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A relationship between increased peritoneal leptin levels and infertility in endometriosis.
Gynecol Endocrinol 2008; 24(9):526-30GE

Abstract

Endometriosis is a common, complex and chronic disease related to ectopic implantation and growth of endometrial tissue that may manifest by pelvic pain, and accounts for over 20% of all cases of infertility in women. Endometriosis may be associated with increased levels of leptin in peritoneal fluid. However, the association of leptin with infertility has not been definitely documented. Therefore, the aim of the present study was to search for a relationship between concentrations of peritoneal-fluid leptin and patients' clinical status. The study included 56 patients being diagnosed for infertility and/or pelvic pain. Peritoneal fluid was aspirated during routine laparoscopic examination. Concentrations of leptin in peritoneal fluid were evaluated by a specific enzyme-linked immunosorbent assay. The results revealed that the levels of peritoneal-fluid leptin did not correlate with different stage of endometriosis. However, they correlated with body mass index. Leptin levels were significantly higher in infertile patients than in patients with pelvic pain (p = 0.0023 by Mann-Whitney U test or p = 0.0045 by analysis of variance). It may suggest that increased leptin levels in the peritoneal fluid may play a role in pathogenesis of infertility.

Authors+Show Affiliations

I Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18958774

Citation

Barcz, Ewa, et al. "A Relationship Between Increased Peritoneal Leptin Levels and Infertility in Endometriosis." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 24, no. 9, 2008, pp. 526-30.
Barcz E, Milewski L, Radomski D, et al. A relationship between increased peritoneal leptin levels and infertility in endometriosis. Gynecol Endocrinol. 2008;24(9):526-30.
Barcz, E., Milewski, L., Radomski, D., Dziunycz, P., Kamiński, P., Roszkowski, P. I., & Malejczyk, J. (2008). A relationship between increased peritoneal leptin levels and infertility in endometriosis. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 24(9), pp. 526-30. doi:10.1080/09513590802288200.
Barcz E, et al. A Relationship Between Increased Peritoneal Leptin Levels and Infertility in Endometriosis. Gynecol Endocrinol. 2008;24(9):526-30. PubMed PMID: 18958774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A relationship between increased peritoneal leptin levels and infertility in endometriosis. AU - Barcz,Ewa, AU - Milewski,Lukasz, AU - Radomski,Dariusz, AU - Dziunycz,Piotr, AU - Kamiński,Paweł, AU - Roszkowski,Piotr I, AU - Malejczyk,Jacek, PY - 2008/10/30/pubmed PY - 2009/1/29/medline PY - 2008/10/30/entrez SP - 526 EP - 30 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 24 IS - 9 N2 - Endometriosis is a common, complex and chronic disease related to ectopic implantation and growth of endometrial tissue that may manifest by pelvic pain, and accounts for over 20% of all cases of infertility in women. Endometriosis may be associated with increased levels of leptin in peritoneal fluid. However, the association of leptin with infertility has not been definitely documented. Therefore, the aim of the present study was to search for a relationship between concentrations of peritoneal-fluid leptin and patients' clinical status. The study included 56 patients being diagnosed for infertility and/or pelvic pain. Peritoneal fluid was aspirated during routine laparoscopic examination. Concentrations of leptin in peritoneal fluid were evaluated by a specific enzyme-linked immunosorbent assay. The results revealed that the levels of peritoneal-fluid leptin did not correlate with different stage of endometriosis. However, they correlated with body mass index. Leptin levels were significantly higher in infertile patients than in patients with pelvic pain (p = 0.0023 by Mann-Whitney U test or p = 0.0045 by analysis of variance). It may suggest that increased leptin levels in the peritoneal fluid may play a role in pathogenesis of infertility. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/18958774/A_relationship_between_increased_peritoneal_leptin_levels_and_infertility_in_endometriosis_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590802288200 DB - PRIME DP - Unbound Medicine ER -