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Inhibitory effects of licochalcone A isolated from Glycyrrhiza inflata root on inflammatory ear edema and tumour promotion in mice.
Planta Med. 1991 Jun; 57(3):221-4.PM

Abstract

Licochalcone A, 3-a,a-dimethylallyl-4,4'-dihydroxy-6-methoxychalcone, from the root of Glycyrrhiza inflata Beta (Leguminosae) (Xin-jiang liquorice) showed anti-inflammatory action towards mouse ear edema induced by arachidonic acid (AA) and 12-O-tetradecanoylphorbol 13-acetate (TPA) by topical application. Anti-tumour promoting action of licochalcone A was also observed in vivo for mouse skin papilloma initiated by dimethylbenz[a]anthracene (DMBA) and promoted by TPA. It inhibited in vitro 32Pi-incorporation to phospholipids in HeLa cells promoted by TPA. A competitive interaction of licochalcone A with the TPA-receptors in the cell membrane has been suggested.

Authors+Show Affiliations

Shibata Laboratory of Natural Medicinal Materials, Minophagen Pharmaceutical Co., Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1896519

Citation

Shibata, S, et al. "Inhibitory Effects of Licochalcone a Isolated From Glycyrrhiza Inflata Root On Inflammatory Ear Edema and Tumour Promotion in Mice." Planta Medica, vol. 57, no. 3, 1991, pp. 221-4.
Shibata S, Inoue H, Iwata S, et al. Inhibitory effects of licochalcone A isolated from Glycyrrhiza inflata root on inflammatory ear edema and tumour promotion in mice. Planta Med. 1991;57(3):221-4.
Shibata, S., Inoue, H., Iwata, S., Ma, R. D., Yu, L. J., Ueyama, H., Takayasu, J., Hasegawa, T., Tokuda, H., & Nishino, A. (1991). Inhibitory effects of licochalcone A isolated from Glycyrrhiza inflata root on inflammatory ear edema and tumour promotion in mice. Planta Medica, 57(3), 221-4.
Shibata S, et al. Inhibitory Effects of Licochalcone a Isolated From Glycyrrhiza Inflata Root On Inflammatory Ear Edema and Tumour Promotion in Mice. Planta Med. 1991;57(3):221-4. PubMed PMID: 1896519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effects of licochalcone A isolated from Glycyrrhiza inflata root on inflammatory ear edema and tumour promotion in mice. A1 - Shibata,S, AU - Inoue,H, AU - Iwata,S, AU - Ma,R D, AU - Yu,L J, AU - Ueyama,H, AU - Takayasu,J, AU - Hasegawa,T, AU - Tokuda,H, AU - Nishino,A, PY - 1991/6/1/pubmed PY - 1991/6/1/medline PY - 1991/6/1/entrez SP - 221 EP - 4 JF - Planta medica JO - Planta Med. VL - 57 IS - 3 N2 - Licochalcone A, 3-a,a-dimethylallyl-4,4'-dihydroxy-6-methoxychalcone, from the root of Glycyrrhiza inflata Beta (Leguminosae) (Xin-jiang liquorice) showed anti-inflammatory action towards mouse ear edema induced by arachidonic acid (AA) and 12-O-tetradecanoylphorbol 13-acetate (TPA) by topical application. Anti-tumour promoting action of licochalcone A was also observed in vivo for mouse skin papilloma initiated by dimethylbenz[a]anthracene (DMBA) and promoted by TPA. It inhibited in vitro 32Pi-incorporation to phospholipids in HeLa cells promoted by TPA. A competitive interaction of licochalcone A with the TPA-receptors in the cell membrane has been suggested. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/1896519/Inhibitory_effects_of_licochalcone_A_isolated_from_Glycyrrhiza_inflata_root_on_inflammatory_ear_edema_and_tumour_promotion_in_mice_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-960078 DB - PRIME DP - Unbound Medicine ER -