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Effects of ubiquinone (coenzyme Q10) on myopathy in statin users.
Curr Opin Lipidol. 2008 Dec; 19(6):553-7.CO

Abstract

PURPOSE OF REVIEW

Statins are associated with muscle complaints, including myositis. The mechanism through which statin use causes muscle toxicity is unknown. One of the theories is that statin therapy reduces coenzyme Q10 levels in muscle mitochondria, which leads to muscle injury and myopathy. The aim of the present article is to review published data on the association between coenzyme Q10 and statin-associated myopathy.

RECENT FINDINGS

Studies have consistently shown that statins reduce coenzyme Q10 levels in serum and that supplementation of coenzyme Q10 increases these levels. However, the effect of statin therapy on coenzyme Q10 levels in muscle has been conflicting. Recently, two pilot studies on coenzyme Q10 supplementation in statin-induced myopathy and one study on the effect of coenzyme Q10 supplementation on serum muscle enzyme levels were published. These three studies were the first randomized trials with coenzyme Q10 supplementation in hypercholesterolemic patients treated with statins. The results of these trials have been contradictory; whereas one seems to support supplementation with coenzyme Q10, the other two do not.

SUMMARY

This review summarizes the current evidence on coenzyme Q10 supplementation in statin-induced myopathy. We conclude that the present evidence does not support coenzyme Q10 supplementation in statin-induced myopathy.

Authors+Show Affiliations

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18957876

Citation

Schaars, Carel F., and Anton F H. Stalenhoef. "Effects of Ubiquinone (coenzyme Q10) On Myopathy in Statin Users." Current Opinion in Lipidology, vol. 19, no. 6, 2008, pp. 553-7.
Schaars CF, Stalenhoef AF. Effects of ubiquinone (coenzyme Q10) on myopathy in statin users. Curr Opin Lipidol. 2008;19(6):553-7.
Schaars, C. F., & Stalenhoef, A. F. (2008). Effects of ubiquinone (coenzyme Q10) on myopathy in statin users. Current Opinion in Lipidology, 19(6), 553-7. https://doi.org/10.1097/MOL.0b013e3283168ecd
Schaars CF, Stalenhoef AF. Effects of Ubiquinone (coenzyme Q10) On Myopathy in Statin Users. Curr Opin Lipidol. 2008;19(6):553-7. PubMed PMID: 18957876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of ubiquinone (coenzyme Q10) on myopathy in statin users. AU - Schaars,Carel F, AU - Stalenhoef,Anton F H, PY - 2008/10/30/pubmed PY - 2009/3/7/medline PY - 2008/10/30/entrez SP - 553 EP - 7 JF - Current opinion in lipidology JO - Curr. Opin. Lipidol. VL - 19 IS - 6 N2 - PURPOSE OF REVIEW: Statins are associated with muscle complaints, including myositis. The mechanism through which statin use causes muscle toxicity is unknown. One of the theories is that statin therapy reduces coenzyme Q10 levels in muscle mitochondria, which leads to muscle injury and myopathy. The aim of the present article is to review published data on the association between coenzyme Q10 and statin-associated myopathy. RECENT FINDINGS: Studies have consistently shown that statins reduce coenzyme Q10 levels in serum and that supplementation of coenzyme Q10 increases these levels. However, the effect of statin therapy on coenzyme Q10 levels in muscle has been conflicting. Recently, two pilot studies on coenzyme Q10 supplementation in statin-induced myopathy and one study on the effect of coenzyme Q10 supplementation on serum muscle enzyme levels were published. These three studies were the first randomized trials with coenzyme Q10 supplementation in hypercholesterolemic patients treated with statins. The results of these trials have been contradictory; whereas one seems to support supplementation with coenzyme Q10, the other two do not. SUMMARY: This review summarizes the current evidence on coenzyme Q10 supplementation in statin-induced myopathy. We conclude that the present evidence does not support coenzyme Q10 supplementation in statin-induced myopathy. SN - 0957-9672 UR - https://www.unboundmedicine.com/medline/citation/18957876/Effects_of_ubiquinone__coenzyme_Q10__on_myopathy_in_statin_users_ L2 - http://dx.doi.org/10.1097/MOL.0b013e3283168ecd DB - PRIME DP - Unbound Medicine ER -