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Is there a role for mesenchymal stem cells in autoimmune diseases?
Autoimmunity. 2008 Dec; 41(8):592-5.A

Abstract

Recent reports have highlighted that adult stem cells are granted with yet poorly understood properties other than multipotentiality. In particular, mesenchymal stem cells (MSCs) represent a subset of adult stromal cells that can down-regulate several functions of the immune cells. In addition, MSCs may promote survival of damaged cells and tissues through paracrine mechanisms, possibly under the guidance of environmental cues. Thus, MSCs clinical application in autoimmune diseases seems an appealing opportunity and preclinical results in different experimental models of autoimmunity further support this strategy. Despite the absolute need for caution related to several clinical and technical issues, MSCs are now on the edge of a new era of clinical applications.

Authors+Show Affiliations

Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy. auccelli@neurologia.unige.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18958745

Citation

Uccelli, Antonio, et al. "Is There a Role for Mesenchymal Stem Cells in Autoimmune Diseases?" Autoimmunity, vol. 41, no. 8, 2008, pp. 592-5.
Uccelli A, Mancardi G, Chiesa S. Is there a role for mesenchymal stem cells in autoimmune diseases? Autoimmunity. 2008;41(8):592-5.
Uccelli, A., Mancardi, G., & Chiesa, S. (2008). Is there a role for mesenchymal stem cells in autoimmune diseases? Autoimmunity, 41(8), 592-5. https://doi.org/10.1080/08916930802200166
Uccelli A, Mancardi G, Chiesa S. Is There a Role for Mesenchymal Stem Cells in Autoimmune Diseases. Autoimmunity. 2008;41(8):592-5. PubMed PMID: 18958745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there a role for mesenchymal stem cells in autoimmune diseases? AU - Uccelli,Antonio, AU - Mancardi,Gianluigi, AU - Chiesa,Sabrina, PY - 2008/10/30/pubmed PY - 2010/3/5/medline PY - 2008/10/30/entrez SP - 592 EP - 5 JF - Autoimmunity JO - Autoimmunity VL - 41 IS - 8 N2 - Recent reports have highlighted that adult stem cells are granted with yet poorly understood properties other than multipotentiality. In particular, mesenchymal stem cells (MSCs) represent a subset of adult stromal cells that can down-regulate several functions of the immune cells. In addition, MSCs may promote survival of damaged cells and tissues through paracrine mechanisms, possibly under the guidance of environmental cues. Thus, MSCs clinical application in autoimmune diseases seems an appealing opportunity and preclinical results in different experimental models of autoimmunity further support this strategy. Despite the absolute need for caution related to several clinical and technical issues, MSCs are now on the edge of a new era of clinical applications. SN - 1607-842X UR - https://www.unboundmedicine.com/medline/citation/18958745/Is_there_a_role_for_mesenchymal_stem_cells_in_autoimmune_diseases L2 - http://www.tandfonline.com/doi/full/10.1080/08916930802200166 DB - PRIME DP - Unbound Medicine ER -