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Anti-tumor-promotion by principles obtained from Angelica keiskei.
Planta Med. 1991 Jun; 57(3):242-6.PM

Abstract

Potent anti-tumor promoter activity has been found in the nonpolar extracts of the root of "Ashita-Ba", Angelica keiskei Koidz. (Umbelliferae), which is eaten as a vegetable in Japan. From this active fraction, two angular furanocoumarins, archangelicin (1) and 8(S),9(R)-9-angeloyloxy-8,9-dihydrooroselol (2), three linear furanocoumarins, psoralen (3), bergapten (4) and xanthotoxin (5), and three chalcones, 4-hydroxyderricin (6), xanthoangelol (7) and a novel chalcone named ashitaba-chalcone (8), were isolated. Among these compounds, two angular type furanocoumarins, 1 and 2, and three chalcones, 6-8, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of cultured cells, whereas coumarins 3-5 were less effective. In addition, chalcones 6 and 7 were proved to have anti-tumor-promoting activity in mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) plus TPA. Since chalcones 6 and 7 showed calmodulin-interacting property, both chalcones may reveal anti-tumor-promoting activity via the modulation of calmodulin involved systems. These chalcones may be useful to develop the effective method for cancer prevention.

Authors+Show Affiliations

Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1896522

Citation

Okuyama, T, et al. "Anti-tumor-promotion By Principles Obtained From Angelica Keiskei." Planta Medica, vol. 57, no. 3, 1991, pp. 242-6.
Okuyama T, Takata M, Takayasu J, et al. Anti-tumor-promotion by principles obtained from Angelica keiskei. Planta Med. 1991;57(3):242-6.
Okuyama, T., Takata, M., Takayasu, J., Hasegawa, T., Tokuda, H., Nishino, A., Nishino, H., & Iwashima, A. (1991). Anti-tumor-promotion by principles obtained from Angelica keiskei. Planta Medica, 57(3), 242-6.
Okuyama T, et al. Anti-tumor-promotion By Principles Obtained From Angelica Keiskei. Planta Med. 1991;57(3):242-6. PubMed PMID: 1896522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-tumor-promotion by principles obtained from Angelica keiskei. AU - Okuyama,T, AU - Takata,M, AU - Takayasu,J, AU - Hasegawa,T, AU - Tokuda,H, AU - Nishino,A, AU - Nishino,H, AU - Iwashima,A, PY - 1991/6/1/pubmed PY - 1991/6/1/medline PY - 1991/6/1/entrez SP - 242 EP - 6 JF - Planta medica JO - Planta Med. VL - 57 IS - 3 N2 - Potent anti-tumor promoter activity has been found in the nonpolar extracts of the root of "Ashita-Ba", Angelica keiskei Koidz. (Umbelliferae), which is eaten as a vegetable in Japan. From this active fraction, two angular furanocoumarins, archangelicin (1) and 8(S),9(R)-9-angeloyloxy-8,9-dihydrooroselol (2), three linear furanocoumarins, psoralen (3), bergapten (4) and xanthotoxin (5), and three chalcones, 4-hydroxyderricin (6), xanthoangelol (7) and a novel chalcone named ashitaba-chalcone (8), were isolated. Among these compounds, two angular type furanocoumarins, 1 and 2, and three chalcones, 6-8, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of cultured cells, whereas coumarins 3-5 were less effective. In addition, chalcones 6 and 7 were proved to have anti-tumor-promoting activity in mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) plus TPA. Since chalcones 6 and 7 showed calmodulin-interacting property, both chalcones may reveal anti-tumor-promoting activity via the modulation of calmodulin involved systems. These chalcones may be useful to develop the effective method for cancer prevention. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/1896522/Anti_tumor_promotion_by_principles_obtained_from_Angelica_keiskei_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-960082 DB - PRIME DP - Unbound Medicine ER -