review, we focus on the dehydrogenases involved in D-glucose oxidation and the products formed during this process. As some of the involved dehydrogenases contain pyrroloquinoline quinone (PQQ) as a cofactor, also PQQ synthesis is reviewed. Finally, we will give an overview of further PQQ-dependent dehydrogenases and discuss their functions in G. oxydans ATCC 621H (DSM 2343).

Authors+Show Affiliations

Fachgebiet Technische Biochemie, Institut fur Biotechnologie der Technischen Universität Berlin, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18957858

Citation

Hölscher, Tina, et al. "Glucose Oxidation and PQQ-dependent Dehydrogenases in Gluconobacter Oxydans." Journal of Molecular Microbiology and Biotechnology, vol. 16, no. 1-2, 2009, pp. 6-13.
Hölscher T, Schleyer U, Merfort M, et al. Glucose oxidation and PQQ-dependent dehydrogenases in Gluconobacter oxydans. J Mol Microbiol Biotechnol. 2009;16(1-2):6-13.
Hölscher, T., Schleyer, U., Merfort, M., Bringer-Meyer, S., Görisch, H., & Sahm, H. (2009). Glucose oxidation and PQQ-dependent dehydrogenases in Gluconobacter oxydans. Journal of Molecular Microbiology and Biotechnology, 16(1-2), 6-13. https://doi.org/10.1159/000142890
Hölscher T, et al. Glucose Oxidation and PQQ-dependent Dehydrogenases in Gluconobacter Oxydans. J Mol Microbiol Biotechnol. 2009;16(1-2):6-13. PubMed PMID: 18957858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucose oxidation and PQQ-dependent dehydrogenases in Gluconobacter oxydans. AU - Hölscher,Tina, AU - Schleyer,Ute, AU - Merfort,Marcel, AU - Bringer-Meyer,Stephanie, AU - Görisch,Helmut, AU - Sahm,Hermann, Y1 - 2008/10/29/ PY - 2008/10/30/pubmed PY - 2009/2/4/medline PY - 2008/10/30/entrez SP - 6 EP - 13 JF - Journal of molecular microbiology and biotechnology JO - J. Mol. Microbiol. Biotechnol. VL - 16 IS - 1-2 N2 - Gluconobacter oxydans is famous for its rapid and incomplete oxidation of a wide range of sugars and sugar alcohols. The organism is known for its efficient oxidation of D-glucose to D-gluconate, which can be further oxidized to two different keto-D-gluconates, 2-keto-D-gluconate and 5-keto-D-gluconate, as well as 2,5-di-keto-D-gluconate. For this oxidation chain and for further oxidation reactions, G. oxydans possesses a high number of membrane-bound dehydrogenases. In this review, we focus on the dehydrogenases involved in D-glucose oxidation and the products formed during this process. As some of the involved dehydrogenases contain pyrroloquinoline quinone (PQQ) as a cofactor, also PQQ synthesis is reviewed. Finally, we will give an overview of further PQQ-dependent dehydrogenases and discuss their functions in G. oxydans ATCC 621H (DSM 2343). SN - 1660-2412 UR - https://www.unboundmedicine.com/medline/citation/18957858/Glucose_oxidation_and_PQQ_dependent_dehydrogenases_in_Gluconobacter_oxydans_ L2 - https://www.karger.com?DOI=10.1159/000142890 DB - PRIME DP - Unbound Medicine ER -